Protein Alignment aPKC and Akt1

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_150233.1
• Gene: Akt1 / 24185
• RGDID: 2081
• Length: 480
• Species: Rattus norvegicus
• Alignment Length: 510
• Identity: 184/510 - (36%)
• Similarity: 275/510 - (53%)
• Gaps: 91/510 - (17%)

  Fly   481 IYRRG--ARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ-----GFKCIQCKLLVHKK 538
            :::||  .:.||..|      |..|  |...|..| ::|...:.::     .|...||:|:.
  Rat    12 LHKRGEYIKTWRPRY------FLLK--NDGTFIGY-KERPQDVEQRESPLNNFSVAQCQLMK--- 64

  Fly   539 CHKLVQKHCTDQPEP---LVK-----------------ERAEESSDPIPVPLPPL---PYEAM-- 578
                     |::|.|   :::                 |..||.:..|......|   ..|.|
  Rat    65 ---------TERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDF 120

  Fly   579 -------SGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELR 636
                   :.|||..|       ||...|        :.:.::|:||.::::|:|::.||::|:.:
  Rat   121 RSGSPSDNSGAEEME-------VALAKP--------KHRVTMNEFEYLKLLGKGTFGKVILVKEK 170

  Fly   637 RTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGD 701
            .|.|.||||::||.::...:::....||..|.:. |.||||..|...|||..||.||:|:..||:
  Rat   171 ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGE 234

  Fly   702 LMYHMQRQRRLPEEHARFYAAEISLALNFLH-EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            |.:|:.|:|...|:.||||.|||..||::|| ||.::||||||:|::||.:||||:||:|:||||
  Rat   235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
            |:.|.|..||||||.|:|||:|...|||.:||||.|||::|||:.||.||      .|.|   .:
  Rat   300 IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HE 355

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
            .||::||.:.||.||:|...|.|:|.|.|.|:|..|||...|.| .:|:.|.||.|:.|:.:..|
  Rat   356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDA-KEIMQHRFFANIVWQDVYEK 419

  Fly   896 QVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDD----HVIDNIDQSEFEGFEY 946
            :::|||||::.|:.|...|..|||.:.:.:||.|.    ..:|:..:..|..|.|
  Rat   420 KLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	11/58 (19%)
		STKc_aPKC	620..947	CDD:270740	149/332 (45%)
Akt1	NP_150233.1	PH_PKB	4..111	CDD:269947	22/119 (18%)
		STKc_PKB_alpha	124..479	CDD:270746	159/377 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	451..480		6/24 (25%)