Protein Alignment NEK1 and STE7

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_010122.1
• Gene: STE7 / 851396
• SGDID: S000002318
• Length: 515
• Species: Saccharomyces cerevisiae
• Alignment Length: 315
• Identity: 85/315 - (26%)
• Similarity: 157/315 - (49%)
• Gaps: 47/315 - (14%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMK-HPNIV 64
            ::..|:|.|||.|:.|..:......|.:....|.|.:.:.:|....:..||::::.|:| |.||:
Yeast   188 LQDLVQLGKIGAGNSGTVVKALHVPDSKIVAKKTIPVEQNNSTIINQLVRELSIVKNVKPHENII 252

Human    65 QYRESFEE---NGSLYIVMDYCEGGDL------FKRINAQKGVLFQEDQILDWFVQICLA----- 115
            .:..::..   |..:.|:|:|.:.|.|      :||. .|:|.:..:.   .||.::.::
Yeast   253 TFYGAYYNQHINNEIIILMEYSDCGSLDKILSVYKRF-VQRGTVSSKK---TWFNELTISKIAYG 313

Human   116 ----LKHVHDR-KILHRDIKSQNIFLTKDGTVQLGDFGIA-RVLNSTVELARTCIGTPYYLSPEI 174
                |.|::.: ||:|||||..|:.:...|.::|.|||:: :::||   :|.|.:||..|:|||.
Yeast   314 VLNGLDHLYRQYKIIHRDIKPSNVLINSKGQIKLCDFGVSKKLINS---IADTFVGTSTYMSPER 375

Human   175 CENKPYNNKSDIWALGCVLYELCTLK-----HAFEAGSMKNLVLKIISGSFP--PVSLHYSYDLR 232
            .:...|:.|.|:|:||.::.||.|.:     |......:.:|:.:|::...|  |....||.::.
Yeast   376 IQGNVYSIKGDVWSLGLMIIELVTGEFPLGGHNDTPDGILDLLQRIVNEPSPRLPKDRIYSKEMT 440

Human   233 SLVSQLFKRNPRDRPSVNSILEKGFIAKRI-----EKFLSPQLIAEEFCLKTFSK 282
            ..|::...:|.|:|.|::.:|....|.|.:     :||       ..:|.|..||
Yeast   441 DFVNRCCIKNERERSSIHELLHHDLIMKYVSPSKDDKF-------RHWCRKIKSK 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	77/282 (27%)
STE7	NP_010122.1	PKc_Byr1_like	185..482	CDD:270792	81/307 (26%)