Protein Alignment aPKC and akt1

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001268730.1
• Gene: akt1 / 101910198
• ZFINID: ZDB-GENE-130730-1
• Length: 474
• Species: Danio rerio
• Alignment Length: 427
• Identity: 165/427 - (38%)
• Similarity: 247/427 - (57%)
• Gaps: 42/427 - (9%)

  Fly   527 KCIQCKLLVHKKCHKLVQKHCTDQPEPLVKERAE--ESSDPIPVPLPPLPYEAMSGGAEACETHD 589
            :|:|...::.:..|       .:.||    ||.|  ::...:...|.....|.|...||    |.
Zfish    77 RCLQWTTVIERTFH-------VETPE----ERQEWTKAIQTVAESLQKQEEEMMDASAE----HT 126

  Fly   590 HAHIVAPPPPEDPLEPGTQRQYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTD 654
            ........||         .:.:::|||.::::|:|::.||::|:.:.|.:.||||::||.::..
Zfish   127 DMETSLSKPP---------HKVTMHDFEYLKLLGKGTFGKVILVKEKATGKYYAMKILKKEVIVA 182

  Fly   655 DEDIDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARF 719
            .:::....||..|.:. |.||||..|.|.|||...|.||:|:..||:|.:|:.|:|...||.|.|
Zfish   183 KDEVAHTLTENRVLQN-SRHPFLTALKSSFQTHDHLCFVMEYANGGELFFHLSRERVFSEERACF 246

  Fly   720 YAAEISLALNFLH-EKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIA 783
            |.|||..||::|| |:.::||||||:|::||.:||:|:||:|:|||||..|.|..||||||.|:|
Zfish   247 YGAEIVSALHYLHSERNVVYRDLKLENLMLDKDGHVKITDFGLCKEGITDGATMKTFCGTPEYLA 311

  Fly   784 PEILRGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLS 848
            ||:|...|||.:||||.|||::|||:.||.||      .|.|   .:.||::||.:.||.||:|:
Zfish   312 PEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPF------YNQD---HERLFELILMEDIRFPRTLA 367

  Fly   849 VRAASVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLAN 913
            ..|.|:|.|.|.|:|..|||...:.| .:|:.|.||..:.|:.:..|::.|||||::.|:.|...
Zfish   368 PDAKSLLSGLLKKDPMQRLGGGPDDA-KEIMQHKFFTGIVWQDVYEKKLVPPFKPQVTSETDTRY 431

  Fly   914 FPPEFTGEAVQLTP--DDD--HVIDNIDQSEFEGFEY 946
            |..||||:.:.:||  .||  ...|:..:..|..|.|
Zfish   432 FDEEFTGQTITITPPGQDDCMEAFDSERRPHFPQFSY 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	3/22 (14%)
		STKc_aPKC	620..947	CDD:270740	146/332 (44%)
akt1	NP_001268730.1	PH_PKB	5..112	CDD:269947	8/45 (18%)
		Protein Kinases, catalytic domain	120..473	CDD:473864	154/373 (41%)