Protein Alignment NEFH and ifa-3

DIOPT Version :10

• Sequence 1: NP_066554.2
• Gene: NEFH / 4744
• HGNCID: 7737
• Length: 1020
• Species: Homo sapiens
• Sequence 2: NP_510649.3
• Gene: ifa-3 / 181699
• WormBaseID: WBGene00002051
• Length: 581
• Species: Caenorhabditis elegans
• Alignment Length: 545
• Identity: 136/545 - (24%)
• Similarity: 237/545 - (43%)
• Gaps: 108/545 - (19%)

Human    51 TRTSVSSVSASPSRFRGAGAASSTDSLDTLSNGPEGCMVAVATSRSEKEQLQALNDRFAGYIDKV 115
            |.|..|||::..|.: |.||||      |:.:..|          .||:::..||||.|.||.||
 Worm    42 TETHTSSVASGLSPY-GQGAAS------TIRDDRE----------REKKEITELNDRLASYIGKV 89

Human   116 RQLEAHNRSLEGEAAALRQQQAGRS--AMGELYEREV-----------REMRGAVLRLGAARGQL 167
            |.|.|.||.||.:...| |.:.|:|  ::..:||.|:           ::...|...:|..:.||
 Worm    90 RFLAAQNRKLEADLNVL-QSRFGKSTGSVKIMYEMEITTATNVVKETGKDHEEAEKEIGKIKDQL 153

Human   168 -----------------RLEQEHLLEDIAHVRQRL-----------DDEARQREEAEAAARALAR 204
                             ||:.:.||..::::...:           ::.||.::|.......|.|
 Worm   154 DELRKKFEEAQKGRAEDRLKIDELLVTLSNLEAEINLLKRRIALLEEEVARLKKENFRLTSELQR 218

Human   205 FAQEAE---AARVDLQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCD 266
            ...|.:   ..|:|.|.|...:.||..:::|..:.|:.:|..|      |.....:|.|:..|.:
 Worm   219 VRSELDQETLLRIDNQNKVTTILEEIDFMKRGFETELKDLQAQ------AARDTTSENREYFKNE 277

Human   267 VTSALREIRAQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYR---RQLQAR 328
            :.:::|:|||:.:.....:....|.|.::|:.      ::||...|. ..||...|   ::|.::
 Worm   278 LMNSIRDIRAEYDRFMAGNRNDLESWSQIRVQ------EINTQTNRQ-NAEINHKRDEVKRLHSQ 335

Human   329 TTELEA----LKSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLL 389
            .:||::    |.:....||:|..:|..:.:.|..||:.|:...||::|..:.|..|.|.|.|.||
 Worm   336 VSELKSKHAELAARNGLLEKQLEDLNYQLEDDQRSYEAALNDKDAQVRKLREECQALLVELQMLL 400

Human   390 NVKMALDIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIK------VKSEEKIKV-V 447
            :.|..||.|:..||::|||.....|..    .|.|.:.:..:::..:.      ||.|...:. .
 Worm   401 DTKQTLDGELKVYRRMLEGNSEENGLR----QLVEKVVRTSAINEEVDTETMRVVKGEHSSRTSY 461

Human   448 EKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGE---EEEAEGGEEETKSPPAEEA 509
            ::|.|..|.::|.:.|.:..  :.|...::      |||..|:   :.:.:|..|...:.|::..
 Worm   462 QRSAKGNVSIKEVSPEGKFV--ILENTHRD------KEEPLGDWKLKRKIDGKREIVFTFPSDYI 518

Human   510 ASPEKEAKSPVKEEAKSPAEAKSPE 534
            ..|.:    .||..|:....|..||
 Worm   519 LHPVQ----TVKIFARGNGVANPPE 539

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NEFH	NP_066554.2	Head	1..100		15/48 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..83		8/24 (33%)
		Filament	96..412	CDD:459643	97/366 (27%)
		Coil 1A	101..132		16/30 (53%)
		Linker 1	133..145		3/13 (23%)
		Coil 1B	146..244		26/139 (19%)
		Linker 12	245..266		4/20 (20%)
		Coil 2A	267..288		4/20 (20%)
		Linker 2	289..292		1/2 (50%)
		PTZ00121	<290..1014	CDD:173412	66/262 (25%)
		Coil 2B	293..413		38/126 (30%)
		Tail	414..1020		26/131 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	456..1020		17/82 (21%)
		30 X 6 AA repeats of K-S-P-[AEPV]-[EAK]-[AEVK]	525..826		3/10 (30%)
ifa-3	NP_510649.3	solA	<15..>86	CDD:236887	20/60 (33%)
		Filament	71..419	CDD:459643	95/361 (26%)
		LTD	464..570	CDD:460003	20/88 (23%)