DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and TOR2

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_012719.2 Gene:TOR2 / 853632 SGDID:S000001686 Length:2474 Species:Saccharomyces cerevisiae


Alignment Length:2600 Identity:1013/2600 - (38%)
Similarity:1480/2600 - (56%) Gaps:296/2600 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MSTTSVVQQFVNGLKSRNRNVQNKA------------------TQDLLF-YVKTEL--------- 37
            |||||......||.....|.:...|                  |.:|:| .:|:::         
Yeast    42 MSTTSNTDSNHNGPNDSGRVITGSAGHIGKISFVDSELDTTFSTLNLIFDKLKSDVPQERASGAN 106

  Fly    38 ----------REMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEGSL------T 86
                      ||:|.|:..:|.:..::.||.:::....:||.||.||:..||:...|.      |
Yeast   107 ELSTTLTSLAREVSAEQFQRFSNSLNNKIFELIHGFTSSEKIGGILAVDTLISFYLSTEELPNQT 171

  Fly    87 ARKGISPYLNRLRDLLLINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVL-------- 143
            :|     ..|.||.|:..:|:.||.:||.:|.:|.....:..:|..:|:::...:.|        
Yeast   172 SR-----LANYLRVLIPSSDIEVMRLAANTLGRLTVPGGTLTSDFVEFEVRTCIDWLTLTADNNS 231

  Fly   144 RGERQEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTA 208
            ...:.|||||:|:.|::.||...|...|.::.:..:.|:..:.|.|..||..|..||...|.:..
Yeast   232 SSSKLEYRRHAALLIIKALADNSPYLLYPYVNSILDNIWVPLRDAKLIIRLDAAVALGKCLTIIQ 296

  Fly   209 QRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNELFRCANATWERR 273
            .|:   .:...||::..:.......:           :..:|.:|..|:||.||.          
Yeast   297 DRD---PALGKQWFQRLFQGCTHGLS-----------LNTNDSVHATLLVFRELL---------- 337

  Fly   274 YTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKFAS 338
                                              .||.|:                         
Yeast   338 ----------------------------------SLKAPY------------------------- 343

  Fly   339 QHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTCVS 403
                         |::.|..|..:.::.:..|...:::.:..|||.||||:.|:|.:|||...:.
Yeast   344 -------------LRDKYDDIYKSTMKYKEYKFDVIRREVYAILPLLAAFDPAIFTKKYLDRIMV 395

  Fly   404 HLMQILR------GKEKDRTVAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPV 462
            |.::.|:      ....|:....::||.:|..|.|:|..:::.|:.:::..|.:|....|:   .
Yeast   396 HYLRYLKNIDMNAANNSDKPFILVSIGDIAFEVGSSISPYMTLILDNIREGLRTKFKVRKQ---F 457

  Fly   463 DPAVFACITLLAHAVKSEIADDV-KDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGI 526
            :..:|.||..||.|:....|..: ||:|..|....:|..:...|..|:|.:|.|:|.:...::.:
Yeast   458 EKDLFYCIGKLACALGPAFAKHLNKDLLNLMLNCPMSDHMQETLMILNEKIPSLESTVNSRILNL 522

  Fly   527 LSQVLMNKAAIL--PYTALPTIAIDGS--------LMQNG-------DGATTVLALKTLGTFNFE 574
            ||..|..:..|.  .|......:|:.:        :.:.|       |....:...|.|...: .
Yeast   523 LSISLSGEKFIQSNQYDFNNQFSIEKARKSRNQSFMKKTGESNDDITDAQILIQCFKMLQLIH-H 586

  Fly   575 EQNMLDFVQRCADYFIVHEQQEIR-LEAVQTCTRLLK--LAVQSSESMENSKTLSDTVSHVIERL 636
            :.::.:||:.....:|.||...:| |.|:.:|...:|  :..|:|....:|      ||.|:.:|
Yeast   587 QYSLTEFVRLITISYIEHEDSSVRKLAALTSCDLFIKDDICKQTSVHALHS------VSEVLSKL 645

