Protein Alignment aPKC and Sgk3

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001362972.1
• Gene: Sgk3 / 171498
• RGDID: 620242
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 515
• Identity: 176/515 - (34%)
• Similarity: 274/515 - (53%)
• Gaps: 73/515 - (14%)

  Fly   470 PGLSCDGEDRSIYRRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLL 534
            |.:|....|.  :|...:|: .:|:|...:.:::.|..|.:..:  |:::...::.|..:..|:
  Rat    14 PSVSIPSSDE--HREKKKRF-TVYKVLVSVGRSEWFVFRRYAEF--DKLYNSLKKQFPAMALKI- 72

  Fly   535 VHKKCHKLVQKHCTDQPEP-LVKERAEESSDPIP--VPLPPLPYEAMSGGAEACETHDHAHIVA- 595
                   ..::...|..:| .:|:|....::.|.  |..|              |.::|..:.|
  Rat    73 -------PAKRIFGDNFDPDFIKQRRAGLNEFIQNLVRYP--------------ELYNHPDVRAF 116

  Fly   596 ---------PPPPEDPLEPGTQRQYSL----------------NDFELIRVIGRGSYAKVLMVEL 635
                     ..|.||..|..|.:.:|.                :||:.::|||:||:.|||:.:.
  Rat   117 LQMDSPRHQSDPSEDEDERSTPKPHSTSRNINLGPTGNPHAKPSDFDFLKVIGKGSFGKVLLAKR 181

  Fly   636 RRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGG 700
            :...:.||:||::|.:|.:.::...:..|::|......||||||||..|||..:|:||::||.||
  Rat   182 KLDGKFYAVKVLQKKIVLNRKEQKHIMAERNVLLKNVKHPFLVGLHYSFQTTEKLYFVLDFVNGG 246

  Fly   701 DLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEG 765
            :|.:|:||:|..||..||||||||:.||.:||...|:|||||.:|:|||..||:.|||:|:||||
  Rat   247 ELFFHLQRERSFPEPRARFYAAEIASALGYLHSIKIVYRDLKPENILLDSMGHVVLTDFGLCKEG 311

  Fly   766 IRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTED 830
            |...|||:||||||.|:|||::|.:.|..:||||.||.:|||||.|..||.....:|
  Rat   312 IAISDTTTTFCGTPEYLAPEVIRKQPYDNTVDWWCLGAVLYEMLYGLPPFYCRDVAE-------- 368

  Fly   831 YLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERK 895
             ::..||.|.:.:...:|:.|.|:|:..|.||..:|||...:  |::|.:||||:::.|..|.:|
  Rat   369 -MYDNILHKPLNLRPGVSLTAWSILEELLEKNRQNRLGAKED--FLEIQNHPFFESLSWTDLVQK 430

  Fly   896 QVTPPFKPRLDSDRDLANFPPEFTGEAV--QLTPDDDHVIDNIDQSE----FEGFEYVNP 949
            ::.|||.|.:....|:.||...||.|.|  .:....|:.|.|....|    |.||.|..|
  Rat   431 KIPPPFNPNVAGPDDIRNFDAVFTEETVPYSVCVSSDYSIVNASVLEADDAFVGFSYAPP 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	5/53 (9%)
		STKc_aPKC	620..947	CDD:270740	144/332 (43%)
Sgk3	NP_001362972.1	PX_CISK	12..120	CDD:132780	22/132 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	121..157		6/35 (17%)
		STKc_SGK3	165..490	CDD:270755	145/335 (43%)
		Nuclear localization signal. /evidence=ECO:0000250	195..205		2/9 (22%)