DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ATOH1 and CG33557

DIOPT Version :9

Sequence 1:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_001014730.1	Gene:	CG33557 / 3346145	FlyBaseID:	FBgn0053557	Length:	150	Species:	Drosophila melanogaster

Alignment Length:	123	Identity:	41/123 - (33%)
Similarity:	60/123 - (48%)	Gaps:	27/123 - (21%)

- Green bases have known domain annotations that are detailed below.

Human   109 SSGGASSSKSPGPVKVREQLCKLKGGVVVD----ELGCSRQRAPSSKQVNGVQKQR--RLAANAR 167
            |||.||.|                 |...|    ::|  ::..|..::..|..::|  |...|||
  Fly    24 SSGSASGS-----------------GAAADSEDSQIG--QEANPGGQENQGNHRRRPPRQKINAR 69

Human   168 ERRRMHGLNHAFDQLRNVIPSFNNDKKLSKYETLQMAQIYINALSELLQTPSGGEQPP 225
            ||.|...:|.|::.|||:||:...::||||.|.:::|..||..||..|:|  |.|..|
  Fly    70 ERYRTFNVNSAYEALRNLIPTEPMNRKLSKIEIIRLASSYITHLSSTLET--GTECQP 125

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		6/12 (50%)
		HLH	158..216	CDD:238036	25/59 (42%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		4/10 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354
CG33557	NP_001014730.1	HLH	67..119	CDD:197674	24/51 (47%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910