DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment NEO1 and fra

DIOPT Version :9

Sequence 1:	XP_005254465.1	Gene:	NEO1 / 4756	HGNCID:	7754	Length:	1481	Species:	Homo sapiens
Sequence 2:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster

Alignment Length:	1664	Identity:	520/1664 - (31%)
Similarity:	761/1664 - (45%)	Gaps:	331/1664 - (19%)

- Green bases have known domain annotations that are detailed below.

Human     1 MAAERGARRLLSTPSFWLY--CLL--LLGRRAPGAAAARSGSAPQSPGASIRTFTPFYFLVEPVD 61
            :...|.:|.|.:    ||.  ||:  |:|          |..|.|:          ..|.:||.|
  Fly     3 ITTNRSSRTLWN----WLLSSCLIFQLIG----------SSLASQA----------LSFTLEPQD 43

Human    62 TLSVRGSSVILNCSAYSE------------PSPKIEWK-KDGTFLNLVSDDRRQLLPDGSLFISN 113
            .:...|.||:|.|:..:.            .|..|.|: .||..|.:|.|..|..|.:|||:||:
  Fly    44 AVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISS 108

Human   114 VVHSKHNKPDEGYYQCVATVESLGTIISRTAKLIVAGLPRFTSQPEPSSVYAGNNAILNC---EV 175
            |   :.|:...|.|||:.|.|.:|:|:||.|.:.:...|........:.:..|..|...|   |.
  Fly   109 V---EENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEA 170

Human   176 N--ADLVPFVRWEQNRQPLLLDD-RVIKLPSGMLVISNATEGDGGLYRCVVESGGPPKYSDEVEL 237
            |  ..:...|:|.::..||.||. |::.||:|.|.|......|.|.|:|.|.||...:.|.:..|
  Fly   171 NWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNL 235

Human   238 KVL--PDPEVISDLV--FLKQPSPLVRVIGQDVVLPCVASGLPTPTIKWMKNEEALD-TESSERL 297
            .:.  .||...:.:.  ||..|||.....|..|.|.|||:|:|.|.|||::|...|| .:...|.
  Fly   236 NIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRF 300

Human   298 VLLAGGSLEISDVTEDDAGTYFCIADNGNETIEAQAELTVQAQPEFLKQPTNIYAHESMDIVFEC 362
            .::..|||:||...:.|:|.|.|.|.|..::::|||.:.||..|:|:|.|.:..|||..:...:|
  Fly   301 SIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKC 365

Human   363 EVTGKPTPTVKWVKNGDMVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQAGAQLII 427
            ::.|||.|.::|:||||::.|:||.::|..|||::|||:.||.|.:||:..|..|:..|.|:|.:
  Fly   366 DIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRV 430

Human   428 LEHDVAI---------------------------------------------------------- 434
            :...|.|
  Fly   431 VPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTR 495

Human   435 --------------------------PTLP----------------------------------- 438
                                      ..||
  Fly   496 LRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDA 560

Human   439 ---------------------PTSLTSATTDHLAPATTGP---------LPSAPRDVVASLVSTR 473
                                 |.|..|...|...|...|.         |||.|||:||.:|.:|
  Fly   561 HKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSR 625

Human   474 FIKLTWRTPASDPHGDNLTYSVFYTKEGIARERVENTSHPGEMQVTIQNLMPATVYIFRVMAQNK 538
            |:.|:|..|..:. ||.:.|:|:|......||:...|....:.||.||:|:|...|.|||.|...
  Fly   626 FVTLSWVEPLQNA-GDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTN 689

Human   539 HGSGESSAPLRVETQPEVQLPGPAPNLRAYAASPTSITVTWETPVSGNGEIQNYKLYYMEKGTDK 603
            .|||.|||||.|.|||||.:.||..|...||.|...|.|.||.|...||||..|::||.|..:..
  Fly   690 FGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGA 754

Human   604 EQDVDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTPDVAVRTLSDVPSAAPQNLSLEVRNSK 668
            :...|.::....:..|:.:|:|...||.:|::|.|.|:.::.|:|.|..||..|.|::|||.:|.
  Fly   755 DLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSS 819

Human   669 SIMIHWQPPAPATQNGQITGYKIRYRKASRKSDVTETLVSGTQLSQLIEGLDRGTEYNFRVAALT 733
            ||.:||:|||...:|||||||||||||......|..|..:.....  :..|||..||..::||:|
  Fly   820 SITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFE--LSNLDRNAEYQVKIAAMT 882

Human   734 INGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRGYAIGYGIG 798
            :||:||.|:|..|.|.|:|||||:||..|..:.:.|...:|.:.|.||::..|.:|.|.:|:|.|
  Fly   883 VNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRG 947

Human   799 SPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSEVDLFVINA 863
            .|...||::...:||:.::||:.:..||::|:|.|..|:|.|:|::..||..
  Fly   948 IPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDE------------- 999

Human   864 PYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIPANTKYKNA 928
              .||..|||:..|||::|..:|..:|.:.|.|..|.|:|.:||:|:|||.:  .|..:.:|:..
  Fly  1000 --EPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYH 1060

