Protein Alignment NEK1 and MKK2

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_015185.1
• Gene: MKK2 / 855963
• SGDID: S000006061
• Length: 506
• Species: Saccharomyces cerevisiae
• Alignment Length: 291
• Identity: 83/291 - (28%)
• Similarity: 150/291 - (51%)
• Gaps: 27/291 - (9%)

Human    10 IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQYRESF--EE 72
            :|||:.|.....:.....:.:.:|.||......:.:::..||:....:.|...||||...|  |:
Yeast   220 LGEGAGGSVAKCRLKNGKKVFALKTINTMNTDPEYQKQIFRELQFNKSFKSDYIVQYYGMFTDEQ 284

Human    73 NGSLYIVMDYCEGGDL---FKRINAQKGVLFQEDQILDWFVQICL-ALKHVHDRKILHRDIKSQN 133
            :.|:||.|:|..|..|   :|.:..:.|.:  .::::....:..| .|.::|:||::|||||.||
Yeast   285 SSSIYIAMEYMGGKSLEATYKNLLKRGGRI--SERVIGKIAESVLRGLSYLHERKVIHRDIKPQN 347

Human   134 IFLTKDGTVQLGDFGIA-RVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYELC 197
            |.|.:.|.::|.|||:: ..:||   ||.|..||.:|::||..:.:||:...|:|:||..|.|:.
Yeast   348 ILLNEKGEIKLCDFGVSGEAVNS---LAMTFTGTSFYMAPERIQGQPYSVTCDVWSLGLTLLEVA 409

Human   198 TLKHAFEAGSMK------NLVLKIISGS-----FPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNS 251
            ..:..||:..:.      .|:..|::.|     .|.:.:.:|...||.:....|::.|:|||...
Yeast   410 GGRFPFESDKITQNVAPIELLTMILTFSPQLKDEPELDISWSKTFRSFIDYCLKKDARERPSPRQ 474

Human   252 ILEKGFIAKRIEKFLSPQLIAEEFCLKTFSK 282
            :|:..:|..:::|    ::..|.|..|.:.|
Yeast   475 MLKHPWIVGQMKK----KVNMERFVKKCWEK 501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	77/265 (29%)
MKK2	NP_015185.1	PKc_Pek1_like	212..499	CDD:270793	82/287 (29%)