DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aPKC and prkcea

DIOPT Version :9

Sequence 1:	NP_001260984.1	Gene:	aPKC / 47594	FlyBaseID:	FBgn0261854	Length:	958	Species:	Drosophila melanogaster
Sequence 2:	XP_005156350.1	Gene:	prkcea / 100005075	ZFINID:	ZDB-GENE-030131-8191	Length:	744	Species:	Danio rerio

Alignment Length:	654	Identity:	239/654 - (36%)
Similarity:	330/654 - (50%)	Gaps:	172/654 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 QQMSQHQLQSEEEIEP---AYATVFPNVPQAPGLSC-------DGEDRSI-------YRRGARRW 489
            |..|:| .:...::||   .|..:     ...|.||       :.|:|..       .|:||.|
Zfish   107 QNGSRH-FEDWIDLEPEGKVYVII-----DLSGSSCEAAASSNENEERVFRERMRPRKRQGAVR- 164

  Fly   490 RKLYRVNGHIFQAKRFNRRAFCAYCQDRIWG-LGRQGFKCIQCKLLVHKKCHKLVQKHCT----- 548
            |::::||||.|.|....:..:|::|:|.||| ||:||::|..|..:|||:||:|:...|.
Zfish   165 RRVHQVNGHKFMATYLRQPTYCSHCRDFIWGVLGKQGYQCQVCTCVVHKRCHELIITKCAGMKKQ 229

  Fly   549 -DQPEPLVKERAEESSDPIPVPLP------------------PLPYEAMSGG--AEACETHDHAH 592
             |.||       |..|....|.:|                  .|.:..|..|  .:||:.:.|..
Zfish   230 EDTPE-------EVGSQRFSVNIPHMFSIHNYKVPTFCDHCGSLLWGLMRQGLQCKACKMNVHRR 287

  Fly   593 I---VAP---------------------------------PPPEDPLEPGTQ------------- 608
            .   |||                                 .|.:||.:..|:
Zfish   288 CESNVAPSCGVDARKIAKVLSDLGVTPDKISNSTQRRKKLTPGQDPQQSTTEAPSSEESDRCKSA 352

  Fly   609 -------------------------------------------------------RQYSLNDFEL 618
                                                                   ::.||.||..
Zfish   353 PTSPCDQAELAELESIRKALSFGQEHKSSSSSSCSGVQSTEIEGRENGDLKTVQTKRMSLTDFSF 417

  Fly   619 IRVIGRGSYAKVLMVELRRTRRIYAMKVIKKALVTDDEDIDWVQTEKHVFETASNHPFLVGLHSC 683
            |:|:|:||:.||::.||:.|..:||:||:||.::..|:|:|...|||.:...|..||:|..|..|
Zfish   418 IKVLGKGSFGKVMLAELKGTDEVYAVKVLKKDVILQDDDVDCTLTEKRILALARKHPYLTQLFCC 482

  Fly   684 FQTPSRLFFVIEFVRGGDLMYHMQRQRRLPEEHARFYAAEISLALNFLHEKGIIYRDLKLDNVLL 748
            |||..|||||:|:|.|||||:.:||.|:..|..:||||||::.||.|||:.|:|||||||||:||
Zfish   483 FQTKDRLFFVMEYVNGGDLMFQIQRSRKFDEARSRFYAAEVTSALMFLHQHGVIYRDLKLDNILL 547

  Fly   749 DHEGHIKLTDYGMCKEGIRPGDTTSTFCGTPNYIAPEILRGEDYGFSVDWWALGVLLYEMLAGRS 813
            |.|||.||.|:|||||||..|.||:||||||:|||||||:..:||.||||||||||:|||:||:.
Zfish   548 DAEGHCKLADFGMCKEGILNGVTTTTFCGTPDYIAPEILQELEYGPSVDWWALGVLMYEMMAGQP 612

  Fly   814 PFDLAGASENPDQNTEDYLFQVILEKTIRIPRSLSVRAASVLKGFLNKNPADRLGCHRESAFMDI 878
            ||         :.:.||.||:.||...:..|..||..|.|:||.|:.|||:.||||.......:.
Zfish   613 PF---------EADNEDDLFESILHDDVLYPVWLSKEAVSILKAFMTKNPSKRLGCVVTQGLEEA 668

  Fly   879 VS-HPFFKNMDWELLERKQVTPPFKPRLDSDRDLANFPPEFTGEAVQLTPDDDHVIDNIDQSEFE 942
            :. ||||:.:||..||::::.||||||:.:.||:.||..:||.|...|||.||.:|..|:|.||:
Zfish   669 IKVHPFFREIDWVQLEQRRIKPPFKPRIKTKRDVNNFDQDFTREDPVLTPVDDAIIKQINQEEFK 733

  Fly   943 GFEY 946
            ||.|
Zfish   734 GFSY 737

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aPKC	NP_001260984.1	C1_1	498..550	CDD:278556	22/58 (38%)
		S_TKc	616..884	CDD:214567	143/268 (53%)
		STKc_aPKC	620..947	CDD:270740	173/328 (53%)
prkcea	XP_005156350.1	C2_PKC_epsilon	3..135	CDD:175981	7/33 (21%)
		C1_1	173..223	CDD:278556	21/49 (43%)
		C1_1	247..299	CDD:278556	9/51 (18%)
		S_TKc	415..675	CDD:214567	143/268 (53%)
		STKc_nPKC_epsilon	419..739	CDD:270743	173/328 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222529at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920