Protein Alignment NEK1 and nek1

DIOPT Version :10

• Sequence 1: NP_001186326.1
• Gene: NEK1 / 4750
• HGNCID: 7744
• Length: 1286
• Species: Homo sapiens
• Sequence 2: XP_012827049.2
• Gene: nek1 / 100036653
• XenbaseID: XB-GENE-983162
• Length: 1320
• Species: Xenopus tropicalis
• Alignment Length: 1369
• Identity: 775/1369 - (56%)
• Similarity: 955/1369 - (69%)
• Gaps: 132/1369 - (9%)

Human     1 MEKYVRLQKIGEGSFGKAILVKSTEDGRQYVIKEINISRMSSKEREESRREVAVLANMKHPNIVQ 65
            |.||||:.|||||||||||||||.:||:|||||||.||:||:|||||||||||||||||||||||
 Frog     1 MNKYVRVSKIGEGSFGKAILVKSKDDGKQYVIKEIGISKMSNKEREESRREVAVLANMKHPNIVQ 65

Human    66 YRESFEENGSLYIVMDYCEGGDLFKRINAQKGVLFQEDQILDWFVQICLALKHVHDRKILHRDIK 130
            |:|||||:|.||||||||||||||||||:||||||.||||||||||:||||||||||||||||||
 Frog    66 YQESFEESGCLYIVMDYCEGGDLFKRINSQKGVLFSEDQILDWFVQLCLALKHVHDRKILHRDIK 130

Human   131 SQNIFLTKDGTVQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENKPYNNKSDIWALGCVLYE 195
            ||||||||.||:|||||||||||||||||||||||||||||||||||:|||||||||||||||||
 Frog   131 SQNIFLTKGGTIQLGDFGIARVLNSTVELARTCIGTPYYLSPEICENRPYNNKSDIWALGCVLYE 195

Human   196 LCTLKHAFEAGSMKNLVLKIISGSFPPVSLHYSYDLRSLVSQLFKRNPRDRPSVNSILEKGFIAK 260
            :||||||||||:|||||||||.||:||||:|||||||:|:|.||||||||||||||||||.||.:
 Frog   196 MCTLKHAFEAGNMKNLVLKIIRGSYPPVSVHYSYDLRNLLSMLFKRNPRDRPSVNSILEKPFIYR 260

Human   261 RIEKFLSPQLIAEEFCLKTF---SKFGSQPIPAKRPASGQNSISVMPAQKITKPAAKYGIPLAYK 322
            |||||||||.|||||.|..|   .|.|.|...||||...|...:..||.||||||||||:||..|
 Frog   261 RIEKFLSPQHIAEEFGLGAFVNHPKPGIQAAAAKRPTPAQVVPASPPAHKITKPAAKYGVPLTTK 325

Human   323 KYGD--KKLHEKKPLQKHKQAHQTPEKRVNTGEERRKISEEAARKRRLEF--IEKEKKQKDQIIS 383
            |..|  ||.|:|||..:|:||...|.|:||..:||||:.|:.|:|:|::.  :||||:|::| .:
 Frog   326 KSSDAAKKHHDKKPQIRHRQAPAVPLKKVNPVDERRKMFEDGAKKKRMDVRQLEKEKRQREQ-FN 389

Human   384 LMKAEQMKRQEKERLERINRAREQGWRNVLSAGGSGEVKAPFLGSGGTIAPSSFSSRGQYEHYHA 448
            |::||||:|.|||||||||||||||||||:|:||||::|||:.|.||.:||.....||.|||||:
 Frog   390 LLRAEQMRRLEKERLERINRAREQGWRNVISSGGSGDIKAPYFGGGGGVAPPQGMGRGPYEHYHS 454

Human   449 IFDQMQQQR-----AEDNEAKWKREI-----YGR--GLPERGILPGVRPGFPYGAAGHHHFPDAD 501
            ||||||||:     |.:.|.|.|.:|     |.|  ..||:...|          :.|..|||.|
 Frog   455 IFDQMQQQKENIKAAVEKEVKLKADIQNPDTYSRVPKHPEQENCP----------SAHSPFPDGD 509

Human   502 DIRKTLKRLKAVSKQANANRQKGQLAVERAKQVEEFLQRKREAMQNKARAEGHMGILQNLAAMYG 566
            .:|:.||||:.|..||..|:.:|.::.|:|:|||||||||.|||||||||||||..:.||||:.|
 Frog   510 AVRRELKRLQEVHNQAIGNKIQGHVSAEKARQVEEFLQRKHEAMQNKARAEGHMDAVHNLAAICG 574

Human   567 GRPSSSRGGKPRNKEEEVYLARLRQIRLQNFNERQQIKAKLRGEKKEANHSEGQEGSEEADMRRK 631
            |||:|:.|||.||:||:.|||||||||||||||||||||||||.|.:...::|:|.||:|::|||
 Frog   575 GRPNSAGGGKARNREEKEYLARLRQIRLQNFNERQQIKAKLRGAKGDEGDADGKESSEDAELRRK 639

