DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and prkcha

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	NP_001116528.1	Gene:	prkcha / 100144561	ZFINID:	ZDB-GENE-080402-5	Length:	712	Species:	Danio rerio

Alignment Length:	531	Identity:	222/531 - (41%)
Similarity:	314/531 - (59%)	Gaps:	76/531 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   490 RKLYRVNGHIFQAKRFNRRAFCAYCQDRIWGL-GRQGFKCIQCKLLVHKKCHKLVQKHCTDQPEP 553
            ||:::||||.|.:....:..||.:|::.|||: |:||::|..|..:|||:||:||...|....:|
Zfish   161 RKIHQVNGHKFMSTFLKQPTFCFHCKEFIWGVFGKQGYQCQVCTCVVHKRCHQLVVTVCPRMKKP 225

  Fly   554 LVKERAEESSDPIPVP---------LP-------PLPYEAMSGG--AEACETHDHAHI---VAP- 596
             .||::......|.||         :|       .|.:..:..|  .:.|:.:.|...   |||
Zfish   226 -AKEQSTTQGFSINVPHKFSIHNYKVPTFCDHCGSLLWGIVRQGLHCKICKMNVHIRCKGNVAPN 289

  Fly   597 ----------PPPEDPLEPG--TQR------------------------------QYSLNDFELI 619
                      ...|..|:||  |:|                              :..:::|.|:
Zfish   290 CGINNVELANKLAEMGLQPGGLTKRNSVGLAGLDAQSRTLSVRGERGQSKKEQCLKLGISNFTLL 354

  Fly   620 RVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSCF 684
            :|:|:||:.||::|.|..:.:::|:|::||.::..|:|::...|||.|...||.||:|..|:.||
Zfish   355 QVLGKGSFGKVMLVRLNGSDQVFAVKILKKDIILQDDDVECTMTEKRVLSLASTHPYLTQLYCCF 419

  Fly   685 QTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLLD 749
            |||.|||||:|||.|||||:|:|:.|:..|..||||.|||:.||.|||.|||:||||||||||||
Zfish   420 QTPERLFFVMEFVNGGDLMFHIQKSRKFEENRARFYTAEITSALIFLHSKGIVYRDLKLDNVLLD 484

  Fly   750 HEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRSP 814
            .:||.||.|:||||||:..|..|.||||||:|||||||:...||.|||||||||||||||:|.:|
Zfish   485 KDGHCKLADFGMCKEGMFDGIVTGTFCGTPDYIAPEILQELLYGPSVDWWALGVLLYEMLSGHAP 549

  Fly   815 FDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGC-HRESAFMDI 878
            |:    :||     ||.||:.||.:.|.....||..|..:|||||.|||:.|||| ..|.....:
Zfish   550 FE----AEN-----EDDLFESILTEEIIYASWLSTNAVDILKGFLTKNPSRRLGCVATEGGETAV 605

  Fly   879 VSHPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFEG 943
            ..||||.::||:.|:::.:.||||||:.:..|:.||.|:||.|...|||.|:.::.:|.|.:|.|
Zfish   606 TGHPFFTDIDWDKLDQRALEPPFKPRIKTAEDVNNFDPDFTQEDPTLTPIDESILPSISQDDFRG 670

  Fly   944 FEYVNPLLMSL 954
            |.:.:..|:.:
Zfish   671 FSFTSSELLKM 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	21/52 (40%)
		S_TKc	616..884	CDD:214567	148/268 (55%)
		STKc_aPKC	620..947	CDD:270740	173/327 (53%)
prkcha	NP_001116528.1	C2_PKC_epsilon	3..136	CDD:175981
		C1_1	169..220	CDD:278556	20/50 (40%)
		C1_1	241..293	CDD:278556	8/51 (16%)
		S_TKc	351..611	CDD:214567	148/268 (55%)
		PKc_like	355..678	CDD:304357	173/331 (52%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920