Protein Alignment aPKC and Pkc98E

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_061497978.1
• Gene: Pkc98E / 1273220
• VectorBaseID: AGAMI1_006338
• Length: 767
• Species: Anopheles gambiae
• Alignment Length: 611
• Identity: 237/611 - (38%)
• Similarity: 307/611 - (50%)
• Gaps: 156/611 - (25%)

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 547
            ||||.| |::::||||.|.|....:..||::|::.|||||:||::|..|..:|||:||..|...|
Mosquito   159 RRGAMR-RRVHQVNGHKFMATFLRQPTFCSHCREFIWGLGKQGYQCQVCTCVVHKRCHSSVVTKC 222

  Fly   548 TDQPEPLVKERAEESSDPIPVPLP------------------PLPYEAMSGG--AEACETHDHAH 592
            ..:.:...|....|::....|.:|                  .|.|..:..|  .|.|..:.|..
Mosquito   223 PKKKDEQTKPTPTEAAQRFNVNMPHRFSVHSFKRLTFCDHCGSLLYGIIRQGLKCEVCSMNIHRR 287

  Fly   593 ------------------------IVAPPPPEDPLEPGTQR-------------------QYS-- 612
                                    |.....|....:.|..|                   |||
Mosquito   288 CEGNVANNCGINTKQLAELLNEMGITMDKTPPRRSKVGEVRCIKMQHSLLMLTYFSFICNQYSNQ 352

  Fly   613 ----------------------------------------------------------------- 612
                                                                             
Mosquito   353 TTSDNLSMSERSDDTSSLDTLSTKSGAEGELGAHGGGGGGGGRGGAGHSSKAGGPTMGMLVNLGT 417

  Fly   613 --------------LNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQT 663
                          ||||..|:|:|:||:.||::.|.:.|..:||:||:||.::..|:|:|...|
Mosquito   418 DDDGNARPMPGKVFLNDFNFIKVLGKGSFGKVMLAEKKGTDEVYAIKVLKKDVILQDDDVDCTMT 482

  Fly   664 EKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLAL 728
            ||.:...|:.||||..||||||||.|||||:|:|.|||||:.:||.|:..|..|.|||||::|||
Mosquito   483 EKRILALAAKHPFLTALHSCFQTPDRLFFVMEYVNGGDLMFQIQRARKFDEPRAAFYAAEVTLAL 547

  Fly   729 NFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYG 793
            .|||..|:|||||||||:|||.|||.||.|:|||||||...:.||||||||:|||||||:..|||
Mosquito   548 QFLHRNGVIYRDLKLDNILLDAEGHCKLADFGMCKEGITGDNLTSTFCGTPDYIAPEILQELDYG 612

  Fly   794 FSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGF 858
            .||||||||||:|||:||:.||         :.:.||.||:.||...:..|..||..|.|:||||
Mosquito   613 PSVDWWALGVLMYEMMAGQPPF---------EADNEDDLFEAILRDDVLYPVWLSREAVSILKGF 668

  Fly   859 LNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAV 923
            :.||.|.||||  ......|.||||||:||||.||:::|.|||:||:.|.||..||..|||.|..
Mosquito   669 MTKNAAKRLGC--TDGENQIRSHPFFKDMDWEALEQRKVRPPFRPRVRSARDALNFDTEFTKEDP 731

  Fly   924 QLTPDDDHVIDNIDQSEFEGFEYVNP 949
            .|||..:.:|..|:|.||.||.:.||
Mosquito   732 VLTPVPNDIIRCINQDEFAGFSFTNP 757

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	24/53 (45%)
		STKc_aPKC	620..947	CDD:270740	182/326 (56%)
Pkc98E	XP_061497978.1	None