DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment NELL2 and crb

DIOPT Version :9

Sequence 1:XP_016874830.1 Gene:NELL2 / 4753 HGNCID:7751 Length:871 Species:Homo sapiens
Sequence 2:NP_001247284.1 Gene:crb / 42896 FlyBaseID:FBgn0259685 Length:2253 Species:Drosophila melanogaster


Alignment Length:1183 Identity:226/1183 - (19%)
Similarity:336/1183 - (28%) Gaps:540/1183 - (45%)


- Green bases have known domain annotations that are detailed below.


Human    82 VLTELELGESTTGVRQVPGLHNGTKAFLFQDTP-----------RSIKASTATAEQFFQKLRNKH 135
            :|..|....::..|.......||: .:|...||           ||.:.....|:|:     ||:
  Fly    73 ILIYLATDVASVAVPTKEAYFNGS-TYLRLTTPMPIWDHSAISFRSCRGGEILAQQY-----NKN 131

Human   136 EFTILVTLKQTHLNSGVILSIHHLDHRYLELESSGHRNEVRLHYRSGSHRPHTEV---FPYILAD 197
            ...|.|      ||.            :|::..:|          ...|.|:..:   .||.|.|
  Fly   132 SIVISV------LND------------FLQISLAG----------PAVHGPNNRLDVKLPYQLLD 168

Human   198 DKWHKLSLAISASHLILHID------CNKIY------ERVVEKPSTDLPLGTTFWLGQRNNAHGY 250
            ::||.|.......:|.||:|      .|..|      .:.:......|.||.:            
  Fly   169 NRWHTLQFKYEYGNLYLHVDRAASIFANSTYNSQFLTNQDIGYKDAILILGNS------------ 221

Human   251 FKGIMQD-----------VQLLVMPQGFIAQCPDLNRMFVIPACPTCNDFHGLVQKIMELQDILA 304
            |.|.:.|           ||.:|     ...||      :.|.  .|:| |.|            
  Fly   222 FSGCLLDGPGLQFVNNSTVQNVV-----FGHCP------LTPG--PCSD-HDL------------ 260

Human   305 KTSAKLSRAEQRMNRLDQCYC-ERTCTMKGTTYREFESWIDGC------KNCTCLNGTIQCETLI 362
                        ..||...:| ...|...||.....|.:...|      |||...||: .|....
  Fly   261 ------------FTRLPDNFCLNDPCMGHGTCSSSPEGYECRCTARYSGKNCQKDNGS-PCAKNP 312

Human   363 CPNPDCPLKSALAYVDGKC-C------KECKS------ICQFQGRTYFEGERNTVYSSSGVCVLY 414
            |.|....|:::..  |.:| |      :.|::      :||           .....::|.||  
  Fly   313 CENGGSCLENSRG--DYQCFCDPNHSGQHCETEVNIHPLCQ-----------TNPCLNNGACV-- 362

Human   415 ECKDQTMKLVESSGCPALDCPESHQITLSHSCCKVCKGYDFCSERHNCMENSICRNLNDRAVCSC 479
                    ::..||....:||:.:    :.:.|:|  ..|.|:.: .|..|..|.:..:...|.|
  Fly   363 --------VIGGSGALTCECPKGY----AGARCEV--DTDECASQ-PCQNNGSCIDRINGFSCDC 412

Human   480 R-DGFRALREDNAYCE-DIDECAE------GRHY-----------------------------CR 507
            . .|:     ..|:|: ::|||.:      ||.:                             |.
  Fly   413 SGTGY-----TGAFCQTNVDECDKNPCLNGGRCFDTYGWYTCQCLDGWGGEICDRPMTCQTQQCL 472

Human   508 ENTMCVNTPGSFMCICK---TGYIRIDDYSCTEH----DECITN--------------------- 544
            ....|::.|..|.|:|.   ||.:.....||.:.    .||:..                     
  Fly   473 NGGTCLDKPIGFQCLCPPEYTGELCQIAPSCAQQCPIDSECVGGKCVCKPGSSGPIGHCLPTTTT 537

Human   545 ----------------------------------------------------------------- 544
                                                                             
  Fly   538 PTPEQEPTTTPRTTPNPNPAIPNTLTTTTKIPPITTSRTLVGTTTGSRRPPQQPLQSPTQRSASL 602

Human   545 ----QHNCDENALCFNTVGGHNCVCKPGYTG-----------------------------NGTTC 576
                |.||.....|....|.::|:|..||||                             ||.||
  Fly   603 NACPQENCLNGGTCLGYSGNYSCICASGYTGYNCQTSTGDGASALALTPINCNATNGKCLNGGTC 667

