Protein Alignment aPKC and AKT2

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001617.1
• Gene: AKT2 / 208
• HGNCID: 392
• Length: 481
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 162/443 - (36%)
• Similarity: 251/443 - (56%)
• Gaps: 66/443 - (14%)

  Fly   527 KCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHA 591
            :|:|...::.:..|       .|.|:    || ||....|.:....|...|
Human    76 RCLQWTTVIERTFH-------VDSPD----ER-EEWMRAIQMVANSLKQRA-------------- 114

  Fly   592 HIVAPPPPEDPLE-----PG--------------TQRQYSLNDFELIRVIGRGSYAKVLMVELRR 637
                  |.|||::     |.              .:.:.::|||:.::::|:|::.||::|..:.
Human   115 ------PGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKA 173

  Fly   638 TRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDL 702
            |.|.||||:::|.::...:::....||..|.:. :.||||..|...|||..||.||:|:..||:|
Human   174 TGRYYAMKILRKEVIIAKDEVAHTVTESRVLQN-TRHPFLTALKYAFQTHDRLCFVMEYANGGEL 237

  Fly   703 MYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIR 767
            .:|:.|:|...||.||||.|||..||.:||.:.::|||:||:|::||.:||||:||:|:|||||.
Human   238 FFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGIS 302

  Fly   768 PGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYL 832
            .|.|..||||||.|:|||:|...|||.:||||.|||::|||:.||.||      .|.|   .:.|
Human   303 DGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HERL 358

  Fly   833 FQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQV 897
            |::||.:.||.||:||..|.|:|.|.|.|:|..|||.....| .:::.|.||.:::|:.:.:|::
Human   359 FELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDA-KEVMEHRFFLSINWQDVVQKKL 422

  Fly   898 TPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDH----VIDNIDQSEFEGFEY 946
            .|||||::.|:.|...|..|||.:::.:||.|.:    :::...::.|..|.|
Human   423 LPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSY 475

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	3/22 (14%)
		STKc_aPKC	620..947	CDD:270740	142/331 (43%)
AKT2	NP_001617.1	PH_PKB	4..111	CDD:269947	10/46 (22%)
		STKc_PKB_beta	156..478	CDD:173686	142/331 (43%)