DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aPKC and prkcdb

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001352166.1	Gene:	prkcdb / 100150844	ZFINID:	ZDB-GENE-111129-1	Length:	685	Species:	Danio rerio

Alignment Length:	559	Identity:	204/559 - (36%)
Similarity:	292/559 - (52%)	Gaps:	104/559 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   483 RRGARRWRKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGLGRQGFKCIQCKLLVHKKCHKLVQKHC 547
            ||||.:..|::.:..|.|.|..|.:..||:.|::.:|||.:||:||.||...:||||...:...|
Zfish   145 RRGAIKQAKVHFIKNHEFTATFFKQPTFCSVCREFVWGLNKQGYKCRQCNAAIHKKCIDKIIGRC 209

  Fly   548 T-----DQPEPLVKERAEESSDPIPVP--------LPP--------LPYEAMSGG--AEACETHD 589
            |     .:.....|||.:     |.:|        :.|        |.:..:..|  .|.|..:.
Zfish   210 TGTATNSRDTMFQKERFK-----IDMPHRFKTNNYMSPTFCDHCGSLLWGMVKQGLKCEDCGMNV 269

  Fly   590 H-------AHIVA---------------------PPP---------------PEDPLEPGTQR-- 609
            |       |::..                     |.|               |.||...|:|.
Zfish   270 HHKCQTKVANLCGINQKLLAEALNQVSLKSSTKRPDPTLSEIGIYQAIDKNVPADPSAEGSQYGK 334

  Fly   610 -----------------QYSLNDFELIRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDED 657
                             :.|||||...:|:|:||:.||::.||:...:.:|:|.:||.:|..|:|
Zfish   335 FWDITPAVPASTIVSTVRVSLNDFVFQKVLGKGSFGKVMLAELKGKGQYFAIKALKKDVVLMDDD 399

  Fly   658 IDWVQTEKHVFETASNHPFLVGLHSCFQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAA 722
            ::....||.|...|..:|||..|:..||:...||||:|::.|||||:|:|.:.|.....|.||||
Zfish   400 VECTMVEKRVLALAWENPFLTHLYCTFQSKEHLFFVMEYLNGGDLMFHIQDKGRFDLYRATFYAA 464

  Fly   723 EISLALNFLHEKGIIYRDLKLDNVLLDHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEIL 787
            ||...|.:||.|||:|||||||||:||.:||||:.|:|||||.:...:..:||||||:|||||||
Zfish   465 EIICGLQYLHSKGIVYRDLKLDNVMLDKDGHIKIADFGMCKENMIGENRATTFCGTPDYIAPEIL 529

  Fly   788 RGEDYGFSVDWWALGVLLYEMLAGRSPFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAA 852
            .|:.|.||||||:.||||||||.|:|||         ..:.||.||..|.......||.::..|.
Zfish   530 LGQKYSFSVDWWSFGVLLYEMLIGQSPF---------QGDDEDELFDSIRMDVPHYPRWITKEAK 585

  Fly   853 SVLKGFLNKNPADRLGCHRESAFMDIVSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPE 917
            .:|:....::|..|||     ...:|..|.|||.::|..||:::|:|||||::.|..|.:||..|
Zfish   586 DLLEKLFERDPTRRLG-----VVGNIRGHAFFKTINWPALEKREVSPPFKPKVKSSSDCSNFDRE 645

  Fly   918 FTGEAVQLTPDDDHVIDNIDQSEFEGFEYVNPLLMSLED 956
            |..|..:|:..|.::||::||:.|.||.::||.:.||.|
Zfish   646 FLSEKPRLSQSDKNLIDSMDQTAFAGFSFINPKMESLID 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	22/56 (39%)
		S_TKc	616..884	CDD:214567	121/267 (45%)
		STKc_aPKC	620..947	CDD:270740	148/326 (45%)
prkcdb	NP_001352166.1	C1_1	160..209	CDD:278556	20/48 (42%)
		C1_1	232..284	CDD:278556	7/51 (14%)
		PKc_like	362..677	CDD:328722	148/328 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920