Protein Alignment NEK1 and MKK1

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_014874.1
• Gene: MKK1 / 854406
• SGDID: S000005757
• Length: 508
• Species: Saccharomyces cerevisiae
• Alignment Length: 297
• Identity: 86/297 - (28%)
• Similarity: 150/297 - (50%)
• Gaps: 40/297 - (13%)

Human     3 KYVRLQK-------IGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKH 60
            ||..|:.       :|||:.|.....|.....:.:.:|.||......:.:::..||:....:.:.
Yeast   213 KYANLKDRIETLGILGEGAGGSVSKCKLKNGSKIFALKVINTLNTDPEYQKQIFRELQFNRSFQS 277

Human    61 PNIVQYRESF--EENGSLYIVMDYCEGGDL---FKRINAQKGVLFQEDQILDWFVQICL-ALKHV 119
            ..||:|...|  :||.|:||.|:|..|..|   :|.:..:.|.:  .:::|....:..| .|.::
Yeast   278 EYIVRYYGMFTDDENSSIYIAMEYMGGRSLDAIYKNLLERGGRI--SEKVLGKIAEAVLRGLSYL 340

Human   120 HDRKILHRDIKSQNIFLTKDGTVQLGDFGIA-RVLNSTVELARTCIGTPYYLSPEICENKPYNNK 183
            |::|::|||||.|||.|.::|.|:|.|||:: ..:||   ||.|..||.:|::||..:.:||:..
Yeast   341 HEKKVIHRDIKPQNILLNENGQVKLCDFGVSGEAVNS---LATTFTGTSFYMAPERIQGQPYSVT 402

Human   184 SDIWALGCVLYELCTLKHAFEAGSMK--------NLVLKIIS-----GSFPPVSLHYSYDLRSLV 235
            ||:|:||..:.|:...|  |...|.|        .|::.|::     ...|..::.:|...:|.:
Yeast   403 SDVWSLGLTILEVANGK--FPCSSEKMAANIAPFELLMWILTFTPELKDEPESNIIWSPSFKSFI 465

Human   236 SQLFKRNPRDRPSVNSILE----KGFIAKRI--EKFL 266
            ....|::.|:|||...::.    ||.:.|.:  |||:
Yeast   466 DYCLKKDSRERPSPRQMINHPWIKGQMKKNVNMEKFV 502

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	82/285 (29%)
MKK1	NP_014874.1	Protein Kinases, catalytic domain	219..506	CDD:473864	83/291 (29%)