DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATOH1 and Oli

DIOPT Version :9

Sequence 1:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001188830.1	Gene:	Oli / 35066	FlyBaseID:	FBgn0032651	Length:	232	Species:	Drosophila melanogaster

Alignment Length:	255	Identity:	75/255 - (29%)
Similarity:	97/255 - (38%)	Gaps:	84/255 - (32%)

- Green bases have known domain annotations that are detailed below.

Human    23 PQPHHLPQPP-----------PPPQPPATLQAREHPVYPPELSLLDSTDPRAWLAPTLQGICTAR 76
            |...|:|.||           |...||.::..|..|        |.|.....:.|   ||
  Fly    14 PNHGHMPIPPTANMLGGQHPAPTASPPQSVPGRRTP--------LGSVGLGGFYA---QG----- 62

Human    77 AAQYLLHSPELGASEAAAPRDEVDGRGELVRRSSGGASSSKSP-GPVKVREQLCKLKGG---VVV 137
                      :|.|: ..|.||          :..|.|:.:.| .|.........:.||   |.|
  Fly    63 ----------MGMSQ-QPPTDE----------NKPGPSAPEKPLSPTAAAIAAIAISGGTTTVAV 106

Human   138 DELGCSRQRAPSSKQVNGVQKQRRLAANARERRRMHGLNHAFDQLRNVIPSFNND--KKLSKYET 200
            ...|.|...:.|.||.|...|..||..|||||||||.||.|.|:||:|||..::.  :||||..|
  Fly   107 SSGGASGSGSNSGKQKNRQGKTVRLNINARERRRMHDLNDALDELRSVIPYAHSPSVRKLSKIAT 171

Human   201 LQMAQIYI----NALSEL------LQTPSG--------------------GEQPPPPPAS 230
            |.:|:.||    |||.||      :|:.:|                    |....||.:|
  Fly   172 LLLAKNYILMQQNALEELRRLLAYIQSTTGAAPLDLGAFPAAAKLQALLQGPHNEPPTSS 231

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55		10/42 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		6/31 (19%)
		HLH	158..216	CDD:238036	35/69 (51%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		6/35 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354
Oli	NP_001188830.1	HLH	134..188	CDD:197674	30/53 (57%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910