DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEK3 and niki

DIOPT Version :9

Sequence 1:	NP_002489.1	Gene:	NEK3 / 4752	HGNCID:	7746	Length:	506	Species:	Homo sapiens
Sequence 2:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	252	Identity:	102/252 - (40%)
Similarity:	157/252 - (62%)	Gaps:	3/252 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     3 DYMVLRMIGEGSFGRALLVQHESSNQMFAMKEIRLPK-SFSNTQNSRKEAVLLAKMKHPNIVAFK 66
            :|..:|::|:||||.|:|.:.:|.......|:|.|.: |......:..|..:.:|:.|||||::.
  Fly   104 NYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVSYL 168

Human    67 ESFEAEGHLYIVMEYCDGGDLMQKIKQQKGKL-FPEDMILNWFTQMCLGVNHIHKKRVLHRDIKS 130
            .||..:..|.|.|||.|||.|.|.|.:::||| |||..|:..|.|:...:|::|.:.:||||:|:
  Fly   169 GSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDLKT 233

Human   131 KNIFLTQNGKVKLGDFGSARLLSNPMAFACTYVGTPYYVPPEIWENLPYNNKSDIWSLGCILYEL 195
            .|:||.:.|.||:||||.:::: |....|.|.:|||||..||:.|...|:||||||:|||||.|:
  Fly   234 ANVFLNRRGIVKIGDFGISKIM-NTKIHAQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILGEM 297

Human   196 CTLKHPFQANSWKNLILKVCQGCISPLPSHYSYELQFLVKQMFKRNPSHRPSATTLL 252
            |.||..|.|::...|:.|:..|..:|:||.|:..|:.|:..:.:.....||:|:.:|
  Fly   298 CCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVL 354

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK3	NP_002489.1	Interaction with VAV2. /evidence=ECO:0000269\|PubMed:15618286	1..285		102/252 (40%)
		STKc_Nek3	3..257	CDD:173759	102/252 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..325
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	441..490
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	102/252 (40%)
		S_TKc	105..354	CDD:214567	101/249 (41%)
		ATS1	445..747	CDD:227511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820