DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and Akt1

DIOPT Version :9

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_150233.1 Gene:Akt1 / 24185 RGDID:2081 Length:480 Species:Rattus norvegicus


Alignment Length:510 Identity:184/510 - (36%)
Similarity:275/510 - (53%) Gaps:91/510 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 IYRRG--ARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQ-----GFKCIQCKLLVHKK 538
            :::||  .:.||..|      |..|  |...|..| ::|...:.::     .|...||:|:.   
  Rat    12 LHKRGEYIKTWRPRY------FLLK--NDGTFIGY-KERPQDVEQRESPLNNFSVAQCQLMK--- 64

  Fly   539 CHKLVQKHCTDQPEP---LVK-----------------ERAEESSDPIPVPLPPL---PYEAM-- 578
                     |::|.|   :::                 |..||.:..|......|   ..|.|  
  Rat    65 ---------TERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKRQEEETMDF 120

  Fly   579 -------SGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELR 636
                   :.|||..|       ||...|        :.:.::|:||.::::|:|::.||::|:.:
  Rat   121 RSGSPSDNSGAEEME-------VALAKP--------KHRVTMNEFEYLKLLGKGTFGKVILVKEK 170

  Fly   637 RTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGD 701
            .|.|.||||::||.::...:::....||..|.:. |.||||..|...|||..||.||:|:..||:
  Rat   171 ATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQN-SRHPFLTALKYSFQTHDRLCFVMEYANGGE 234

  Fly   702 LMYHMQRQRRLPEEHARFYAAEISLALNFLH-EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            |.:|:.|:|...|:.||||.|||..||::|| ||.::||||||:|::||.:||||:||:|:||||
  Rat   235 LFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEG 299

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
            |:.|.|..||||||.|:|||:|...|||.:||||.|||::|||:.||.||      .|.|   .:
  Rat   300 IKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HE 355

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
            .||::||.:.||.||:|...|.|:|.|.|.|:|..|||...|.| .:|:.|.||.|:.|:.:..|
  Rat   356 KLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDA-KEIMQHRFFANIVWQDVYEK 419

  Fly   896 QVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDD----HVIDNIDQSEFEGFEY 946
            :::|||||::.|:.|...|..|||.:.:.:||.|.    ..:|:..:..|..|.|
  Rat   420 KLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSY 474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_1 498..550 CDD:278556 11/56 (20%)
S_TKc 616..884 CDD:214567 128/268 (48%)
STKc_aPKC 620..947 CDD:270740 149/332 (45%)
Akt1NP_150233.1 PH_PKB 4..111 CDD:269947 22/119 (18%)
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 14..19 2/4 (50%)
Inositol-(1,3,4,5)-tetrakisphosphate binding. /evidence=ECO:0000250 23..25 1/1 (100%)
STKc_PKB_alpha 124..479 CDD:270746 159/377 (42%)
Inhibitor binding. /evidence=ECO:0000250 228..230 1/1 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 451..480 6/24 (25%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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