| Sequence 1: | NP_006149.2 | Gene: | NEFL / 4747 | HGNCID: | 7739 | Length: | 543 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001034927.1 | Gene: | neflb / 664698 | ZFINID: | ZDB-GENE-060312-44 | Length: | 579 | Species: | Danio rerio |
| Alignment Length: | 578 | Identity: | 325/578 - (56%) |
|---|---|---|---|
| Similarity: | 408/578 - (70%) | Gaps: | 60/578 - (10%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1 MSSFSYEPYYSTSYKRRYVETPRVHISSVRS------GYSTARSAYSSYSAPVSSSLSVRRSYSS 59
Human 60 SSG-SLMPSLENLDLSQVAAISNDLKSIRTQEKAQLQDLNDRFASFIERVHELEQQNKVLEAELL 123
Human 124 VLRQKHSEPSRFRALYEQEIRDLRLAAEDATNEKQALQGEREGLEETLRNLQARYEEEVLSREDA 188
Human 189 EGRLMEARKGADEAALARAELEKRIDSLMDEISFLKKVHEEEIAELQAQIQY-AQISVEMDVTKP 252
Human 253 DLSAALKDIRAQYEKLAAKNMQNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTL 317
Human 318 EIEACRGMNEALEKQLQELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMAL 382
Human 383 DIEIAAYRKLLEGEETRLSFTSVGSITSGYSQS---SQVFGRSAYGGLQTS-----SYLMSTRSF 439
Human 440 PSYYTSHVQEEQIEVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEA---------EEEEAAEEE 495
Human 496 EAAKEESEEAKEE-----EEGGEGEEGEETKEAEEEEKKVEGA-----GEEQAAKKKD 543 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| NEFL | NP_006149.2 | Head | 2..92 | 35/96 (36%) | |
| Filament_head | 9..88 | CDD:309741 | 26/85 (31%) | ||
| Filament | 89..399 | CDD:306535 | 219/310 (71%) | ||
| Coil 1A | 93..124 | 24/30 (80%) | |||
| Linker 1 | 125..137 | 8/11 (73%) | |||
| Coil 1B | 138..234 | 63/95 (66%) | |||
| Linker 12 | 235..252 | 12/17 (71%) | |||
| Coil 2A | 253..271 | 13/17 (76%) | |||
| Linker 2 | 272..280 | 5/7 (71%) | |||
| Coil 2B | 281..396 | 80/114 (70%) | |||
| Epitope, recognized by IF-specific monoclonal antibody | 381..391 | 9/9 (100%) | |||
| Tail | 397..543 | 72/172 (42%) | |||
| Tail, subdomain A | 397..443 | 18/53 (34%) | |||
| Tail, subdomain B (acidic) | 444..543 | 53/117 (45%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 462..543 | 48/99 (48%) | |||
| neflb | NP_001034927.1 | Filament_head | 11..81 | CDD:282575 | 25/83 (30%) |
| Filament | 82..393 | CDD:278467 | 219/310 (71%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 1 | 0.930 | - | - | C194336678 | |
| Domainoid | 1 | 1.000 | 443 | 1.000 | Domainoid score | I3715 |
| eggNOG | 1 | 0.900 | - | - | E1_28N6C | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 1 | 1.000 | - | - | H4487 | |
| Inparanoid | 1 | 1.050 | 564 | 1.000 | Inparanoid score | I5696 |
| NCBI | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 1 | 1.010 | - | - | QHG39836 | |
| OrthoDB | 1 | 1.010 | - | - | D266274at7742 | |
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 1 | 1.000 | - | - | otm26976 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_115428 | |
| Panther | 1 | 1.100 | - | - | LDO | PTHR45652 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R8160 |
| SonicParanoid | 1 | 1.000 | - | - | X62 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| ZFIN | 1 | 1.500 | - | - | ||
| 16 | 16.340 | |||||