DRSC/TRiP Functional Genomics Resources

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Protein Alignment NEK1 and KIN3

DIOPT Version :10

Sequence 1:NP_001186326.1 Gene:NEK1 / 4750 HGNCID:7744 Length:1286 Species:Homo sapiens
Sequence 2:NP_009410.1 Gene:KIN3 / 851273 SGDID:S000000071 Length:435 Species:Saccharomyces cerevisiae


Alignment Length:408 Identity:122/408 - (29%)
Similarity:183/408 - (44%) Gaps:102/408 - (25%)


- Green bases have known domain annotations that are detailed below.


Human     3 KYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ-Y 66
            :|..|::||.||||....|......:..|.|:|....|:||||::...|.::|:.:||.|||: |
Yeast    24 EYQVLEEIGRGSFGSVRKVIHIPTKKLLVRKDIKYGHMNSKERQQLIAECSILSQLKHENIVEFY 88

Human    67 RESFEENGS-LYIVMDYCEGGDLFKRINAQKGVLFQEDQILD----W--FVQICLALKHVH---- 120
            ...|:|... ||:.|:||..|||.:.|...|    ||.:.:.    |  ..|:..||...|    
Yeast    89 NWDFDEQKEVLYLYMEYCSRGDLSQMIKHYK----QEHKYIPEKIVWGILAQLLTALYKCHYGVE 149

Human   121 --------DRK---------ILHRDIKSQNIFLTKDGT--------------------------- 141
                    ||.         ::|||:|..||||:.|.:                           
Yeast   150 LPTLTTIYDRMKPPVKGKNIVIHRDLKPGNIFLSYDDSDYNINEQVDGHEEVNSNYYRDHRVNSG 214

Human   142 ------------VQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLY 194
                        |:|||||:|:.|.::::.|.|.:|||||:|||:..::||:..||||:||||::
Yeast   215 KRGSPMDYSQVVVKLGDFGLAKSLETSIQFATTYVGTPYYMSPEVLMDQPYSPLSDIWSLGCVIF 279

Human   195 ELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILE----- 254
            |:|:|...|:|.:...|..||.:|....|..:||..|.:::..:...|.|.|||...:|:     
Yeast   280 EMCSLHPPFQAKNYLELQTKIKNGKCDTVPEYYSRGLNAIIHSMIDVNLRTRPSTFELLQDIQIR 344

Human   255 ---KGFIAKR--------------IEKFLSPQLIAEEFCLKTFSKFGSQPIP--AKRPASGQ--- 297
               |....:|              |||.|..|.|..|..|....:..:|.:.  |:...||:   
Yeast   345 TARKSLQLERFERKLLDYENELTNIEKILEKQAIEYERELSQLKEQFTQAVEERAREVISGKKVG 409

Human   298 ---NSISVMPAQKITKPA 312
               .||:....:|..|||
Yeast   410 KVPESINGYYGKKFAKPA 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
NEK1NP_001186326.1 STKc_Nek1 3..258 CDD:270858 103/330 (31%)
KIN3NP_009410.1 STKc_Nek2 24..343 CDD:270857 102/322 (32%)

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