  Fly   637 LMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPA 701
            ||:||||....:|:.||:.|...||.:||||::|..||:.|:||||.|:..|:..||||||:|||
Yeast   646 LMIAITDPVAEIRLEILQHLGSNFDPQLAQPDNLRLLFMALNDEIFGIQLEAIKIIGRLSSVNPA 710

  Fly   702 YVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHEPESN 766
            ||:|.||.|::||:|.||:|.|.:.||:||.:|..|:.|:..:...|::|||..::||..:..| 
Yeast   711 YVVPSLRKTLLELLTQLKFSNMPKKKEESATLLCTLINSSDEVAKPYIDPILDVILPKCQDASS- 774

  Fly   767 PGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRV 831
             .|....|:.:|:|:.|  |..||..:..:|:.:::....|..:..||..||.|||||.:::|.|
Yeast   775 -AVASTALKVLGELSVV--GGKEMTRYLKELMPLIINTFQDQSNSFKRDAALTTLGQLAASSGYV 836

  Fly   832 VTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSD 896
            |.|...||.|:.||||.||||....|||.|:|::|:|||:|||||          ::..:.:.|.
Yeast   837 VGPLLDYPELLGILINILKTENNPHIRRGTVRLIGILGALDPYKH----------REIEVTSNSK 891

  Fly   897 GKVDE-SQDISTAELLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIK 960
            ..|:: :..|..|.|:..:..:.|||||.|.|..||:||.||:||..||:.:||:..|||:||::
Yeast   892 SSVEQNAPSIDIALLMQGVSPSNDEYYPTVVIHNLMKILNDPSLSIHHTAAIQAIMHIFQNLGLR 956

  Fly   961 CVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQN 1025
            ||.:|.|::|.::..:|:...:..:|.||||..|::.||.||..::..|:.:|:||:.| ..||.
Yeast   957 CVSFLDQIIPGIILVMRSCPPSQLDFYFQQLGSLISIVKQHIRPHVEKIYGVIREFFPI-IKLQI 1020

  Fly  1026 TLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFGSTLGYYLPLIL 1090
            |:|::||.|:.||..||:.::.|.:...|.:|::|.|..|:|..|:|::|..||..|..|..||:
Yeast  1021 TIISVIESISKALEGEFKRFVPETLTFFLDILENDQSNKRIVPIRILKSLVTFGPNLEDYSHLIM 1085

  Fly  1091 PPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVL-DAEPELRDQAMTTLRS 1154
            |.:|::  :.|....:..:::.|:..||..::.::.||||:..|||:| :.:.||....|.||..
Yeast  1086 PIVVRM--TEYSAGSLKKISIITLGRLAKNINLSEMSSRIVQALVRILNNGDRELTKATMNTLSL 1148

  Fly  1155 LAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRF---KNN 1216
            |..|||..::||||::.:.|.::||....|::|::|:.:            :|..|:..   |.|
Yeast  1149 LLLQLGTDFVVFVPVINKALLRNRIQHSVYDQLVNKLLN------------NECLPTNIIFDKEN 1201

  Fly  1217 EPFVTDRNSNNKNLQVT-----TNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACR 1276
            |  |.:|.:....:|||     .|.|:.||..:::.:|:||.||::||||.|||||||..||:|.
Yeast  1202 E--VPERKNYEDEMQVTKLPVNQNILKNAWYCSQQKTKEDWQEWIRRLSIQLLKESPSACLRSCS 1264

  Fly  1277 SLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTD-MPEITQTILNLAEFMEHCD 1340
            ||...|..|.|:||||:|.|||.||....:.:|.|:|.:||..:: .|||.|.:|||.|||||.|
Yeast  1265 SLVSVYYPLARELFNASFSSCWVELQTSYQEDLIQALCKALSSSENPPEIYQMLLNLVEFMEHDD 1329

  Fly  1341 RDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEGLLTRYR 1405
            : |:||....||..|..|.|:||||.|||.|||....:...|:||.|||:|.|.::|.|:| ::.
Yeast  1330 K-PLPIPIHTLGKYAQKCHAFAKALHYKEVEFLEEPKNSTIEALISINNQLHQTDSAIGIL-KHA 1392

