DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and akt-1

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001023646.1	Gene:	akt-1 / 179424	WormBaseID:	WBGene00000102	Length:	546	Species:	Caenorhabditis elegans

Alignment Length:	381	Identity:	158/381 - (41%)
Similarity:	231/381 - (60%)	Gaps:	25/381 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   579 SGGAEACETHDHAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYA 643
            ||..:.|.....|.:::   ..|..|...:.:.::.||:.::|:|:|::.||::.:.:||:::||
Worm   159 SGHGDNCSIDFRASMIS---IADTSEAAKRDKITMEDFDFLKVLGKGTFGKVILCKEKRTQKLYA 220

  Fly   644 MKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQR 708
            :|::||.::...|::....||..|.:.. .||||..|...|||..||.||:||..||||.||:.|
Worm   221 IKILKKDVIIAREEVAHTLTENRVLQRC-KHPFLTELKYSFQTNDRLCFVMEFAIGGDLYYHLNR 284

  Fly   709 QRRLPEE-----HARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRP 768
            :.::.:|     .||||.:||.|||.:||...|:||||||:|:|||.:||||:.|:|:|||.|..
Worm   285 EVQMNKEGFSEPRARFYGSEIVLALGYLHANSIVYRDLKLENLLLDKDGHIKIADFGLCKEEISF 349

  Fly   769 GDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLF 833
            ||.||||||||.|:|||:|...|||..||||.:||::|||:.||.||      .:.|.|.   ||
Worm   350 GDKTSTFCGTPEYLAPEVLDDHDYGRCVDWWGVGVVMYEMMCGRLPF------YSKDHNK---LF 405

  Fly   834 QVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVT 898
            ::|:...:|.|..||..|.::|.|.|.|:|..|||...|.| ::|....||:.:|||...||::.
Worm   406 ELIMAGDLRFPSKLSQEARTLLTGLLVKDPTQRLGGGPEDA-LEICRADFFRTVDWEATYRKEIE 469

  Fly   899 PPFKPRLDSDRDLANFPPEFTGEAVQLTPDD-DHVIDNID-----QSEFEGFEYVN 948
            ||:||.:.|:.|.:.|..|||.:.|||||.. ...:..:|     ||.|..|.:.|
Worm   470 PPYKPNVQSETDTSYFDNEFTSQPVQLTPPSRSGALATVDEQEEMQSNFTQFSFHN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556
		S_TKc	616..884	CDD:214567	123/272 (45%)
		STKc_aPKC	620..947	CDD:270740	149/337 (44%)
akt-1	NP_001023646.1	PH_PKB	14..121	CDD:269947
		PH	16..118	CDD:278594
		S_TKc	193..448	CDD:214567	122/265 (46%)
		STKc_PKB	197..525	CDD:270723	149/338 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910