Protein Alignment NEK1 and nekl-2

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: NP_491914.1
• Gene: nekl-2 / 191199
• WormBaseID: WBGene00022631
• Length: 357
• Species: Caenorhabditis elegans
• Alignment Length: 322
• Identity: 121/322 - (37%)
• Similarity: 181/322 - (56%)
• Gaps: 23/322 - (7%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDG--RQYVIKEINISRMSSKEREESRREVAVLANMKHPNI 63
            |:.|.:::.:|.|:||...|.:...|.  ::.:||.||...|:.||....:.||.:|..::||.|
 Worm     1 MDNYEKVRVVGRGAFGVCWLCRGKNDASHQKVIIKLINTHGMTEKEENSIQSEVNLLKKVQHPLI 65

Human    64 VQYRESFEENGSLYIVMDYCEGGDLFKRINAQKGV-------LFQEDQILDWFVQICLALKHVHD 121
            :.|.:||..:..|.|||.|.|||.|.:.||.|:.:       .|.|..:||:|.||.:||.|:|.
 Worm    66 IGYIDSFIMDNQLGIVMQYAEGGTLERLINDQRAIKDSNMREYFPEKTVLDYFTQILIALNHMHQ 130

Human   122 RKILHRDIKSQNIFLTKDGTV-QLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSD 185
            :.|:|||:|.|||.:.:..|| :|.||||::.| .|...|.|.||||.||||||||::|||.|||
 Worm   131 KNIVHRDLKPQNILMNRRKTVLKLSDFGISKEL-GTKSAASTVIGTPNYLSPEICESRPYNQKSD 194

Human   186 IWALGCVLYELCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVN 250
            :|:||||||||..|:.||:..::..:|:||......|:..|.|.|::.||..|.|.:...||.|:
 Worm   195 MWSLGCVLYELLQLERAFDGENLPAIVMKITRSKQNPLGDHVSNDVKMLVENLLKTHTDKRPDVS 259

Human   251 SILEKGFIAKRIEKFLSPQLIAEEFCLKTFSKFGSQPIPAKRPASGQNS-ISVMPAQKITKP 311
            .:|.        :..:.|.||:....|   .:....|...::|::..:| :...|.|...:|
 Worm   260 QLLS--------DPLVLPYLISIHCDL---GRIEPPPTDKRKPSASLSSRLRTYPTQSTLRP 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	110/264 (42%)
nekl-2	NP_491914.1	STKc_Nek	3..267	CDD:270855	110/272 (40%)