Protein Alignment NEK1 and nek1

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: XP_009292952.1
• Gene: nek1 / 556002
• ZFINID: ZDB-GENE-040730-1
• Length: 1413
• Species: Danio rerio
• Alignment Length: 1482
• Identity: 715/1482 - (48%)
• Similarity: 898/1482 - (60%)
• Gaps: 265/1482 - (17%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
            |:||.||:|||||||||||||||..||||||||||.|||||:|||:|||:||||||||.||||||
Zfish     1 MDKYERLKKIGEGSFGKAILVKSRTDGRQYVIKEIGISRMSNKERQESRKEVAVLANMSHPNIVQ 65

Human    66 YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIK 130
            |:|||||:|.|||||||||||||||:||.|:|.||.|:|||||||||||||||||||||||||||
Zfish    66 YKESFEESGCLYIVMDYCEGGDLFKKINNQRGSLFPEEQILDWFVQICLALKHVHDRKILHRDIK 130

Human   131 SQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYE 195
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   131 SQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYE 195

Human   196 LCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 260
            :||||||||||:|||||||||.||:||||:|||.|||||::||||||||:||||::||:|.|:|:
Zfish   196 MCTLKHAFEAGNMKNLVLKIIRGSYPPVSIHYSPDLRSLLAQLFKRNPRERPSVSTILDKPFLAR 260

Human   261 RIEKFLSPQLIAEEFCLKTFSKFGSQP-------IPAKRPASGQNSISVMPAQKITKPAAKYGIP 318
            ||.|||||||||:||.    .....||       .||||||.|  .|.:..||||||||||||:|
Zfish   261 RIHKFLSPQLIAQEFS----HSIHLQPKMSVAHAAPAKRPAPG--PIPITSAQKITKPAAKYGVP 319

Human   319 LAYKKYGD--KKLHE--KKPLQKHKQA--HQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQ 377
            |..::..:  :|:.:  |||: |.|||  ....::||:..||.|:..||..||:|:|.:|:|:||
Zfish   320 LTVRRPSEVARKVPDAAKKPV-KLKQAPPPAAVQRRVSRVEEERRKHEEGVRKKRMEMMERERKQ 383

Human   378 KDQIISLMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGG------------ 430
            ::|:: |:||.||||.|:|:|.|||||||||||:|||:.|....:..|.|.||
Zfish   384 REQML-LLKAAQMKRFEREKLNRINRAREQGWRHVLSSSGGSSPERKFYGGGGGNGAPHSPGISP 447

Human   431 ------TIAPSS--FSSRGQYEHYHAIFDQMQQQRAED--NEAKWKREIYGRGLPERGILPGVRP 485
                  :..|||  ..||..|:..|...:::.:...:|  .|........||...:.|.|
Zfish   448 FPVPGPSPVPSSALAPSRAPYDRIHPSAEKLTKPTPKDGAGEGAVHAGDNGRTSSDSGTL----- 507

Human   486 GFPYGAAGHHHFPDADDIRKTLKRL----KAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQ 546
                  .||...|..:.:||..::.    :.:||...|||.:||||||::||||||||||||||.
Zfish   508 ------NGHACIPVKNGVRKEQRKTSLQNEQISKIDYANRFRGQLAVEKSKQVEEFLQRKREAML 566

Human   547 NKARAEGHMGILQNLAAMYGGRPSSSRGGKPR-NKEEEVYLARLRQIRLQNFNERQQIKAKLRGE 610
            ||.||||.:|..|||||::....:|||..:|| |||||.||.||||||||||||||||||:||||
Zfish   567 NKVRAEGQLGARQNLAAIFASWTNSSRCRRPRVNKEEEEYLTRLRQIRLQNFNERQQIKARLRGE 631

Human   611 KKEANHSEGQEGSEEADMRRKKIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEH-LVAKG 674
            |.:::.|:.||..|||.:|.||||:|||.:.|||||||||||:||:||||||||.||:| |||:|
Zfish   632 KYDSDGSDSQESCEEAVLRMKKIEALKAQSKARAAVLKEQLEKKRREAYEREKKAWEDHQLVARG 696

Human   675 VK---------SSDVSPPLGQHE-------TGGSPSKQQMRSVISVTSALKEVGVDSS--LTDTR 721
            ||         .|..:||....:       :..:||.:.....||:|:|||:||..||  .:..:
Zfish   697 VKVAVGPVGGTPSPAAPPTPPSDPTPQEAPSKATPSSRPSTPAISMTAALKDVGAISSGQSSPMK 761