Human   929 NATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFELVPTSPPKDVTVVSKEGKPKTI 993
            |.|.|:.::..|:|||.|||:|.|.||||.|:|||:...:|::.||.:||::|||...|..|.|:
  Fly  1061 NTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTV 1125

Human   994 IVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYFKIQARNSK 1058
            ||.|.||....|:||||.|||:||......||.:|...|......:..|...|.||||:|||.:|
  Fly  1126 IVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTK 1190

Human  1059 GM--GPMSEAVQFRTPKADSSDKMPNDQASGSGGKGSRLPDLGSDYKPPMSGSNSPHGSPTSPLD 1121
            |.  .|.|..|.:.|..|.:..: |:..|.|                                :|
  Fly  1191 GANNAPFSALVSYTTSAAVTMQE-PDTIAKG--------------------------------ID 1222

Human  1122 SNMLL-VIIVSVGVITIVVVVIIAVFCTRRTTS---HQKKKRAACKSVNGSHKYKGNSKDV-KPP 1181
            :..|| :||.:..|:.:||::.:.:.|.|:..|   |.||            .|:.|:..| |||
  Fly  1223 NEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK------------SYQKNNVGVPKPP 1275

Human  1182 DLWIHHERLELKPIDKSPDPNPIMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHESEDSMST 1246
            ||||||:::|||.|||.     :.|.||:                             ..|..|:
  Fly  1276 DLWIHHDQMELKNIDKG-----LHTVTPV-----------------------------CSDGASS 1306

Human  1247 LAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPGSPWPIGTSM 1311
            .......|..:...::.:.|.|   .|..:|||.  ..:....:.:.....:..|..|   .|..
  Fly  1307 SGALTLPRSVVHSEYEVETPVP---GHVTNSLDK--RSYVPGYMTTSMNGTMERPQYP---RTQY 1363

Human  1312 SLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYL-ASSQEEDSGQSLPTAHVRP 1375
            |..:|::.|.....:..:.|.|.|:|.....:|  |.|...:::. |.:....:|........:.
  Fly  1364 SHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEH--PYGGYDANFCNAGNAAAGNGCVSTIESSKR 1426

Human  1376 SHPLKSFAVPAIPPPGPPTYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMPVVVPSAP 1440
            .||||||:||..||.|..|  |....||.::.:..|...:...:.|..|..|.:.. ..||.|..
  Fly  1427 GHPLKSFSVPGPPPTGGAT--PVTKHTPAVTIRPQNQSPYKKPSFSAATPNRLQGG-GSVVHSTD 1488

Human  1441 EVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAIT 1479
            |:|.    |..|.|:   :||.:|||:||||||||:|||
  Fly  1489 EIQR----LAPSTST---EELNQEMANLEGLMKDLSAIT 1520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEO1	XP_005254465.1	Ig1_Neogenin	54..148	CDD:143199	37/106 (35%)
		IG_like	59..148	CDD:214653	35/101 (35%)
		Ig_2	157..239	CDD:290606	26/87 (30%)
		IG_like	158..239	CDD:214653	26/86 (30%)
		I-set	250..337	CDD:254352	35/89 (39%)
		IGc2	262..326	CDD:197706	27/64 (42%)
		I-set	341..427	CDD:254352	37/85 (44%)
		Ig4_Neogenin	357..427	CDD:212460	30/69 (43%)
		FN3	459..552	CDD:238020	41/92 (45%)
		FN3	559..648	CDD:238020	30/88 (34%)
		FN3	656..748	CDD:238020	43/91 (47%)
		FN3	759..838	CDD:214495	26/78 (33%)
		FN3	876..969	CDD:238020	39/92 (42%)
		FN3	976..1071	CDD:238020	41/96 (43%)
		Neogenin_C	1178..1481	CDD:284094	86/304 (28%)
fra	NP_523716.2	Ig	36..140	CDD:299845	37/106 (35%)
		Ig	<180..222	CDD:299845	16/41 (39%)
		IG_like	257..340	CDD:214653	33/82 (40%)
		IGc2	264..327	CDD:197706	26/62 (42%)
		I-set	344..430	CDD:254352	37/85 (44%)
		Ig	363..428	CDD:299845	29/64 (45%)
		FN3	611..703	CDD:238020	41/92 (45%)
		FN3	711..799	CDD:238020	30/87 (34%)
		FN3	806..897	CDD:238020	43/92 (47%)
		FN3	908..989	CDD:238020	27/80 (34%)
		FN3	1011..1097	CDD:238020	39/87 (45%)
		FN3	1109..1205	CDD:238020	41/95 (43%)
		Neogenin_C	1273..1521	CDD:284094	85/302 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1870
Inparanoid	1	1.050	711	1.000	Inparanoid score	I649
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46607
OrthoDB	1	1.010	-	-		D118438at33208
OrthoFinder	1	1.000	-	-		FOG0002773
OrthoInspector	1	1.000	-	-		otm41079
orthoMCL	1	0.900	-	-		OOG6_105369
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3265
SonicParanoid	1	1.000	-	-		X1863
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	13.010