Protein Alignment NEK1 and fin1

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_593305.1
• Gene: fin1 / 2542237
• PomBaseID: SPAC19E9.02
• Length: 722
• Species: Schizosaccharomyces pombe
• Alignment Length: 739
• Identity: 178/739 - (24%)
• Similarity: 292/739 - (39%)
• Gaps: 165/739 - (22%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
            ||||..|:.||.||||:...|:..:||.....|||:...::.:|::....||.:|.|:|||||||
pombe     1 MEKYKILECIGHGSFGRIYKVQRLKDGALLAQKEIHFGNITRQEKQYIADEVNILRNLKHPNIVQ 65

Human    66 YRESFEENGSLYIV---MDYCEGGDLFKRINAQK--GVLFQEDQILDWFVQICLALKHVH----- 120
            |... |.|.|..::   |:||..|||...|...|  ...|.|.::|.:|.|:.|||...|
pombe    66 YCGE-ELNRSAQVINLYMEYCGHGDLANLIQRYKEEKKRFTEQEVLKFFTQLLLALYRCHYGENA 129

Human   121 --------------DRKILHRDIKSQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLS 171
                          .:.:||||||..||||.::.:|:|||||::::|::|....::.:|||||:|
pombe   130 PACDSQWPREIFHPKQSVLHRDIKPANIFLDENNSVKLGDFGLSKLLDNTRVFTQSYVGTPYYMS 194

Human   172 PEICENKPYNNKSDIWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVS 236
            |||..:.||:.|||:||||||::|:|.|.|.||..|...|...|..|:......|||.|:..|:.
pombe   195 PEIIRSSPYSAKSDVWALGCVIFEICMLTHPFEGRSYLELQRNICQGNLSCWDHHYSDDVFLLIR 259

Human   237 QLFKRNPRDRPSVNSILEKGFIAKRIEKFLSPQLIAEE-----------FCLKTFSKFGSQPIPA 290
            ...:.|...||:...:|....::....|..|.:::.|:           ..|:...:|..|.:.|
pombe   260 HCLEVNSDLRPTTYQLLRSPILSDIRSKLESERVVLEQSDLLHKKHQMLIQLENDLQFREQRLSA 324

Human   291 KRP------ASG---------------------------QNSISVMPAQKITKP----------A 312
            :..      ||.                           |..::.|...::|.|          .
pombe   325 RESELENVIASRLAQREEILRRELEKQLRDMDARYQRHMQTVVNSMQKMRVTSPVDHNEQPESST 389

Human   313 AKYGIPLAYKKYGDKKLH-EKKPLQKHKQAHQTPEKRVNTGEE-------RRKISEEA------- 362
            |:..:....:......|| .|..:.|..|....|...:.|.:.       |:::|..|
pombe   390 AEMFVDCTIEASQSPLLHIPKLGISKPLQTLSCPGFTLTTQQPILKRPTLRKELSSRALHTTATL 454

Human   363 ------ARKRRLEFIEKEKKQKDQIISLMKAEQMKRQEKERLERINRAREQGW------------ 409
                  |...|...|:|:    .||.||.:......|..:.:.::......|.
pombe   455 MKYRANASSLRTTPIDKD----GQITSLQQKNGTSNQVADCMNKLLHTSLDGKKLSPSELCNKFS 515

Human   410 -------RNVLSAGGSGEVKAPFLGSGGTIAPSS----FSSRGQYEH----YHAIFDQMQQQRAE 459
                   |.|.......:..|....||.::...|    ..|:..:.|    .....:::::....
pombe   516 DGEGLPNRKVSKLSVESDETAVSASSGESVPTDSTLTDTKSKSVFVHPPSPQSLYVEKLEKLNIR 580

Human   460 DNE----AKWKREIYGRGLPERGILPGVRPGFPYGAAGHHHFPDADDIRKTLKRLKAVSKQANAN 520
            .:|    :|..:.::|..||..        ..||...........:::....|.:|       .|
pombe   581 SDEVSKPSKASKTLHGYALPSL--------ASPYDVHAEEKIARENEMDGNFKTMK-------IN 630

Human   521 RQKGQLAVERAKQVEEFLQRKREAMQ-------NKAR--AEGHMGILQNLAAM---YGGRPSSSR 573
            :...:..:...|:::....:||..::       ||.|  |..:.|:....||.   |....|.:.
pombe   631 QHPDEYVLRTPKKIQLLEGQKRSPVKQLGRLGYNKLRRSAMDNAGLELRKAASTSNYTSLQSRTL 695

Human   574 GGKPRNKEEEV---YLARLRQIRL 594
            .|..|:.|||:   :|.::...|:
pombe   696 PGSWRDDEEEIPRPFLRKMLDARM 719

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	105/278 (38%)
fin1	NP_593305.1	STKc_Nek2	3..281	CDD:270857	105/278 (38%)