Protein Alignment aPKC and prkcab

DIOPT Version :9

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_009298084.1
• Gene: prkcab / 100333967
• ZFINID: ZDB-GENE-131121-412
• Length: 681
• Species: Danio rerio
• Alignment Length: 661
• Identity: 224/661 - (33%)
• Similarity: 301/661 - (45%)
• Gaps: 205/661 - (31%)

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 547
            |:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|..|..:|||:||:.|...|
Zfish    20 RKGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVSFSC 84

  Fly   548 --------TDQPEPLVKERAEESSDP----------------------------------IP--- 567
                    ||.|....|.:......|                                  :|
Zfish    85 PGADKGPDTDDPRSKHKFKIHSYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVMNVPSLC 149

  Fly   568 --------------------------------VPLPPL----PY--------------------- 575
                                            :|:.|.    ||
Zfish   150 GTDHTERRGRIFMKIEVSGDRLHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPKNETKQKTRTIR 214

  Fly   576 ----------------------------------------EAMSGGA------------------ 582
                                                    .:||.|.
Zfish   215 SSLNPTWNESFIFKLKASDKERRLSVEVWDWDRTTRNDFMGSMSFGVSELIKAPVSGWYKMLNQE 279

  Fly   583 -----------------------EACETHDHAHIVAP-PPPEDPLEPGTQRQYS----------L 613
                                   |||:.:.|....|. .|.:..:.|...|::|          |
Zfish   280 EGEYYNVPIPEENDINLELRQKFEACQFNIHLLKKAKLGPGKKVITPTDHRRFSLPSGNMDKVRL 344

  Fly   614 NDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLV 678
            |||..:.::|:||:.||::.|::.|..:||:|::||.:|..|:|::....||.|.......|||.
Zfish   345 NDFHFLALLGKGSFGKVMLAEMKSTEELYAIKILKKDVVIQDDDVECTMVEKRVLAQREKPPFLT 409

  Fly   679 GLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKL 743
            .|||||||..||:||:|::.|||||||:|:..:..|..|.||||||::.|.|||.||||||||||
Zfish   410 QLHSCFQTVDRLYFVMEYINGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHRKGIIYRDLKL 474

  Fly   744 DNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEM 808
            |||:||.|||||:.|:|||||.:..|.||.||||||:||||||:..:.||.||||||.|||||||
Zfish   475 DNVMLDSEGHIKIADFGMCKENMYEGMTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM 539

  Fly   809 LAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRES 873
            |||:.||         |...||.|||.|:|..:..|:||:..|.|:.||.:.|:|:.||||..|.
Zfish   540 LAGQPPF---------DGEDEDELFQSIMEHNVSYPKSLTKEAVSICKGLMTKHPSKRLGCGAEG 595

  Fly   874 AFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQ 938
            . .||....||:.:||:.|..:::.|||||:: ..:...||...||.....|||.|..||.||||
Zfish   596 E-RDIKEQAFFRRIDWDRLANREIQPPFKPKV-CGKAAENFDKFFTRTQPMLTPPDQLVIANIDQ 658

  Fly   939 SEFEGFEYVNP 949
            |||.||.::||
Zfish   659 SEFAGFSFINP 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	25/59 (42%)
		S_TKc	616..884	CDD:214567	139/267 (52%)
		STKc_aPKC	620..947	CDD:270740	167/326 (51%)
prkcab	XP_009298084.1	C1_1	35..87	CDD:278556	24/51 (47%)
		C1_1	100..150	CDD:278556	3/49 (6%)
		C2_PKC_alpha_gamma	157..287	CDD:175992	7/129 (5%)
		S_TKc	347..605	CDD:214567	139/267 (52%)
		STKc_cPKC	350..668	CDD:270739	167/328 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143719at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920