Protein Alignment aPKC and SGK3

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_037389.4
• Gene: SGK3 / 23678
• HGNCID: 10812
• Length: 496
• Species: Homo sapiens
• Alignment Length: 515
• Identity: 175/515 - (33%)
• Similarity: 275/515 - (53%)
• Gaps: 73/515 - (14%)

  Fly   470 PGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLL 534
            |.:|....|.  :|...:|: .:|:|...:.:::.|..|.:..:  |:::...::.|..:..|:
Human    14 PSVSIPSSDE--HREKKKRF-TVYKVLVSVGRSEWFVFRRYAEF--DKLYNTLKKQFPAMALKI- 72

  Fly   535 VHKKCHKLVQKHCTDQPEP-LVKERAEESSDPIP--VPLPPLPYEAMSGGAEACETHDHAHIVA- 595
                   ..::...|..:| .:|:|....::.|.  |..|              |.::|..:.|
Human    73 -------PAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYP--------------ELYNHPDVRAF 116

  Fly   596 ---------PPPPEDPLEPGTQRQYSLN----------------DFELIRVIGRGSYAKVLMVEL 635
                     ..|.||..|..:|:.:|.:                ||:.::|||:||:.|||:.:.
Human   117 LQMDSPKHQSDPSEDEDERSSQKLHSTSQNINLGPSGNPHAKPTDFDFLKVIGKGSFGKVLLAKR 181

  Fly   636 RRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGG 700
            :...:.||:||::|.:|.:.::...:..|::|......||||||||..|||..:|:||::||.||
Human   182 KLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246

  Fly   701 DLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            :|.:|:||:|..||..||||||||:.||.:||...|:|||||.:|:|||..||:.|||:|:||||
Human   247 ELFFHLQRERSFPEHRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSVGHVVLTDFGLCKEG 311

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
            |...|||:||||||.|:|||::|.:.|..:||||.||.:|||||.|..||.....:|
Human   312 IAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE-------- 368

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
             ::..||.|.:.:...:|:.|.|:|:..|.|:..:|||...:  |::|.:||||:::.|..|.:|
Human   369 -MYDNILHKPLSLRPGVSLTAWSILEELLEKDRQNRLGAKED--FLEIQNHPFFESLSWADLVQK 430

  Fly   896 QVTPPFKPRLDSDRDLANFPPEFTGEAV--QLTPDDDHVIDNIDQSE----FEGFEYVNP 949
            ::.|||.|.:....|:.||...||.|.|  .:....|:.|.|....|    |.||.|..|
Human   431 KIPPPFNPNVAGPDDIRNFDTAFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	5/53 (9%)
		STKc_aPKC	620..947	CDD:270740	143/332 (43%)
SGK3	NP_037389.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21		2/6 (33%)
		PX_CISK	12..120	CDD:132780	22/132 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..156		6/34 (18%)
		STKc_SGK3	165..490	CDD:270755	144/335 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		2/9 (22%)