Protein Alignment aPKC and prkcab

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: XP_009298084.1
• Gene: prkcab / 100333967
• ZFINID: ZDB-GENE-131121-412
• Length: 681
• Species: Danio rerio
• Alignment Length: 661
• Identity: 224/661 - (33%)
• Similarity: 301/661 - (45%)
• Gaps: 205/661 - (31%)

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 547
            |:||.|.:.::.|..|.|.|:.|.:..||::|.|.|||.|:|||:|..|..:|||:||:.|...|
Zfish    20 RKGALRQKNVHEVKNHKFIARFFKQPTFCSHCTDFIWGFGKQGFQCQVCCFVVHKRCHEFVSFSC 84

  Fly   548 --------TDQPEPLVKERAEESSDP----------------------------------IP--- 567
                    ||.|....|.:......|                                  :|
Zfish    85 PGADKGPDTDDPRSKHKFKIHSYGSPTFCDHCGSLLYGLIHQGMKCDTCDMNVHKQCVMNVPSLC 149

  Fly   568 --------------------------------VPLPPL----PY--------------------- 575
                                            :|:.|.    ||
Zfish   150 GTDHTERRGRIFMKIEVSGDRLHVTVGEARNLIPMDPNGLSDPYVKLKLIPDPKNETKQKTRTIR 214

  Fly   576 ----------------------------------------EAMSGGA------------------ 582
                                                    .:||.|.
Zfish   215 SSLNPTWNESFIFKLKASDKERRLSVEVWDWDRTTRNDFMGSMSFGVSELIKAPVSGWYKMLNQE 279

  Fly   583 -----------------------EACETHDHAHIVAP-PPPEDPLEPGTQRQYS----------L 613
                                   |||:.:.|....|. .|.:..:.|...|::|          |
Zfish   280 EGEYYNVPIPEENDINLELRQKFEACQFNIHLLKKAKLGPGKKVITPTDHRRFSLPSGNMDKVRL 344

  Fly   614 NDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLV 678
            |||..:.::|:||:.||::.|::.|..:||:|::||.:|..|:|::....||.|.......|||.
Zfish   345 NDFHFLALLGKGSFGKVMLAEMKSTEELYAIKILKKDVVIQDDDVECTMVEKRVLAQREKPPFLT 409

  Fly   679 GLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKL 743
            .|||||||..||:||:|::.|||||||:|:..:..|..|.||||||::.|.|||.||||||||||
Zfish   410 QLHSCFQTVDRLYFVMEYINGGDLMYHIQQVGKFKEPQAVFYAAEIAVGLFFLHRKGIIYRDLKL 474

  Fly   744 DNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEM 808
            |||:||.|||||:.|:|||||.:..|.||.||||||:||||||:..:.||.||||||.|||||||
Zfish   475 DNVMLDSEGHIKIADFGMCKENMYEGMTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEM 539

  Fly   809 LAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRES 873
            |||:.||         |...||.|||.|:|..:..|:||:..|.|:.||.:.|:|:.||||..|.
Zfish   540 LAGQPPF---------DGEDEDELFQSIMEHNVSYPKSLTKEAVSICKGLMTKHPSKRLGCGAEG 595

  Fly   874 AFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQ 938
            . .||....||:.:||:.|..:::.|||||:: ..:...||...||.....|||.|..||.||||
Zfish   596 E-RDIKEQAFFRRIDWDRLANREIQPPFKPKV-CGKAAENFDKFFTRTQPMLTPPDQLVIANIDQ 658

  Fly   939 SEFEGFEYVNP 949
            |||.||.::||
Zfish   659 SEFAGFSFINP 669

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	25/61 (41%)
		STKc_aPKC	620..947	CDD:270740	167/326 (51%)
prkcab	XP_009298084.1	C1_cPKC_rpt1	33..90	CDD:410383	24/56 (43%)
		C1_cPKC_rpt2	100..153	CDD:410386	3/52 (6%)
		C2_PKC_alpha_gamma	157..287	CDD:175992	7/129 (5%)
		STKc_cPKC	350..668	CDD:270739	167/328 (51%)