DRSC/TRiP Functional Genomics Resources

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Protein Alignment aPKC and Prkci

DIOPT Version :10

Sequence 1:NP_001260984.1 Gene:aPKC / 47594 FlyBaseID:FBgn0261854 Length:958 Species:Drosophila melanogaster
Sequence 2:NP_032883.2 Gene:Prkci / 18759 MGIID:99260 Length:595 Species:Mus musculus


Alignment Length:633 Identity:373/633 - (58%)
Similarity:435/633 - (68%) Gaps:110/633 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   383 CGGGSIAGGSIGGRSSVLGTIHNGHGHHHQ----QYHHECI---HYERLPIPVPIPTVPM-GVAP 439
            ||||.                    .|.||    .|:...|   |:|        |::.. |:..
Mouse    16 CGGGG--------------------DHSHQVRVKAYYRGDIMITHFE--------PSISFEGLCS 52

  Fly   440 SSQQMSQHQ------------------LQSEEEIEPAYAT------------VFPNVPQAPGLSC 474
            ..:.|....                  :.|:.|:|.|:..            |||.||:.||:.|
Mouse    53 EVRDMCSFDNEQPFTMKWIDEEGDPCTVSSQLELEEAFRLYELNKDSELLIHVFPCVPERPGMPC 117

  Fly   475 DGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKC 539
            .|||:||||||||||||||..|||.||||||||||.||.|.||||||||||:|||.|||||||||
Mouse   118 PGEDKSIYRRGARRWRKLYCANGHTFQAKRFNRRAHCAICTDRIWGLGRQGYKCINCKLLVHKKC 182

  Fly   540 HKLVQKHC---TDQPEPLVKERAEESSDPIPVPLPPLPYEAMSGGAEACETHDHAHIVAP--PPP 599
            ||||...|   :..|||::         |:...:.|                ||...|.|  |..
Mouse   183 HKLVTIECGRHSLPPEPMM---------PMDQTMHP----------------DHTQTVIPYNPSS 222

  Fly   600 EDPLEPGTQRQYSLN--------------DFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKA 650
            .:.|:...:.:.::|              ||:|:||||||||||||:|.|::|.|||||||:||.
Mouse   223 HESLDQVGEEKEAMNTRESGKASSSLGLQDFDLLRVIGRGSYAKVLLVRLKKTDRIYAMKVVKKE 287

  Fly   651 LVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEE 715
            ||.||||||||||||||||.||||||||||||||||.||||||||:|.|||||:||||||:||||
Mouse   288 LVNDDEDIDWVQTEKHVFEQASNHPFLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEE 352

  Fly   716 HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPN 780
            |||||:||||||||:|||:|||||||||||||||.|||||||||||||||:||||||||||||||
Mouse   353 HARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPN 417

  Fly   781 YIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPR 845
            ||||||||||||||||||||||||::||:|||||||:.|:|:|||||||||||||||||.|||||
Mouse   418 YIAPEILRGEDYGFSVDWWALGVLMFEMMAGRSPFDIVGSSDNPDQNTEDYLFQVILEKQIRIPR 482

  Fly   846 SLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRD 910
            ||||:||||||.||||:|.:|||||.::.|.||..||||:|:||:::|:|||.|||||.:..:..
Mouse   483 SLSVKAASVLKSFLNKDPKERLGCHPQTGFADIQGHPFFRNVDWDMMEQKQVVPPFKPNISGEFG 547

  Fly   911 LANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLEDCV 958
            |.||..:||.|.||||||||.::..|||||||||||:||||||.|:||
Mouse   548 LDNFDSQFTNEPVQLTPDDDDIVRKIDQSEFEGFEYINPLLMSAEECV 595

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
aPKCNP_001260984.1 C1_aPKC 496..550 CDD:410344 43/56 (77%)
STKc_aPKC 620..947 CDD:270740 262/326 (80%)
PrkciNP_032883.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21 4/24 (17%)
Regulatory domain. /evidence=ECO:0000250 2..252 98/288 (34%)
Required for interaction with RAB2. /evidence=ECO:0000250 2..28 7/31 (23%)
PB1_aPKC 26..108 CDD:99725 13/89 (15%)
Interaction with PARD6A. /evidence=ECO:0000250 72..91 4/18 (22%)
Pseudosubstrate 125..134 8/8 (100%)
C1_aPKC 139..193 CDD:410344 43/53 (81%)
STKc_aPKC_iota 232..595 CDD:270769 274/362 (76%)

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