DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATOH1 and cato

DIOPT Version :9

Sequence 1:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_477344.1	Gene:	cato / 36813	FlyBaseID:	FBgn0024249	Length:	189	Species:	Drosophila melanogaster

Alignment Length:	159	Identity:	63/159 - (39%)
Similarity:	82/159 - (51%)	Gaps:	45/159 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    63 AWLAPTLQGICTARAAQYLLHSPELGASEAAAPRDEVDG---RGELVRRSSGGASSSKSPGPVKV 124
            |:|:|..|.:..|...|     .|||      |..|..|   :.:..|||:   |.:.|.|
  Fly    40 AFLSPEWQFLDAAGGTQ-----TELG------PIMEAQGQHTQPQTKRRSN---SFTGSDG---- 86

Human   125 REQLCKLKGGVVVDELGCSRQRAPSSKQVN---GVQKQRRLAANARERRRMHGLNHAFDQLRNVI 186
                                 |..|.:|.|   .|||:||.|||||||:||:|||.||::||.|:
  Fly    87 ---------------------RKSSPEQTNLSPTVQKRRRQAANARERKRMNGLNAAFERLREVV 130

Human   187 PSFNNDKKLSKYETLQMAQIYINALSELL 215
            |:.:.|:||||:|||||||.||.||.:||
  Fly   131 PAPSIDQKLSKFETLQMAQSYILALCDLL 159

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		9/33 (27%)
		HLH	158..216	CDD:238036	39/58 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		63/159 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354
cato	NP_477344.1	HLH	104..155	CDD:278439	34/50 (68%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4395
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19290
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2611
SonicParanoid	1	1.000	-	-		X4691
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	6.900