Human   577 K-----AFCKDG-------------------------------------------CRNGGACI-- 591
            .     .:|..|                                           |:|||.|:  
  Fly   668 SMNGTHCYCAVGYSGDRCEKAENCSPLNCQEPMVCVQNQCLCPENKVCNQCATQPCQNGGECVDL 732

Human   592 --AANVCACPQGFTGPSCETDIDE-----------------------CSDGF--VQCDS------ 623
              ....|.|.:|:||.:|..|:||                       |:.||  |.|||      
  Fly   733 PNGDYECKCTRGWTGRTCGNDVDECTLHPKICGNGICKNEKGSYKCYCTPGFTGVHCDSDVDECL 797

Human   624 ------RANCINLPGWYHCECRDGYHDNGMFSPSGESCE-DIDECGTGRHSCANDTICFNLDGGY 681
                  .|.|.|....|.|.|:.||        .||:|| ||||||:  :.|:|.:.|.:....:
  Fly   798 SFPCLNGATCHNKINAYECVCQPGY--------EGENCEVDIDECGS--NPCSNGSTCIDRINNF 852

Human   682 DCRCPHG----------KNCTGD-CIHDGK--------------VKHNGQIWVLENDRCSVCSCQ 721
            .|.|..|          .:|.|| |::.|:              ..:.|:...|..|.|....|.
  Fly   853 TCNCIPGMTGRICDIDIDDCVGDPCLNGGQCIDQLGGFRCDCSGTGYEGENCELNIDECLSNPCT 917

Human   722 NGFVMCRRM---VCDCENPTVDLFC---CPECDP---RLSSQCLHQNGETLYN-----------S 766
            ||.....|:   .|||.|......|   ..||:.   :.:..||.::..|||.           |
  Fly   918 NGAKCLDRVKDYFCDCHNGYKGKNCEQDINECESNPCQYNGNCLERSNITLYQMSRITDLPKVFS 982

Human   767 GDTWVQNCQ--QCRCLQGEV---------DCWPLPC------------------PDVE---CEFS 799
            .....:|..  :|.|:.|.:         :|...||                  |..|   ||.:
  Fly   983 QPFSFENASGYECVCVPGIIGKNCEININECDSNPCSKHGNCNDGIGTYTCECEPGFEGTHCEIN 1047

Human   800 ILPENECCPRCVTDPCQADTIRNDITKTCLDEMN------VVRFTGSSWIKHGTECTLCQCKNGH 858
            |    :.|.|  .:|||..        ||.|:::      ...:.|.:.......|....|.||.
  Fly  1048 I----DECDR--YNPCQRG--------TCYDQIDDYDCDCDANYGGKNCSVLLKGCDQNPCLNGG 1098

Human   859 ICCSVDPQCLQEL 871
            .|.   |..:.|:
  Fly  1099 ACL---PYLINEV 1108

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NELL2XP_016874830.1 None
crbNP_001247284.1 LamG 91..228 CDD:238058 37/182 (20%)
EGF_CA 386..423 CDD:238011 9/42 (21%)
EGF_CA 425..460 CDD:238011 5/34 (15%)
EGF 466..495 CDD:278437 7/28 (25%)
EGF 605..633 CDD:278437 9/27 (33%)
EGF_CA 716..750 CDD:238011 10/33 (30%)
EGF_CA 753..789 CDD:238011 7/35 (20%)
EGF_CA 792..828 CDD:238011 10/43 (23%)
EGF_CA 830..865 CDD:238011 12/36 (33%)
EGF_CA 868..905 CDD:238011 6/36 (17%)
EGF_CA 907..943 CDD:238011 10/35 (29%)
EGF_CA 1009..1045 CDD:238011 5/35 (14%)
EGF_CA 1047..1082 CDD:238011 10/48 (21%)
Laminin_G_1 1155..1290 CDD:278483
EGF 1316..1346 CDD:278437
Laminin_G_1 1388..1550 CDD:278483
EGF_CA <1593..1622 CDD:238011
Laminin_G_2 1692..1828 CDD:280389
EGF_CA 1901..1937 CDD:238011
EGF_CA 1939..1974 CDD:238011
EGF_CA 2057..2094 CDD:238011
EGF_CA 2096..2133 CDD:238011
EGF_CA 2137..2175 CDD:238011
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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