Protein Alignment aPKC and prkcha

DIOPT Version :10

• Sequence 1: NP_001260984.1
• Gene: aPKC / 47594
• FlyBaseID: FBgn0261854
• Length: 958
• Species: Drosophila melanogaster
• Sequence 2: NP_001116528.1
• Gene: prkcha / 100144561
• ZFINID: ZDB-GENE-080402-5
• Length: 712
• Species: Danio rerio
• Alignment Length: 531
• Identity: 222/531 - (41%)
• Similarity: 314/531 - (59%)
• Gaps: 76/531 - (14%)

  Fly   490 RKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL-GRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEP 553
            ||:::||||.|.:....:..||.:|::.|||: |:||::|..|..:|||:||:||...|....:|
Zfish   161 RKIHQVNGHKFMSTFLKQPTFCFHCKEFIWGVFGKQGYQCQVCTCVVHKRCHQLVVTVCPRMKKP 225

  Fly   554 LVKERAEESSDPIPVP---------LP-------PLPYEAMSGG--AEACETHDHAHI---VAP- 596
             .||::......|.||         :|       .|.:..:..|  .:.|:.:.|...   |||
Zfish   226 -AKEQSTTQGFSINVPHKFSIHNYKVPTFCDHCGSLLWGIVRQGLHCKICKMNVHIRCKGNVAPN 289

  Fly   597 ----------PPPEDPLEPG--TQR------------------------------QYSLNDFELI 619
                      ...|..|:||  |:|                              :..:::|.|:
Zfish   290 CGINNVELANKLAEMGLQPGGLTKRNSVGLAGLDAQSRTLSVRGERGQSKKEQCLKLGISNFTLL 354

  Fly   620 RVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCF 684
            :|:|:||:.||::|.|..:.:::|:|::||.::..|:|::...|||.|...||.||:|..|:.||
Zfish   355 QVLGKGSFGKVMLVRLNGSDQVFAVKILKKDIILQDDDVECTMTEKRVLSLASTHPYLTQLYCCF 419

  Fly   685 QTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLD 749
            |||.|||||:|||.|||||:|:|:.|:..|..||||.|||:.||.|||.|||:||||||||||||
Zfish   420 QTPERLFFVMEFVNGGDLMFHIQKSRKFEENRARFYTAEITSALIFLHSKGIVYRDLKLDNVLLD 484

  Fly   750 HEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSP 814
            .:||.||.|:||||||:..|..|.||||||:|||||||:...||.|||||||||||||||:|.:|
Zfish   485 KDGHCKLADFGMCKEGMFDGIVTGTFCGTPDYIAPEILQELLYGPSVDWWALGVLLYEMLSGHAP 549

  Fly   815 FDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGC-HRESAFMDI 878
            |:    :||     ||.||:.||.:.|.....||..|..:|||||.|||:.|||| ..|.....:
Zfish   550 FE----AEN-----EDDLFESILTEEIIYASWLSTNAVDILKGFLTKNPSRRLGCVATEGGETAV 605

  Fly   879 VSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEG 943
            ..||||.::||:.|:::.:.||||||:.:..|:.||.|:||.|...|||.|:.::.:|.|.:|.|
Zfish   606 TGHPFFTDIDWDKLDQRALEPPFKPRIKTAEDVNNFDPDFTQEDPTLTPIDESILPSISQDDFRG 670

  Fly   944 FEYVNPLLMSL 954
            |.:.:..|:.:
Zfish   671 FSFTSSELLKM 681

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_aPKC	496..550	CDD:410344	23/54 (43%)
		STKc_aPKC	620..947	CDD:270740	173/327 (53%)
prkcha	NP_001116528.1	C2_PKC_epsilon	3..136	CDD:175981
		C1_nPKC_epsilon-like_rpt1	160..223	CDD:410385	26/61 (43%)
		C1_nPKC_epsilon-like_rpt2	239..293	CDD:410388	10/53 (19%)
		Protein Kinases, catalytic domain	355..678	CDD:473864	173/331 (52%)