Protein Alignment aPKC and pkc-3

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_495011.1
• Gene: pkc-3 / 173914
• WormBaseID: WBGene00004034
• Length: 597
• Species: Caenorhabditis elegans
• Alignment Length: 532
• Identity: 315/532 - (59%)
• Similarity: 380/532 - (71%)
• Gaps: 36/532 - (6%)

  Fly   449 LQSEEEIEPAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAY 513
            |.|.:|.| ....||...|:.|||.|.|||:::||||||||:|:|..|||.|||||.|||..|..
 Worm    80 LNSSQEAE-LNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQCFI 143

  Fly   514 CQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPL----- 573
            |.|.|||:|||||:|:.|:|.||||||:.|:.||           .:....|..:|:.|.
 Worm   144 CHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHC-----------GQALQGPNIIPMAPASGSLK 197

  Fly   574 --------PYEAMSGGAEACETHDHAHIVAPPPPEDPLE-----PGTQR-QYSLNDFELIRVIGR 624
                    ......||.:....|:| .|.:|........     .|:.: ..|||||.|:.||||
 Worm   198 GARSNTSSSTTRSGGGIDNGAFHEH-EIESPGSTSHDASRAMNGNGSSKWAVSLNDFRLLTVIGR 261

  Fly   625 GSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSR 689
            ||||||:..|...||:|||:|:|||.:..:|||||||||||.|||.|||:||||||||||||.||
 Worm   262 GSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESR 326

  Fly   690 LFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHI 754
            ||||||||.|||||:|||:||:|||||||||:.||.|||:|||.:|||||||||||||:|.||||
 Worm   327 LFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHI 391

  Fly   755 KLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAG 819
            ||||||||||.|:.||.||||||||||||||||||::|||||||||||||::||:|||||||:.|
 Worm   392 KLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVG 456

  Fly   820 ASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRE--SAFMDIVSHP 882
             .:|.::||||||||:|||:.|||||||||||:.:|||||||:|.:||||..:  ....|:..|.
 Worm   457 -MQNSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQ 520

  Fly   883 FFKN-MDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEY 946
            ||:. :|||.||:|.|.||:.|.::|||||.:|..:||.|..||:||:..||..||||||:||||
 Worm   521 FFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEY 585

  Fly   947 VNPLLMSLEDCV 958
            ||||.||.||.|
 Worm   586 VNPLQMSREDSV 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	32/51 (63%)
		S_TKc	616..884	CDD:214567	197/269 (73%)
		STKc_aPKC	620..947	CDD:270740	231/329 (70%)
pkc-3	NP_495011.1	PB1_aPKC	13..95	CDD:99725	6/15 (40%)
		C1_1	128..178	CDD:278556	32/60 (53%)
		S_TKc	253..522	CDD:214567	197/269 (73%)
		PKc_like	257..586	CDD:304357	231/329 (70%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165938
Domainoid	1	1.000	410	1.000	Domainoid score	I349
eggNOG	1	0.900	-	-		E2759_KOG0695
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37667
Inparanoid	1	1.050	678	1.000	Inparanoid score	I369
Isobase	1	0.950	-	0	Normalized mean entropy	S926
OMA	1	1.010	-	-		QHG45540
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003559
OrthoInspector	1	1.000	-	-		oto20164
orthoMCL	1	0.900	-	-		OOG6_104397
Panther	1	1.100	-	-	LDO	PTHR24356
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2434
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.750