DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and PIK1

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_014132.1	Gene:	PIK1 / 855454	SGDID:	S000005211	Length:	1066	Species:	Saccharomyces cerevisiae

Alignment Length:	792	Identity:	155/792 - (19%)
Similarity:	266/792 - (33%)	Gaps:	261/792 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly  1644 LLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYE--QL-----------------THF- 1688
            |.|| ||||...    :||....|:.....||:.|.:..:  ||                 |.|
Yeast   385 LEGT-PKLNRTN----SQPLSRQAFKNSKKANSSLSQEIDLSQLSTTSKIKMLKANYFRCETQFA 444

  Fly  1689 --VSTYSQELSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPN 1751
              :.|.||.|:.:|.||      ||.|   ||...:   |.:...|..:       :..|...||
Yeast   445 IALETISQRLARVPTEA------RLSA---LRAELF---LLNRDLPAEV-------DIPTLLPPN 490

  Fly  1752 WYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISL 1816
                              :|..|.|.....|:....:.|......:::..|
Yeast   491 ------------------KKGKLHKLVTITANEAQVLNSAEKVPYLLLIEY-------------- 523

  Fly  1817 IKGNSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQ 1881
                 |:|.       ||:...:|..|.||   |.|..|.                   |.||..
Yeast   524 -----LRDE-------FDFDPTSETNERLL---KKISGNQ-------------------GGLIFD 554

  Fly  1882 L-LMD------------IGKNHPQALVYP-------------LTVASKSASLARRNAAFKILDSM 1920
            | .|:            :..|:.::.||.             |:..|:|.|.:..:...::....
Yeast   555 LNYMNRKENNENRNESTLTSNNTRSSVYDSNSFNNGASRNEGLSSTSRSDSASTAHVRTEVNKEE 619

  Fly  1921 RKHSPTLVEQAVMCSEELIRVAILWHEQWH------EGLEEASRLYFG-------------DRNV 1966
            .....::|:......:|..|.|::.....:      :..:.:..|.||             .:|:
Yeast   620 DLGDMSMVKVRNRTDDEAYRNALVIQSAANVPILPDDSQDRSPELNFGSNLDEVLIENGINSKNI 684

  Fly  1967 KGMFEILEP-------LHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWD 2024
            ....:.|..       :.|.|::.||.|.|                 |.:...:.::..:....|
Yeast   685 HSQTDALADQMRVSAVMLAQLDKSPQQLSE-----------------STKQIRAQIISSMKEVQD 732

  Fly  2025 IY-YHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQV---- 2084
            .: ||                            ||| |:.|.  .|:..:...::...:..
Yeast   733 KFGYH----------------------------DLE-ALHGM--AGERKLENDLMTGGIDTSYLG 766

  Fly  2085 ---ITSKQRPRKLCIRG--SNGKDYMYLLKGHEDLRQDERVMQLF-SLVNTLLLDDPDTFRRNLA 2143
               .|.|:|.||....|  .|......:.|..:||||:....|:. ::.|..:.:..|.:
Yeast   767 EDWATKKERIRKTSEYGHFENWDLCSVIAKTGDDLRQEAFAYQMIQAMANIWVKEKVDVW----- 826

  Fly  2144 IQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEV 2208
            ::|..::..|.|:||:..:.:..::|::.:..  .||:..:.|.......|...||
Yeast   827 VKRMKILITSANTGLVETITNAMSVHSIKKAL--TKKMIEDAELDDKGGIASLNDH--------- 880

  Fly  2209 FEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSG 2273
            |..|.|              :|:...:...::|:..|||..|::.|:|.:.|||..|:|:|. .|
Yeast   881 FLRAFG--------------NPNGFKYRRAQDNFASSLAAYSVICYLLQVKDRHNGNIMIDN-EG 930

  Fly  2274 KILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEG-TYRRTCE---SVMLVLRRNKD 2334
            .:.|||||.....:.....| |..||:||...|:.:  .|:|| .:::..|   |....||:..|
Yeast   931 HVSHIDFGFMLSNSPGSVGF-EAAPFKLTYEYIELL--GGVEGEAFKKFVELTKSSFKALRKYAD 992

  Fly  2335 SLMAVLEAFVYD 2346
            .::::.|....|
Yeast   993 QIVSMCEIMQKD 1004

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	155/792 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	18/123 (15%)
		PIKKc_TOR	2075..2353	CDD:270713	67/286 (23%)
		FATC	2440..2471	CDD:280430
PIK1	NP_014132.1	TEL1	<1..1066	CDD:227365	155/792 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900