Protein Alignment aPKC and tpa-1

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001379590.1
• Gene: tpa-1 / 176825
• WormBaseID: WBGene00006599
• Length: 704
• Species: Caenorhabditis elegans
• Alignment Length: 606
• Identity: 206/606 - (33%)
• Similarity: 292/606 - (48%)
• Gaps: 113/606 - (18%)

  Fly   439 PSSQQMSQ--HQLQSEEEIEPAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQ 501
            |:.:.::|  |...:.::..|....:.......||:.        .||||.:..:::.:.||.|.
 Worm   113 PNGRILAQTRHLKNAPDDDHPVEDIMTSRSNSGPGIQ--------RRRGAIKHARVHEIRGHQFV 169

  Fly   502 AKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPI 566
            |..|.:..||:.|.|.:|||.:||::|..|...||||||:.|...|....:...:..|.:....:
 Worm   170 ATFFRQPHFCSLCSDFMWGLNKQGYQCQLCSAAVHKKCHEKVIMQCPGSAKNTKETMALKERFKV 234

  Fly   567 PVP----------------LPPLPYEAMSGG--AEACETHDH----------------------- 590
            .:|                ...:.|.....|  .|.|....|
 Worm   235 DIPHRFKTYNFKSPTFCDHCGSMLYGLFKQGLRCEVCNVACHHKCERLMSNLCGVNQKQLSEMYH 299

  Fly   591 -----AHIVAPPPP---------------------------------EDPLE------------P 605
                 .|..|..||                                 |:..|            .
 Worm   300 EIKRGTHATASCPPNIANLHLNGETSKNNGSLPNKLKNLFKSHQYSVEEQKETDEYMDNIWGGGD 364

  Fly   606 GTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFET 670
            |..::::|..|.|::|:|:||:.||::|||:.....||||.:||.::.:|:|.:....|:.|...
 Worm   365 GPVKKFALPHFNLLKVLGKGSFGKVMLVELKGKNEFYAMKCLKKDVILEDDDTECTYIERRVLIL 429

  Fly   671 ASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKG 735
            ||..|||..|...|||...||||:|::.|||||:|:|:.::..|...||||.||.:||.|||...
 Worm   430 ASQCPFLCQLFCSFQTNEYLFFVMEYLNGGDLMHHIQQIKKFDEARTRFYACEIVVALQFLHTNN 494

  Fly   736 IIYRDLKLDNVLLDHEGHIKLTDYGMCK-EGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWW 799
            ||||||||||||||.:|||||.|:||.| |..|.....|||||||:||:|||::|:.|..:||:|
 Worm   495 IIYRDLKLDNVLLDCDGHIKLADFGMAKTEMNRENGMASTFCGTPDYISPEIIKGQLYNEAVDFW 559

  Fly   800 ALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPA 864
            :.|||:||||.|:|||...|         ||.||..||.:....|:::|..||..|....::||.
 Worm   560 SFGVLMYEMLVGQSPFHGEG---------EDELFDSILNERPYFPKTISKEAAKCLSALFDRNPN 615

  Fly   865 DRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTP-D 928
            .|||. .|.....|..|.||:.:||:..|.:||.|||||.:.|:.|.:||..:||.|...||| .
 Worm   616 TRLGM-PECPDGPIRQHCFFRGVDWKRFENRQVPPPFKPNIKSNSDASNFDDDFTNEKAALTPVH 679

  Fly   929 DDHVIDNIDQSEFEGFEYVNP 949
            |.:::.:||...|..|.|.||
 Worm   680 DKNLLASIDPEAFLNFSYTNP 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	23/51 (45%)
		S_TKc	616..884	CDD:214567	127/268 (47%)
		STKc_aPKC	620..947	CDD:270740	152/328 (46%)
tpa-1	NP_001379590.1	C1_nPKC_theta-like_rpt1	159..219	CDD:410384	24/59 (41%)
		C1_nPKC_theta-like_rpt2	238..287	CDD:410387	5/48 (10%)
		STKc_nPKC_theta_like	379..700	CDD:270744	153/330 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920