Protein Alignment aPKC and Prkcg

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_035232.1
• Gene: Prkcg / 18752
• MGIID: 97597
• Length: 697
• Species: Mus musculus
• Alignment Length: 682
• Identity: 231/682 - (33%)
• Similarity: 314/682 - (46%)
• Gaps: 214/682 - (31%)

  Fly   471 GLSCDGEDRSIY-RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLL 534
            |...:|..|.:: |:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||:|:||.:|..|..:
Mouse     8 GGDSEGGPRPLFCRKGALRQKVVHEVKSHKFTARFFKQPTFCSHCTDFIWGIGKQGLQCQVCSFV 72

  Fly   535 VHKKCHKLVQKHC--------TDQPEPLVKERAEESSDP-------------------------- 565
            ||::||:.|...|        ||.|....|.|....|.|
Mouse    73 VHRRCHEFVTFECPGAGKGPQTDDPRNKHKFRLHSYSSPTFCDHCGSLLYGLVHQGMKCSCCEMN 137

  Fly   566 --------IP------------------------------------VPLPPL----PY------- 575
                    :|                                    :|:.|.    ||
Mouse   138 VHRRCVRSVPSLCGVDHTERRGRLQLEIRAPTSDEIHITVGEARNLIPMDPNGLSDPYVKLKLIP 202

  Fly   576 ------------------------------------------------------EAMSGGA---- 582
                                                                  .|||.|.
Mouse   203 DPRNLTKQKTKTVKATLNPVWNETFVFNLKPGDVERRLSVEVWDWDRTSRNDFMGAMSFGVSELL 267

  Fly   583 -----------------------------------EAC----ETHDHAHI---VAPPPPEDPLEP 605
                                               |||    |.::...:   .:|.|...|...
Mouse   268 KAPVDGWYKLLNQEEGEYYNVPVADADNCSLLQKFEACNYPLELYERVRMGPSSSPIPSPSPSPT 332

  Fly   606 GTQR--------QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQ 662
            .::|        :..::||..:.|:|:||:.||::.|.|.:..:||:|::||.::..|:|:|...
Mouse   333 DSKRCFFGASPGRLHISDFSFLMVLGKGSFGKVMLAERRGSDELYAIKILKKDVIVQDDDVDCTL 397

  Fly   663 TEKHVFETASNHP-----FLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAA 722
            .||.|.......|     ||..|||.||||.||:||:|:|.|||||||:|:..:..|.||.||||
Mouse   398 VEKRVLALGGRGPGGRPHFLTQLHSTFQTPDRLYFVMEYVTGGDLMYHIQQLGKFKEPHAAFYAA 462

  Fly   723 EISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEIL 787
            ||::.|.|||.:||||||||||||:||.|||||:||:|||||.:.||.||.||||||:||||||:
Mouse   463 EIAIGLFFLHNQGIIYRDLKLDNVMLDAEGHIKITDFGMCKENVFPGSTTRTFCGTPDYIAPEII 527

  Fly   788 RGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAA 852
            ..:.||.|||||:.||||||||||:.||         |...|:.|||.|:|:|:..|:|||..|.
Mouse   528 AYQPYGKSVDWWSFGVLLYEMLAGQPPF---------DGEDEEELFQAIMEQTVTYPKSLSREAV 583

  Fly   853 SVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPE 917
            ::.||||.|:|..|||...:.. ..|.:|.||:.:|||.|||.::.|||:|| ...|...||...
Mouse   584 AICKGFLTKHPGKRLGSGPDGE-PTIRAHGFFRWIDWERLERLEIAPPFRPR-PCGRSGENFDKF 646

  Fly   918 FTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949
            ||..|..|||.|..|:.:|||::|:||.||||
Mouse   647 FTRAAPALTPPDRLVLASIDQADFQGFTYVNP 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	23/59 (39%)
		S_TKc	616..884	CDD:214567	142/272 (52%)
		STKc_aPKC	620..947	CDD:270740	171/331 (52%)
Prkcg	NP_035232.1	C1_cPKC_rpt1	34..91	CDD:410383	22/56 (39%)
		C1_cPKC_rpt2	101..154	CDD:410386	5/52 (10%)
		C2_PKC_alpha_gamma	158..289	CDD:175992	8/130 (6%)
		STKc_cPKC	354..677	CDD:270739	172/333 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910