Protein Alignment aPKC and pkc-3

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_495011.1
• Gene: pkc-3 / 173914
• WormBaseID: WBGene00004034
• Length: 597
• Species: Caenorhabditis elegans
• Alignment Length: 532
• Identity: 315/532 - (59%)
• Similarity: 380/532 - (71%)
• Gaps: 36/532 - (6%)

  Fly   449 LQSEEEIEPAYATVFPNVPQAPGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAY 513
            |.|.:|.| ....||...|:.|||.|.|||:::||||||||:|:|..|||.|||||.|||..|..
 Worm    80 LNSSQEAE-LNIHVFVGKPELPGLPCQGEDKTVYRRGARRWKKIYLYNGHRFQAKRLNRRIQCFI 143

  Fly   514 CQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAEESSDPIPVPLPPL----- 573
            |.|.|||:|||||:|:.|:|.||||||:.|:.||           .:....|..:|:.|.
 Worm   144 CHDYIWGIGRQGFRCVDCRLCVHKKCHRHVRTHC-----------GQALQGPNIIPMAPASGSLK 197

  Fly   574 --------PYEAMSGGAEACETHDHAHIVAPPPPEDPLE-----PGTQR-QYSLNDFELIRVIGR 624
                    ......||.:....|:| .|.:|........     .|:.: ..|||||.|:.||||
 Worm   198 GARSNTSSSTTRSGGGIDNGAFHEH-EIESPGSTSHDASRAMNGNGSSKWAVSLNDFRLLTVIGR 261

  Fly   625 GSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSR 689
            ||||||:..|...||:|||:|:|||.:..:|||||||||||.|||.|||:||||||||||||.||
 Worm   262 GSYAKVVQAEHVSTRQIYAIKIIKKEMFNEDEDIDWVQTEKSVFEAASNYPFLVGLHSCFQTESR 326

  Fly   690 LFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHI 754
            ||||||||.|||||:|||:||:|||||||||:.||.|||:|||.:|||||||||||||:|.||||
 Worm   327 LFFVIEFVPGGDLMFHMQQQRKLPEEHARFYSGEIILALHFLHSRGIIYRDLKLDNVLIDAEGHI 391

  Fly   755 KLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAG 819
            ||||||||||.|:.||.||||||||||||||||||::|||||||||||||::||:|||||||:.|
 Worm   392 KLTDYGMCKENIKDGDLTSTFCGTPNYIAPEILRGDEYGFSVDWWALGVLMFEMMAGRSPFDIVG 456

  Fly   820 ASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRE--SAFMDIVSHP 882
             .:|.::||||||||:|||:.|||||||||||:.:|||||||:|.:||||..:  ....|:..|.
 Worm   457 -MQNSEENTEDYLFQIILERQIRIPRSLSVRASGILKGFLNKDPTERLGCKLDINEGLRDMKEHQ 520

  Fly   883 FFKN-MDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEGFEY 946
            ||:. :|||.||:|.|.||:.|.::|||||.:|..:||.|..||:||:..||..||||||:||||
 Worm   521 FFRGFIDWEALEQKAVAPPYHPAVESDRDLTHFDHQFTDELPQLSPDNPDVIARIDQSEFDGFEY 585

  Fly   947 VNPLLMSLEDCV 958
            ||||.||.||.|
 Worm   586 VNPLQMSREDSV 597

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	34/53 (64%)
		STKc_aPKC	620..947	CDD:270740	231/329 (70%)
pkc-3	NP_495011.1	PB1_aPKC	13..95	CDD:99725	6/15 (40%)
		C1_aPKC	126..180	CDD:410344	34/64 (53%)
		STKc_aPKC	257..586	CDD:270740	231/329 (70%)