Protein Alignment aPKC and Prkcd

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001297611.1
• Gene: Prkcd / 18753
• MGIID: 97598
• Length: 700
• Species: Mus musculus
• Alignment Length: 641
• Identity: 218/641 - (34%)
• Similarity: 313/641 - (48%)
• Gaps: 148/641 - (23%)

  Fly   429 PIPTVPMGVAPSSQQMSQHQLQSEEEIEPAYATVFPNVPQAPGLSC------DGEDR-------- 479
            |:..|.:||:..:::..::..::|..::..        |||..|.|      ||:.:
Mouse    80 PVSEVTVGVSVLAERCKKNNGKAEFWLDLQ--------PQAKVLMCVQYFLEDGDCKQSMRSEEE 136

  Fly   480 ----SIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCH 540
                ::.||||.:..|::.:..|.|.|..|.:..||:.|::.:|||.:||:||.||...:||||.
Mouse   137 AKFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCI 201

  Fly   541 KLVQKHCT------------------DQPE---------------------PLVKE--------- 557
            ..:...||                  |.|.                     .|||:
Mouse   202 DKIIGRCTGTATNSRDTIFQKERFNIDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKCEDCGM 266

  Fly   558 ---------------------------------RAEESSDPIPVPLPPLPYEA------MSGGAE 583
                                             |..::::.:.:      |:.      :||...
Mouse   267 NVHHKCREKVANLCGINQKLLAEALNQVTQRSSRKLDTTESVGI------YQGFEKKPEVSGSDI 325

  Fly   584 ACETHDHAHIVAPPP----PEDPLEP----GT-------QRQYSLNDFELIRVIGRGSYAKVLMV 633
            ..|...|..:....|    .:|..|.    ||       ..:.:|.:|...:|:|:||:.|||:.
Mouse   326 LGEAGSHISLKLSFPSRAKEKDSSETCDNNGTYGKIWEGSTRCTLENFTFQKVLGKGSFGKVLLA 390

  Fly   634 ELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVR 698
            ||:...:.:|:|.:||.:|..|:|::....||.|...|...|||..|...|||...||||:||:.
Mouse   391 ELKGKDKYFAIKCLKKDVVLIDDDVECTMVEKRVLALAWESPFLTHLICTFQTKDHLFFVMEFLN 455

  Fly   699 GGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCK 763
            |||||:|:|.:.|.....|.||||||...|.|||.|||||||||||||:||.:||||:.|:||||
Mouse   456 GGDLMFHIQDKGRFELYRATFYAAEIICGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCK 520

  Fly   764 EGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNT 828
            |.|......|||||||:|||||||:|..|.||||||:.||||||||.|:|||         ..:.
Mouse   521 ENIFGEGRASTFCGTPDYIAPEILQGLKYSFSVDWWSFGVLLYEMLIGQSPF---------HGDD 576

  Fly   829 EDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLE 893
            ||.||:.|...|...||.::..:..:::....::|..|||     ...:|..|||||.::|.|||
Mouse   577 EDELFESIRVDTPHYPRWITKESKDIMEKLFERDPDKRLG-----VTGNIRIHPFFKTINWSLLE 636

  Fly   894 RKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949
            :::|.|||||::.|..|.:||.|||..|..||:..|.::||::||..|.||.:|||
Mouse   637 KRKVEPPFKPKVKSPSDYSNFDPEFLNEKPQLSFSDKNLIDSMDQEAFHGFSFVNP 692

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	22/69 (32%)
		S_TKc	616..884	CDD:214567	128/267 (48%)
		STKc_aPKC	620..947	CDD:270740	158/326 (48%)
Prkcd	NP_001297611.1	C1_1	159..208	CDD:365894	20/48 (42%)
		C1_1	231..281	CDD:365894	3/49 (6%)
		PKc_like	377..692	CDD:389743	159/328 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920