DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Vps28 and VPS28

DIOPT Version :9

Sequence 1:	NP_001260796.1	Gene:	Vps28 / 47408	FlyBaseID:	FBgn0021814	Length:	210	Species:	Drosophila melanogaster
Sequence 2:	NP_898880.1	Gene:	VPS28 / 51160	HGNCID:	18178	Length:	233	Species:	Homo sapiens

Alignment Length:	175	Identity:	110/175 - (62%)
Similarity:	146/175 - (83%)	Gaps:	0/175 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 PELYEEVKLFRNAREREKYDNMADLYAIINTIQQLEKAYIRDCITPQEYTAACSKYLVQYKVAFK 70
            |||||||||::||||||||||||:|:|::.|:|.||||||:||::|.|||||||:.|||||.||:
Human    18 PELYEEVKLYKNAREREKYDNMAELFAVVKTMQALEKAYIKDCVSPSEYTAACSRLLVQYKAAFR 82

  Fly    71 QVQCDEFPSVETFVKKFRLDCPAALERIREDRPITIRDDKGNTSKCIAEIVSLFITIMDKLRLQI 135
            |||..|..|::.|.:|||||||.|:|||:|||||||:|||||.::|||::||||||:||||||:|
Human    83 QVQGSEISSIDEFCRKFRLDCPLAMERIKEDRPITIKDDKGNLNRCIADVVSLFITVMDKLRLEI 147

  Fly   136 NTMDALQPDVKDLADNMNRLSLIPEDFDAKLKVEKWLGSLNEMQA 180
            ..||.:|||:::|.:.|:|:|.:|.||:.:..|.:|..||...|:
Human   148 RAMDEIQPDLRELMETMHRMSHLPPDFEGRQTVSQWWVSLPARQS 192

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Vps28	NP_001260796.1	VPS28	27..207	CDD:397894	91/154 (59%)
VPS28	NP_898880.1	VPS28	39..187	CDD:309211	88/147 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160226
Domainoid	1	1.000	243	1.000	Domainoid score	I2223
eggNOG	1	0.900	-	-		E1_KOG3284
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69205
Inparanoid	1	1.050	287	1.000	Inparanoid score	I2847
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53660
OrthoDB	1	1.010	-	-		D1281819at2759
OrthoFinder	1	1.000	-	-		FOG0004132
OrthoInspector	1	1.000	-	-		oto91627
orthoMCL	1	0.900	-	-		OOG6_103220
Panther	1	1.100	-	-	LDO	PTHR12937
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1648
SonicParanoid	1	1.000	-	-		X2885
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.840