Human   632 KIESLKAHANARAAVLKEQLERKRKEAYEREKKVWEEHLVAK-------GVKSSDVSPPLGQHET 689
            |||:|||.||||||::||:|||||:||.:|||::|||||..|       .|.::..||.....:.
 Frog   640 KIEALKAQANARAALIKEELERKRREADKREKRLWEEHLALKNPNVPCNAVGAAPGSPKHSHLDV 704

Human   690 GGSPSK-----QQMRSVISVTSALKEVGVDSSLTDTRETSEEMQKTNNAI-SSKREILRRLNENL 748
            ||||.:     :.....||:||||:.||.:......|:.:|..:.::.:: :.||:||||||.|:
 Frog   705 GGSPVRGHPHAKPSTPAISMTSALRNVGAEGEDAGLRDPTEGSKTSDTSVQNEKRQILRRLNNNM 769

Human   749 KAQEDEKGKQNLSDTFEINVHEDAKE-HEKEKSVSSDRKKWEAGGQLVIPLDELTL--DTSFSTT 810
            |:||:.:...  ..|.|..|..:.:| .|..:.::.|||||:|....||||.:|||  ||.| ..
 Frog   770 KSQEETEATN--PPTEENGVQTNGEEQQESGEPLAVDRKKWQAEPPPVIPLSQLTLVEDTVF-PL 831

Human   811 ERHTVGEVIKLGPNGSPRRAWGKSPTDSVLKILGEAELQLQTELLENTTIRSEISPEGEKYKPLI 875
            :..|||:||||......||.|||.|.|||||:||||:||||||||: .||..:...|.::.|.
 Frog   832 DNLTVGDVIKLDVEEPQRRLWGKDPGDSVLKVLGEAKLQLQTELLQ-VTIDEQCHEEADEEKE-- 893

Human   876 TGEKKVQCISHEINPSAIVD-----SPVETKS-----------PEFS-----EASPQM----SLK 915
                         ||....:     ||.|.|:           ||.|     |:|..:    .::
 Frog   894 -------------NPDMRDNLLNKVSPTEGKALILPNREGMPQPEVSPLVEEESSVPLVAFNQVE 945

Human   916 LEGNLEEPDDLETEILQEPSGTNKD-ESLPCTITDVWISEEKETKETQSADRITIQENEVSEDGV 979
            ::.| |:|:|||||||:|..|..|: ...|..:|:||..:.|:..|.|.|    ::..:.:||..
 Frog   946 IQSN-EDPEDLETEILEETEGKEKEGNECPVHVTNVWTEQTKQESEGQDA----VECEQPNEDAK 1005

Human   980 SSTVDQLSDIHIEPGTNDSQHSKCDVDKSVQPEPFFHKVVHSEHLNLVPQVQSVQCSPEESFAFR 1044
            ..|.....:.:||..:|         .:|..|:..|.||...:  ::|....|.|.|.::|...|
 Frog  1006 LDTECSEQEQNIENQSN---------RESSVPKALFEKVPLPQ--SVVTPTFSAQSSFDDSLPPR 1059

Human  1045 SHSHLPPKNKNKNSLLIGLSTGLFDANNPKMLRTCSLPDLSKLFRTLMDVPTVGDVR-QDNLEID 1108
            |.|..|.|.|.|::||||||.|||||||||||||||||||||||:|.:|.|||.||. ::.|||:
 Frog  1060 SRSASPTKTKGKSALLIGLSAGLFDANNPKMLRTCSLPDLSKLFKTFVDEPTVADVEGEEQLEIE 1124

Human  1109 EIEDENIKEGP-SDSEDIVFEETDTDLQELQASMEQLLREQPGEEYSEEEESVLKNSDVEPTA-- 1170
            :||||.:::.. |||||.:|.|||.||||:||||||||||:|.|:|..|:.:.|.:   ||.|
 Frog  1125 DIEDEPVQDADHSDSEDTMFGETDRDLQEMQASMEQLLREEPTEDYCAEKATHLNS---EPPAGI 1186

Human  1171 ----------NGTDVADEDD-------NPSSESALNEEWHSDNSDGEIASEC-ECDSVFNHLEEL 1217
                      ||.:..:|:|       .||.||.:|||||||:|..:.|||| :.||:|.||||:
 Frog  1187 KEENIESAIINGAEEEEEEDEEEEDGNQPSGESVINEEWHSDDSSEDFASECDDGDSLFAHLEEM 1251

Human  1218 RLHLEQEMGFEKFFEVYEKIKAIHEDEDENIEICSKIVQNILGNEHQHLYAKILHLVMADGAYQE 1282
            |..||||:|||||.|||.|||||||||||||:.||.:|:||||.||||||.::|.||||||||||
 Frog  1252 RFKLEQEIGFEKFIEVYNKIKAIHEDEDENIDSCSTVVENILGCEHQHLYPRVLRLVMADGAYQE 1316

Human  1283 DNDE 1286
            ||||
 Frog  1317 DNDE 1320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEK1	NP_001186326.1	STKc_Nek1	3..258	CDD:270858	228/254 (90%)
nek1	XP_012827049.2	STKc_Nek1	3..258	CDD:270858	228/254 (90%)