Protein Alignment NEK1 and Nek2

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_572415.1
• Gene: Nek2 / 31696
• FlyBaseID: FBgn0029970
• Length: 735
• Species: Drosophila melanogaster
• Alignment Length: 772
• Identity: 189/772 - (24%)
• Similarity: 307/772 - (39%)
• Gaps: 234/772 - (30%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
            ::.|..|..:|.||||....|:....|..:..|.:|...:...:.:....|::||..::||||||
  Fly    16 LQDYEVLAVMGNGSFGTCYKVRDKSTGELFAWKGMNYDELDEAKCDALVSEISVLRQLQHPNIVQ 80

Human    66 YRESF--EENGSLYIVMDYCEGGDL---FKRINAQKGVLFQEDQILDWFVQICLALKHVHDR--- 122
            |....  .|..|:||||:.|.||||   .:|..:|: ..|:|..|.....|:|.||:..|::
  Fly    81 YYHHLVNREAKSVYIVMECCAGGDLAQIVQRARSQR-QRFEEPYIWRVLFQLCRALQVCHNKIPN 144

Human   123 -KILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDI 186
             .|||||||..||||...|..:|||||:||:|......|.:.:|||:|:|||:.:.:.|:.|||:
  Fly   145 GTILHRDIKPANIFLDAAGNAKLGDFGLARMLRRDQSFAASFVGTPHYMSPELVKGRKYDRKSDV 209

Human   187 WALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNS 251
            ||:||::||:|.|:..|...:...|..||..|.|..:...||.||:.:::.:...:...||.:..
  Fly   210 WAVGCLVYEMCALRPPFRGRAFDQLSEKIAQGEFSRIPAIYSTDLQEIIAFMLAVDHEQRPGIEV 274

Human   252 ILEKGFIAKRIE----KF-------------------------------LSPQLIAEEFCLKTFS 281
            |:....:.:.|.    ||                               ||..:..|::   :|:
  Fly   275 IIRHPLVVRNISELDGKFPILVDSGEDFYTLPSGARLFEDEEEDGVHPELSSTMFTEQY---SFN 336

Human   282 K-FGSQPI----------------PAKRPASGQNSISVMPAQKITKPAAKYGIPLAYKKYGDKKL 329
            : :|.:.:                .|||        .:.||:|:              :..|..|
  Fly   337 EGYGQRRLSVTGVFTPDLRSELFYSAKR--------KIFPAKKL--------------QLSDPSL 379

Human   330 HEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEFIEKEKKQK--------DQII---- 382
            :|.  :::.::|.   |::|...||||:..::..:||..|.:::.....        |:::
  Fly   380 YES--IRREERAE---ERQVELAEERRRKKDQEQQKRDQELLKEAPSSPRALTQNIFDEVLKTRL 439

Human   383 -------SLM--KAEQMKRQEKE------RLERINRARE----QGWRNVLSAGGSGEVKAPFLGS 428
                   ||:  |.|:::.:|:|      |::.:.|..:    |..::..|.      :.|
  Fly   440 HAIRAQESLLQQKLEELQTREQELQLAEQRVQTLERQMQEKLLQQEKHTCSC------RQP---- 494

Human   429 GGTIAPSSFSSRGQYEHYHAIFDQMQQQRAEDNEAKWK-------------REI----------Y 470
               |||.....:....|:...:..::........||..             |::          |
  Fly   495 ---IAPPIPPRKPAKSHHDDTYCTIELNETSPTVAKLNLATLPAPKSLNTLRKVTFKSPQKFVTY 556

Human   471 G-RGLPERGILPGVRP---GFPYGAAGHHHFPDADDI------RKTLKRL-------KAVSK--- 515
            | ..:|...:.|.|.|   |.|...:...:  |:.|.      ||::..|       ||.||
  Fly   557 GIENMPPPAVKPAVNPPPTGVPMQMSVSSN--DSGDSQASSTRRKSILSLFGLSRGSKATSKSLP 619

Human   516 ------QANANR-QKGQLAV---------------------ERAKQVEEFLQRKREAMQNKARAE 552
                  ||.|.| |:..|||                     |:.||..|.|     |..|.|..|
  Fly   620 SVNQVAQAAATRVQRPPLAVKPPITQEQPAEVPPVANLWTKEQKKQAFELL-----AAMNAAERE 679

Human   553 GHMGILQNLAAMYGGRPSSSRGGKPRNKEEEVYLARLRQ-IRLQNFN-ERQQIKAKL 607
                      |..||...|..||..|.        .||| :|.:|.. :|.:::..|
  Fly   680 ----------ASGGGVVGSGPGGARRQ--------HLRQSVRERNSTLQRNRMRRSL 718

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	95/263 (36%)
Nek2	NP_572415.1	STKc_Nek2	18..281	CDD:270857	95/263 (36%)