Protein Alignment aPKC and Prkcd

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_579841.2
• Gene: Prkcd / 170538
• RGDID: 67383
• Length: 673
• Species: Rattus norvegicus
• Alignment Length: 614
• Identity: 223/614 - (36%)
• Similarity: 315/614 - (51%)
• Gaps: 120/614 - (19%)

  Fly   429 PIPTVPMGVAPSSQQMSQHQLQSEEEIEPAYATVFPNVPQAPGLSC------DG--------EDR 479
            |:..|.:||:..:::..::..::|..::..        |||..|.|      ||        |:.
  Rat    80 PMSEVTVGVSVLAERCKKNNGKAEFWLDLQ--------PQAKVLMCVQYFLEDGDCKQSMRSEEE 136

  Fly   480 SIY----RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCH 540
            :::    ||||.:..|::.:..|.|.|..|.:..||:.|::.:|||.:||:||.||...:||||.
  Rat   137 AMFPTMNRRGAIKQAKIHYIKNHEFIATFFGQPTFCSVCKEFVWGLNKQGYKCRQCNAAIHKKCI 201

  Fly   541 KLVQKHCT-----DQPEPLVKERAEESSDPIPVPLPPLPYEAMS-------GG-----------A 582
            ..:...||     .:.....|||..     |.:|.....|..||       |.           .
  Rat   202 DKIIGRCTGTATNSRDTIFQKERFN-----IDMPHRFKVYNYMSPTFCDHCGSLLWGLVKQGLKC 261

  Fly   583 EACETHDH-------AHIV-----------------APPPPEDPLEPGTQRQYS----------- 612
            |.|..:.|       |::.                 |...||.|...|..:.:.
  Rat   262 EDCGMNVHHKCREKVANLCGINQKLLAEALNQVTQKASRKPETPETVGIYQGFEKKTAVSGNDIP 326

  Fly   613 -----------------LNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDW 660
                             |.:|...:|:|:||:.|||:.||:...|.:|:|.:||.:|..|:|::.
  Rat   327 DNNGTYGKIWEGSNRCRLENFTFQKVLGKGSFGKVLLAELKGKERYFAIKYLKKDVVLIDDDVEC 391

  Fly   661 VQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEIS 725
            ...||.|...|..:|||..|...|||...||||:||:.|||||:|:|.:.|.....|.||||||.
  Rat   392 TMVEKRVLALAWENPFLTHLICTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFELYRATFYAAEII 456

  Fly   726 LALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGE 790
            ..|.|||.|||||||||||||:||.:||||:.|:|||||.|...:..|||||||:|||||||:|.
  Rat   457 CGLQFLHGKGIIYRDLKLDNVMLDKDGHIKIADFGMCKENIFGENRASTFCGTPDYIAPEILQGL 521

  Fly   791 DYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVL 855
            .|.||||||:.||||||||.|:|||         ..:.||.||:.|...|...||.::..:..::
  Rat   522 KYSFSVDWWSFGVLLYEMLIGQSPF---------HGDDEDELFESIRVDTPHYPRWITKESKDIM 577

  Fly   856 KGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTG 920
            :....::||.|||     ...:|..|||||.::|.|||:::|.|||||::.|..|.:||.|||..
  Rat   578 EKLFERDPAKRLG-----VTGNIRLHPFFKTINWNLLEKRKVEPPFKPKVKSPSDYSNFDPEFLN 637

  Fly   921 EAVQLTPDDDHVIDNIDQSEFEGFEYVNP 949
            |..||:..|.::||::||:.|:||.:|||
  Rat   638 EKPQLSFSDKNLIDSMDQTAFKGFSFVNP 666

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	22/58 (38%)
		STKc_aPKC	620..947	CDD:270740	160/326 (49%)
Prkcd	NP_579841.2	C1_nPKC_theta-like_rpt1	152..212	CDD:410384	23/59 (39%)
		C1_nPKC_theta-like_rpt2	231..280	CDD:410387	8/48 (17%)
		Protein Kinases, catalytic domain	351..666	CDD:473864	161/328 (49%)