DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NEFH and krt5

DIOPT Version :9

Sequence 1:	NP_066554.2	Gene:	NEFH / 4744	HGNCID:	7737	Length:	1020	Species:	Homo sapiens
Sequence 2:	NP_571231.2	Gene:	krt5 / 797351	ZFINID:	ZDB-GENE-991110-23	Length:	566	Species:	Danio rerio

Alignment Length:	439	Identity:	139/439 - (31%)
Similarity:	221/439 - (50%)	Gaps:	48/439 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     5 GGADALLGAPFAPLHGGGSLHYALARKGGAGGT--RSAAGSSSGFHSWTRTSVSSVSASPSRFRG 67
            ||.....||     ..|||..|::...||.||:  ....||..||.|.......:.....|.: |
Zfish    54 GGGGGGFGA-----GSGGSFSYSMGGGGGGGGSGFGGGFGSGGGFGSGGGFGGGAGFGGGSAY-G 112

Human    68 AGAASSTDSLDTLSNGPEGC--MVAVATSRS-------------------EKEQLQALNDRFAGY 111
            .||....      ..||.|.  :.||..:::                   ||||::.||:|||.:
Zfish   113 GGAGFGG------GFGPGGVVPITAVTVNQNLLAPLNLEIDPNIQVVRTQEKEQIKTLNNRFASF 171

Human   112 IDKVRQLEAHNRSLEGEAAALRQQQAGRSAMGELYEREVREMRGAVLRLGAAR----GQLRLEQE 172
            |||||.||..|:.||.:.:.|::|...||.:..::|..:..:|..:..||..:    |:|: ..:
Zfish   172 IDKVRFLEQQNKVLETKWSLLQEQTTTRSNIDAMFEAYIANLRRQLDGLGNEKMKLEGELK-NMQ 235

Human   173 HLLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVDLQKKAQALQEECGYLRRHHQEE 237
            :|:||.   :.:.:||..:|...|.....|.:....|...:|:|:.|..:||:|..:||...:||
Zfish   236 NLVEDF---KNKYEDEINKRAAVENEFVLLKKDVDAAYMNKVELEAKVDSLQDEINFLRAIFEEE 297

Human   238 VGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSE 302
            :.||..||:.:...     .|..::...|:.:.:.|:|||.|..|.:|..::|.|::.:.:.:..
Zfish   298 LRELQSQIKDTSVV-----VEMDNSRNLDMDAIVAEVRAQYEDIANRSRAEAESWYKQKFEEMQS 357

Human   303 AAKVNTDAMRSAQEEITEYRRQLQARTTELEALKSTKDSLERQRSELEDRHQADIASYQEAIQQL 367
            :|....|.:|:.:.||.:..|.:.....|:||:|..:.:||.|.:|.|:|.:..:...:..|:.|
Zfish   358 SAGKYGDDLRNTKAEIADLNRMISRLQNEIEAVKGQRANLEAQIAEAEERGELAVKDAKLRIKDL 422

Human   368 DAELRNTKWEMAAQLREYQDLLNVKMALDIEIAAYRKLLEGEECRIGFG 416
            :..|:..|.:||.|:||||:|:|||:|||||||.|||||||||.||..|
Zfish   423 EDALQRAKQDMARQVREYQELMNVKLALDIEIATYRKLLEGEESRIASG 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NEFH	NP_066554.2	Head	1..100		28/117 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	58..83		4/24 (17%)
		Filament	96..412	CDD:278467	110/338 (33%)
		Coil 1A	101..132		15/30 (50%)
		Linker 1	133..145		3/11 (27%)
		Coil 1B	146..244		27/101 (27%)
		Linker 12	245..266		2/20 (10%)
		Coil 2A	267..288		7/20 (35%)
		Linker 2	289..292		1/2 (50%)
		Coil 2B	293..413		47/119 (39%)
		BASP1	513..736	CDD:283191
krt5	NP_571231.2	Keratin_2_head	<129..153	CDD:292825	2/23 (9%)
krt5	NP_571231.2	Filament	156..467	CDD:278467	110/319 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_28N6C
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810