DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEK1 and niki

DIOPT Version :9

Sequence 1:	NP_001186326.1	Gene:	NEK1 / 4750	HGNCID:	7744	Length:	1286	Species:	Homo sapiens
Sequence 2:	NP_651293.1	Gene:	niki / 42959	FlyBaseID:	FBgn0045980	Length:	841	Species:	Drosophila melanogaster

Alignment Length:	328	Identity:	127/328 - (38%)
Similarity:	193/328 - (58%)	Gaps:	36/328 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
            :..|.:::.:|:||||.|||.:...||.|.|.|:||:|.:|...|:.:..||.|.:.:.|||||.
  Fly   102 LANYEKVRVVGQGSFGIAILYRRKSDGHQIVFKQINLSELSPPGRDLAMNEVDVFSKLHHPNIVS 166

Human    66 YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVL-FQEDQILDWFVQICLALKHVHDRKILHRDI 129
            |..||.::.:|.|.|:|.:||.|.:.|..::|.| |.|..|:..|.||..|:.::|...|||||:
  Fly   167 YLGSFIKDNTLLIEMEYADGGTLAQIIAERQGKLHFPERYIIAVFEQISSAINYMHSENILHRDL 231

Human   130 KSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLY 194
            |:.|:||.:.|.|::|||||::::|:.:. |:|.:|||||.|||:||.|.|:||||||||||:|.
  Fly   232 KTANVFLNRRGIVKIGDFGISKIMNTKIH-AQTVLGTPYYFSPEMCEGKEYDNKSDIWALGCILG 295

Human   195 ELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSIL------ 253
            |:|.||..|.|.::..||.||::|::.||...|:..||||:|.|.:.....||:.:.:|
  Fly   296 EMCCLKKTFAASNLSELVTKIMAGNYTPVPSGYTSGLRSLMSNLLQVEAPRRPTASEVLVYWIPL 360

Human   254 -------EKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNSISV---MP-AQK 307
                   .||:..:  :....|               ||..:.|..||:..:::|:   :| ||.
  Fly   361 IFRSLGKNKGYSYE--DDVGGP---------------GSDQLTAPVPAAAYSNVSMELELPTAQT 408

Human   308 ITK 310
            .||
  Fly   409 ETK 411

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	115/268 (43%)
niki	NP_651293.1	STKc_Nek	104..359	CDD:270855	113/255 (44%)
		S_TKc	105..354	CDD:214567	112/249 (45%)
		ATS1	445..747	CDD:227511
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0589
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D132059at33208
OrthoFinder	1	1.000	-	-		FOG0000168
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820