DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NELL1 and shf

DIOPT Version :9

Sequence 1:	NP_001275642.1	Gene:	NELL1 / 4745	HGNCID:	7750	Length:	838	Species:	Homo sapiens
Sequence 2:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster

Alignment Length:	241	Identity:	65/241 - (26%)
Similarity:	92/241 - (38%)	Gaps:	79/241 - (32%)

- Green bases have known domain annotations that are detailed below.

Human   507 ECGSGQHNCDENAICTNTVQGHSCTCKPGYVGNGTICR-AFCEEGCRYGGTCVAPNKCVCPSGFT 570
            ||..   .|.:|..|.   :.|.|.|..||.|.  .|. |||...|..||.|.||:.|.||.|:.
  Fly   286 ECSL---KCGKNGYCN---EHHICKCNVGYTGQ--YCETAFCFPQCLNGGNCTAPSVCTCPEGYQ 342

Human   571 GSHCEKDIDECSEGIIECHNHSRCVNLPGWYHCECRSGFHDDGTYSLSGESCIDIDECALRTHTC 635
            |:.||..|  |.:   :|.|..:|:...   .|:|..|::        |..| :..:|.:   .|
  Fly   343 GTQCEGGI--CKD---KCLNGGKCIQKD---KCQCSKGYY--------GLRC-EYSKCVI---PC 387

Human   636 WNDSACINLAGGFDCLCPSGPSCSGDCPHEGGLKHNGQVWTLKEDRC-------SVCSCKDGKIF 693
            .|:..||   |...|.||:|                     |:.|.|       |:|.|::|...
  Fly   388 KNEGRCI---GNNLCRCPNG---------------------LRGDHCEIGRKQRSICKCRNGTCV 428

Human   694 CRRTACDCQNPSADLFCCPECDTRVTSQCLDQNGHK---LYRSGDN 736
            ..: .|.| :|.   |....|           ||.|   ::|:.|:
  Fly   429 SHK-HCKC-HPG---FYGRHC-----------NGRKRRHVHRNDDS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NELL1	NP_001275642.1	TSPN	57..241	CDD:214560
		VWC	301..359	CDD:278520
		EGF_CA	462..>494	CDD:214542
		EGF_3	508..543	CDD:289699	10/34 (29%)
		EGF_CA	577..614	CDD:214542	8/36 (22%)
		EGF_CA	624..>655	CDD:284955	9/30 (30%)
		VWC	662..714	CDD:302663	11/58 (19%)
		VWC	729..777	CDD:302663	3/11 (27%)
shf	NP_001284963.1	WIF	137..258	CDD:280237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910