Protein Alignment NEK2 and Nek2

DIOPT Version :10

• Sequence 1: NP_002488.1
• Gene: NEK2 / 4751
• HGNCID: 7745
• Length: 445
• Species: Homo sapiens
• Sequence 2: NP_446143.1
• Gene: Nek2 / 114482
• RGDID: 619792
• Length: 443
• Species: Rattus norvegicus
• Alignment Length: 445
• Identity: 398/445 - (89%)
• Similarity: 423/445 - (95%)
• Gaps: 2/445 - (0%)

Human     1 MPSRAEDYEVLYTIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEAEKQMLVSEVNLLRELKHP 65
            ||||.||||||::|||||||||||||||||||||||||||||||||.||||||||||||||||||
  Rat     1 MPSRVEDYEVLHSIGTGSYGRCQKIRRKSDGKILVWKELDYGSMTEVEKQMLVSEVNLLRELKHP 65

Human    66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKERQYLDEEFVLRVMTQLTLALKECHRR 130
            ||||||||||||||||||||||||||||||||||||||:||||:|||||||||||||||||||||
  Rat    66 NIVRYYDRIIDRTNTTLYIVMEYCEGGDLASVITKGTKDRQYLEEEFVLRVMTQLTLALKECHRR 130

Human   131 SDGGHTVLHRDLKPANVFLDGKQNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQMNRMSYNE 195
            ||||||||||||||||||||.|.||||||||||||||||||||||||||||||||||::|:||||
  Rat   131 SDGGHTVLHRDLKPANVFLDSKHNVKLGDFGLARILNHDTSFAKTFVGTPYYMSPEQISRLSYNE 195

Human   196 KSDIWSLGCLLYELCALMPPFTAFSQKELAGKIREGKFRRIPYRYSDELNEIITRMLNLKDYHRP 260
            ||||||||||||||||||||||||:|||||||||||:||||||||||.||::|||||||||||||
  Rat   196 KSDIWSLGCLLYELCALMPPFTAFNQKELAGKIREGRFRRIPYRYSDGLNDLITRMLNLKDYHRP 260

Human   261 SVEEILENPLIADLVADEQRRNLERRGRQLGEPEKSQDSSPVLSELKLKEIQLQERERALKAREE 325
            |||||||:||||||||:|||||||||||:.|||.|.||||||||||||||.|||:|||||:|||:
  Rat   261 SVEEILESPLIADLVAEEQRRNLERRGRRSGEPSKLQDSSPVLSELKLKERQLQDRERALRARED 325

Human   326 RLEQKEQELCVRERLAEDKLARAENLLKNYSLLKERKFLSLASNPELLNLPSSVIKKKVHFSGES 390
            .|||||:|||:|||||||||||||:||||||||||.:.|.||...| |:||||.:||||||.|||
  Rat   326 SLEQKERELCIRERLAEDKLARAESLLKNYSLLKEHRLLCLAGGSE-LDLPSSALKKKVHFHGES 389

Human   391 KENIMRSENSESQLTSKSKCKDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 445
            |||..||||||||| :||||:||||||||||||||||||||||||||||||||||
  Rat   390 KENTARSENSESQL-AKSKCRDLKKRLHAAQLRAQALSDIEKNYQLKSRQILGMR 443

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK2	NP_002488.1	STKc_Nek2	7..271	CDD:270857	247/263 (94%)
		Interaction with PCNT. /evidence=ECO:0000269|PubMed:20599736	264..445		149/180 (83%)
		Interaction with CEP85. /evidence=ECO:0000269|PubMed:26220856	301..445		118/143 (83%)
		Leucine-zipper	306..334		21/27 (78%)
		Necessary for interaction with MAD1L1. /evidence=ECO:0000269|PubMed:14978040	329..445		95/115 (83%)
		Required for microtubule binding and for localization to the centrosomes	333..370		29/36 (81%)
		Interaction with SAV1 and STK3/MST2. /evidence=ECO:0000269|PubMed:21076410	403..439		32/35 (91%)
Nek2	NP_446143.1	STKc_Nek2	7..271	CDD:270857	247/263 (94%)