DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ATOH1 and sc

DIOPT Version :9

Sequence 1:	NP_005163.1	Gene:	ATOH1 / 474	HGNCID:	797	Length:	354	Species:	Homo sapiens
Sequence 2:	NP_476803.1	Gene:	sc / 30982	FlyBaseID:	FBgn0004170	Length:	345	Species:	Drosophila melanogaster

Alignment Length:	276	Identity:	69/276 - (25%)
Similarity:	93/276 - (33%)	Gaps:	96/276 - (34%)

- Green bases have known domain annotations that are detailed below.

Human   102 RGELVRRSSGGASS---SKSPGPVKVREQLCKLKGGVVVDELGCSRQRAPSSKQVNGVQKQRRLA 163
            ||..:.|.|...||   ..||.|..|.:                       |:.|     |||
  Fly    70 RGMALTRCSESVSSLSPGSSPAPYNVDQ-----------------------SQSV-----QRR-- 104

Human   164 ANARERRRMHGLNHAFDQLRNVIP-SFNND----------KKLSKYETLQMAQIYINALSELLQT 217
             |||||.|:..:|::|.:||..|| |...|          ||:||.:||::|..||..|.:|:..
  Fly   105 -NARERNRVKQVNNSFARLRQHIPQSIITDLTKGGGRGPHKKISKVDTLRIAVEYIRRLQDLVDD 168

Human   218 PSGGEQPPPPPASCKSDHHHLRTAASYEGGAGNATAAGAQQASGGSQRPTPPGSCRTRFSAPASA 282
            .:||..                              .||..|....|......|..:..|:..|:
  Fly   169 LNGGSN------------------------------IGANNAVTQLQLCLDESSSHSSSSSTCSS 203

Human   283 GGYSV------------QLDALHFSTFEDSALTAMMAQKNL-SPSLPGSILQPVQEENSKTSPRS 334
            .|::.            |...|....|....|||:....|| ..|:||.....|  ..||.....
  Fly   204 SGHNTYYQNTISVSPLQQQQQLQRQQFNHQPLTALSLNTNLVGTSVPGGDAGCV--STSKNQQTC 266

Human   335 HRSDGEFSPHSHYSDS 350
            |      ||.|.::.|
  Fly   267 H------SPTSSFNSS 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ATOH1	NP_005163.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..55
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	91..122		8/22 (36%)
		HLH	158..216	CDD:238036	28/68 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	216..277		7/60 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..354		11/39 (28%)
sc	NP_476803.1	HLH	105..163	CDD:278439	23/57 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910