  Fly  1406 NAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVTKHEWE 1470
            ...|||.::..|||||..|::||..|..........:|..:|.:|.|.|||:|.|||.:...:|.
Yeast  1393 QQHNELQLKETWYEKLQRWEDALAAYNEKEAAGEDSVEVMMGKLRSLYALGEWEELSKLASEKWG 1457

  Fly  1471 NFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRLIDET 1535
            ....|.|....||||.|||||:.|:.:.:|...:...:.|..:|.|:|.:|.::|:.|:..|...
Yeast  1458 TAKPEVKKAMAPLAAGAAWGLEQWDEIAQYTSVMKSQSPDKEFYDAILCLHRNNFKKAEVHIFNA 1522

  Fly  1536 RDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIPERREPLKTM---WWKRLQGGQRL 1597
            ||||.|||:::..|||.|||..:|..|::|||||:|:||.:|:..:...||   |..||.|.|:.
Yeast  1523 RDLLVTELSALVNESYNRAYNVVVRAQIIAELEEIIKYKKLPQNSDKRLTMRETWNTRLLGCQKN 1587

  Fly  1598 VEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSLHLSHKTLVMLL-GTDPKLNPNQPLPCNQ 1661
            ::.|:||::|.|||:||.||....:|:|:||||||.:.|:.|.|..|| .||...:||....  .
Yeast  1588 IDVWQRILRVRSLVIKPKEDAQVRIKFANLCRKSGRMALAKKVLNTLLEETDDPDHPNTAKA--S 1650

  Fly  1662 PQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCLP----PEALKQQDQR----------LM 1712
            |.|.||..||:.|.....||.:||.:|.|..:.:|...|    .:::.||.:|          |:
Yeast  1651 PPVVYAQLKYLWATGLQDEALKQLINFTSRMAHDLGLDPNNMIAQSVPQQSKRVPRHVEDYTKLL 1715

  Fly  1713 ARCYLRMATWQNKLQDSIR---PDAIQGALECFEKATSYDPNWYKAWHLWAYMNFKVVQAQKSAL 1774
            |||:|:...|:..||...|   ||:|.|:   :..||.:|..||||||.||..||:|:....|..
Yeast  1716 ARCFLKQGEWRVCLQPKWRLSNPDSILGS---YLLATHFDNTWYKAWHNWALANFEVISMLTSVS 1777

  Fly  1775 DKQQPPGASMGMTMGSGLDSDLM---------------IIQRYAVPAVQGFFRSISLIKGNSLQD 1824
            .|:|....:..:|..:..|:.::               :|.|:.:||::|||.||||.:.:||||
Yeast  1778 KKKQEGSDASSVTDINEFDNGMIGVNTFDAKEVHYSSNLIHRHVIPAIKGFFHSISLSESSSLQD 1842

  Fly  1825 TLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGKN 1889
            .||||||||.:|...|..:|:..|..||:|.|||:|:||||:||....|:|.:.:..||.|:||.
Yeast  1843 ALRLLTLWFTFGGIPEATQAMHEGFNLIQIGTWLEVLPQLISRIHQPNQIVSRSLLSLLSDLGKA 1907

  Fly  1890 HPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVAILWHEQWHEGLE 1954
            |||||||||.||.||.||:|:.||..|::.||.|||.||:||.:.|.||||:|:||||||:|||:
Yeast  1908 HPQALVYPLMVAIKSESLSRQKAALSIIEKMRIHSPVLVDQAELVSHELIRMAVLWHEQWYEGLD 1972

  Fly  1955 EASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDL 2019
            :|||.:||:.|.:.||..||||:.||:|||:||:|.||..::||:|.:||||...||.|..|.:|
Yeast  1973 DASRQFFGEHNTEKMFAALEPLYEMLKRGPETLREISFQNSFGRDLNDAYEWLMNYKKSKDVSNL 2037

  Fly  2020 DRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGS-YNPGQELIRISIIKTNLQ 2083
            ::||||||:||:||.:|||||.:|||.:|||||::..||||||||: .:.|:.:::||..:....
Yeast  2038 NQAWDIYYNVFRKIGKQLPQLQTLELQHVSPKLLSAHDLELAVPGTRASGGKPIVKISKFEPVFS 2102