Human   722 ETSEEMQKTNNAISSKREILRRLNENLKAQEDEKGKQNLSDTFEINVHEDAKEH----------- 775
            |.|.::: :::..|.|:|||||||:.::..|            |::|.|.....
Zfish   762 EDSLKVE-SSDVQSDKKEILRRLNQKVQTTE------------EVSVKEPTPSSNQPCPDPQPVQ 813

Human   776 ----EKEKSVSSDRKKWEAGGQLVIPLDELTL--------------------------------- 803
                |:..|.::|||||||....::.:.|.||
Zfish   814 PSITEERPSTAADRKKWEAVAPPILSVAEQTLEETCATLAVSQVASPETNTPSCGDRKKWQTDGV 878

Human   804 -----------DTSFST----TERHTVGEVIKLG--PNGSPRRAWGKSPTDSVLKILGEAELQLQ 851
                       :|||.|    ||: ||||||.:.  .....|:|||:||...|||:|.|||||..
Zfish   879 PLLSVAQQTLEETSFRTAGQLTEK-TVGEVICMDAWQGEGLRKAWGQSPDSEVLKVLEEAELQSF 942

Human   852 TELLE-----NTTIRSEISP--------EGEKYKP-----LITGEKKVQCISHEINPSAIVDSPV 898
            |:.|:     :.|:...::|        |.::..|     ..|...|.:....|..|  |::
Zfish   943 TQRLDPASTCDQTLTESLNPIEESDATNEAKQVPPPEPCQPATDHDKQEVTCQETVP--IIE--- 1002

Human   899 ETKSPEFSEAS---PQMSLKLEGNLEEPDDLETEILQE-PSGTNKDESLPCTITDVWISEEKETK 959
            |.||.|..:.:   .:.|...|.::|..||:|:.:|.: |..|  .|..|..:...|   .|:|.
Zfish  1003 EVKSQELIQTTAEGTEKSHSAESDIEVVDDMESVVLDDVPQKT--AEPPPAEVIQAW---TKDTP 1062

Human   960 ETQSADRITIQENEVSEDGVSSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHL 1024
            |:..|:...||. |.:|      |.|..:.|.||..::|...|      :...|...:.|....|
Zfish  1063 ESLPAEGRVIQA-ECTE------VPQREEKHPEPPADESLFVK------LSSSPAHRRTVALAML 1114

Human  1025 NLVPQVQSVQCSPEE--SFAFRSHSHLPPK-NKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSK 1086
                   |.|.|.|:  |.|.||.|..|.: ::::::||||||||||||||||||||||||||||
Zfish  1115 -------SAQSSLEDSSSAASRSRSVSPLRSHRHEDALLIGLSTGLFDANNPKMLRTCSLPDLSK 1172

Human  1087 LFRTLMDVPTVGDVRQDNLEIDEIEDENIKEGPSDSEDIVFEETDTDLQELQASMEQLLREQPGE 1151
            :|..... |........||||:::||:  .:..|:.|| |:|  |.||:||:||||:||:||..|
Zfish  1173 VFSDATG-PEGAAAPDSNLEIEDLEDK--ADEQSEPED-VYE--DDDLRELRASMERLLQEQHSE 1231

Human  1152 EYSEEEES--------------------------------------VLKNSDVE--------PTA 1170
            :..:|||.                                      ...:.||.        |..
Zfish  1232 DDDDEEEDEGGGSNGSPADEEPAGLNGLASAGDDKRSPEEETFNGMAEDDEDVSHGEEEPGGPVT 1296

Human  1171 NGTDVADEDDNPSSESALNEEWHSDNSDGEIASECE-CDSVFNHLEELRLHLEQEMGFEKFFEVY 1234
            ||.:..|:::..|||:.|||||.||.|:.|...|.| .||:|:.||||||||||.||||.|.:.|
Zfish  1297 NGMEFEDDEEQNSSEAQLNEEWQSDGSEEEDDEELEQQDSIFSRLEELRLHLEQAMGFENFIQAY 1361

Human  1235 EKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQEDNDE 1286
            .|||||||||||||.:.|.:||||||.||||||.||||||||||||||||||
Zfish  1362 NKIKAIHEDEDENIAMGSSMVQNILGTEHQHLYPKILHLVMADGAYQEDNDE 1413

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	223/254 (88%)
nek1	XP_009292952.1	STKc_Nek1	3..258	CDD:270858	223/254 (88%)