Protein Alignment aPKC and Aurkb

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_035626.1
• Gene: Aurkb / 20877
• MGIID: 107168
• Length: 345
• Species: Mus musculus
• Alignment Length: 302
• Identity: 80/302 - (26%)
• Similarity: 155/302 - (51%)
• Gaps: 36/302 - (11%)

  Fly   606 GTQRQ--YSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDW-----VQT 663
            |:|.:  :::::||:.|.:|:|.:..|.:...:::|.|.|:|::.|:.: :.|.::.     ::.
Mouse    70 GSQNKQPFTIDNFEIGRPLGKGKFGNVYLAREKKSRFIVALKILFKSQI-EKEGVEHQLRREIEI 133

  Fly   664 EKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLAL 728
            :.|:     .||.::.|::.|....|::.::|:...|:|...:|:.|...|:.......|:|.||
Mouse   134 QAHL-----KHPNILQLYNYFYDQQRIYLILEYAPRGELYKELQKSRTFDEQRTATIMEELSDAL 193

  Fly   729 NFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYG 793
            .:.|:|.:|:||:|.:|:||..:|.:|:.|:|.....  |.....|.|||.:|:.||::.|..:.
Mouse   194 TYCHKKKVIHRDIKPENLLLGLQGELKIADFGWSVHA--PSLRRKTMCGTLDYLPPEMIEGRMHN 256

  Fly   794 FSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGF 858
            ..||.|.:|||.||::.|..||:....||.         ::.|::..::.|.|:...|..::...
Mouse   257 EMVDLWCIGVLCYELMVGNPPFESPSHSET---------YRRIVKVDLKFPSSVPSGAQDLISKL 312

  Fly   859 LNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPP 900
            |..||..||      ...::.:||      |.....::|.||
Mouse   313 LKHNPWQRL------PLAEVAAHP------WVRANSRRVLPP 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344
		STKc_aPKC	620..947	CDD:270740	76/286 (27%)
Aurkb	NP_035626.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	50..77		2/6 (33%)
		Protein Kinases, catalytic domain	77..344	CDD:473864	78/295 (26%)