  Fly  2084 VITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYA 2148
            ||:|||||||.||:||:||||.|:||||||:|||..|||||.||||||.:|.:.|||:|.||:|.
Yeast  2103 VISSKQRPRKFCIKGSDGKDYKYVLKGHEDIRQDSLVMQLFGLVNTLLQNDAECFRRHLDIQQYP 2167

  Fly  2149 VIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHAL 2213
            .||||..|||:||||:.||.|.|||::|:.||:|||.||..||..|||||:|||:||||||.:||
Yeast  2168 AIPLSPKSGLLGWVPNSDTFHVLIREHREAKKIPLNIEHWVMLQMAPDYDNLTLLQKVEVFTYAL 2232

  Fly  2214 GQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHI 2278
            ..|:|.||.|:|||||.|||.|.|||..||||||||||.||||||||||||||||||::||::||
Yeast  2233 NNTEGQDLYKVLWLKSRSSETWLERRTTYTRSLAVMSMTGYILGLGDRHPSNLMLDRITGKVIHI 2297

  Fly  2279 DFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAF 2343
            |||||||.|:.|||||||:||||||||..||||:||||::|.|||:||.|||.||.||||:||||
Yeast  2298 DFGDCFEAAILREKFPEKVPFRLTRMLTYAMEVSGIEGSFRITCENVMKVLRDNKGSLMAILEAF 2362

  Fly  2344 VYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNS--VEDSLPMAKSKPYDPTLQQGG 2406
            .:|||:||. .|:..|..:...|...|    .....:.|||.  .|:.:...:::          
Yeast  2363 AFDPLINWG-FDLPTKKIEEETGIQLP----VMNANELLSNGAITEEEVQRVENE---------- 2412

  Fly  2407 LHNNVADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
             |.|..  .|::|..|:||:..||||.|.:....::...||:.||||||:.|||||.||||||||
Yeast  2413 -HKNAI--RNARAMLVLKRITDKLTGNDIRRFNDLDVPEQVDKLIQQATSVENLCQHYIGWCPFW 2474

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 936/2239 (42%)
HEAT repeat 632..658 CDD:293787 12/25 (48%)
HEAT repeat 668..698 CDD:293787 15/29 (52%)
HEAT repeat 706..736 CDD:293787 15/29 (52%)
HEAT repeat 749..780 CDD:293787 9/30 (30%)
HEAT repeat 798..823 CDD:293787 7/24 (29%)
DUF3385 831..999 CDD:288698 69/168 (41%)
HEAT repeat 841..870 CDD:293787 16/28 (57%)
HEAT repeat 880..917 CDD:293787 5/37 (14%)
HEAT repeat 925..954 CDD:293787 14/28 (50%)
Rapamycin_bind 1937..2034 CDD:285924 57/96 (59%)
PIKKc_TOR 2075..2353 CDD:270713 195/277 (70%)
FATC 2440..2471 CDD:280430 19/30 (63%)
TOR2NP_012719.2 TEL1 290..2474 CDD:227365 947/2345 (40%)
HEAT repeat 599..620 CDD:293787 7/20 (35%)
HEAT repeat 642..667 CDD:293787 11/24 (46%)
HEAT repeat 677..707 CDD:293787 15/29 (52%)
HEAT repeat 715..748 CDD:293787 16/32 (50%)
HEAT repeat 758..787 CDD:293787 9/30 (30%)
HEAT repeat 801..828 CDD:293787 8/26 (31%)
HEAT repeat 843..873 CDD:293787 17/29 (59%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 368 1.000 Domainoid score I119
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3637
Inparanoid 1 1.050 1604 1.000 Inparanoid score I8
Isobase 1 0.950 - 0.896241 Normalized mean entropy S1632
OMA 1 1.010 - - QHG53650
OrthoFinder 1 1.000 - - FOG0003052
OrthoInspector 1 1.000 - - otm46830
orthoMCL 1 0.900 - - OOG6_100794
Panther 1 1.100 - - LDO PTHR11139
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R1538
SonicParanoid 1 1.000 - - X2407
TreeFam 1 0.960 - -
1514.810

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