DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and Sgk3

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001362972.1	Gene:	Sgk3 / 171498	RGDID:	620242	Length:	496	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	176/515 - (34%)
Similarity:	274/515 - (53%)	Gaps:	73/515 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   470 PGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLL 534
            |.:|....|.  :|...:|: .:|:|...:.:::.|..|.:..:  |:::...::.|..:..|:
  Rat    14 PSVSIPSSDE--HREKKKRF-TVYKVLVSVGRSEWFVFRRYAEF--DKLYNSLKKQFPAMALKI- 72

  Fly   535 VHKKCHKLVQKHCTDQPEP-LVKERAEESSDPIP--VPLPPLPYEAMSGGAEACETHDHAHIVA- 595
                   ..::...|..:| .:|:|....::.|.  |..|              |.::|..:.|
  Rat    73 -------PAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYP--------------ELYNHPDVRAF 116

  Fly   596 ---------PPPPEDPLEPGTQRQYSL----------------NDFELIRVIGRGSYAKVLMVEL 635
                     ..|.||..|..|.:.:|.                :||:.::|||:||:.|||:.:.
  Rat   117 LQMDSPRHQSDPSEDEDERSTPKPHSTSRNINLGPTGNPHAKPSDFDFLKVIGKGSFGKVLLAKR 181

  Fly   636 RRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGG 700
            :...:.||:||::|.:|.:.::...:..|::|......||||||||..|||..:|:||::||.||
  Rat   182 KLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246

  Fly   701 DLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            :|.:|:||:|..||..||||||||:.||.:||...|:|||||.:|:|||..||:.|||:|:||||
  Rat   247 ELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEG 311

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
            |...|||:||||||.|:|||::|.:.|..:||||.||.:|||||.|..||.....:|
  Rat   312 IAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE-------- 368

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
             ::..||.|.:.:...:|:.|.|:|:..|.||..:|||...:  |::|.:||||:::.|..|.:|
  Rat   369 -MYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGAKED--FLEIQNHPFFESLSWTDLVQK 430

  Fly   896 QVTPPFKPRLDSDRDLANFPPEFTGEAV--QLTPDDDHVIDNIDQSE----FEGFEYVNP 949
            ::.|||.|.:....|:.||...||.|.|  .:....|:.|.|....|    |.||.|..|
  Rat   431 KIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	5/51 (10%)
		S_TKc	616..884	CDD:214567	122/267 (46%)
		STKc_aPKC	620..947	CDD:270740	144/332 (43%)
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780	22/132 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	121..157		6/35 (17%)
		STKc_SGK3	165..490	CDD:270755	145/335 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		2/9 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910