DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and Pik3cb

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_445933.1 Gene:Pik3cb / 85243 RGDID:620917 Length:1070 Species:Rattus norvegicus


Alignment Length:1071 Identity:225/1071 - (21%)
Similarity:382/1071 - (35%) Gaps:308/1071 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly  1490 GLQDWEAMREYVRCIPEDTQDGSYYRAVLAVHHDDFETAQRL--IDETRDLLDTELTSMAGESYE 1552
            ||.:::|::        |.:...:.|.:.....|..::...|  ||..:.....|......|:.|
  Rat   133 GLHEFDALK--------DPEVNEFRRKMRKFSEDKIQSLVGLSWIDWLKHTYPPEHEPSVLENLE 189

  Fly  1553 -RAYGAMVCVQMLAE-LEEVIQYKLIPERREPLK---TMWWKRL--QGGQRLVEDWRRIIQVHSL 1610
             :.||..:.|.:..| .::|..:::.| ...|:|   ....|||  :|.:........::||...
  Rat   190 DKLYGGKLVVAVHFENSQDVFSFQVSP-NLNPIKINELAIQKRLTIRGKEEEASPCDYVLQVSGR 253

  Fly  1611 VVKPHEDIHTWLKYASLCRKSGSLHLSHKTLV-----------MLLGTDPKLNPNQ---PLPCNQ 1661
            |.....| |..:::..:.....:..|.|..||           .::..:..:|.|.   |||. .
  Rat   254 VEYVFGD-HPLIQFQYIRNCVMNRTLPHFILVECCKIKKMYEQEMIAIEAAINRNSSSLPLPL-P 316

  Fly  1662 PQVTYAYTKYMAANNQLQ---------EAYEQLTHFVST---YSQELSC---LPPEALKQQDQRL 1711
            |:.|...:.....||..|         ...|.:...|..   :..||.|   :..|...:.|.  
  Rat   317 PKKTRVISHVWGNNNPFQIVLVKGNKLNTEETVKVHVRAGLFHGTELLCKTVVSSEISGKNDH-- 379

  Fly  1712 MARCYLRMATWQNKLQDSIR-PDAIQGALECF-----------EKAT-SYDPNWYKAWHLWAYMN 1763
                     .|..:|:..|. .|..:.|..||           :|:| :.:|:.|:.......::
  Rat   380 ---------IWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKSTKTINPSKYQTIRKAGKVH 435

  Fly  1764 FKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVP-AVQGFFRSISLIKGNSLQDTLR 1827
            :.|........|.:           |.....|:::....:.| .::.....:..::.|...:...
  Rat   436 YPVAWVNTMVFDFK-----------GQLRSGDVILHSWSSFPDELEEMLNPMGTVQTNPYAENAT 489

  Fly  1828 LLTLWFDYGNHAEVY----EALLSGMKLIEI-------------NTWLQVIPQLIARIDTHRQLV 1875
            .|.:.|........|    :.::.  |..||             ..:|.|:.:::.| |...||.
  Rat   490 ALHIKFPENKKQPYYYPPFDKIIE--KAAEIASGDSANVSSRGGKKFLAVLKEILDR-DPLSQLC 551

  Fly  1876 G---QLIHQLLMDIGKNHPQALVYPLTVAS----KSASLARRNA------------AFKILD--- 1918
            .   .||..|..|..:|.||:|  |..:.|    |...:|:..|            |.::||   
  Rat   552 ENEMDLIWTLRQDCRENFPQSL--PKLLLSIKWNKLEDVAQLQALLQIWPKLPPREALELLDFNY 614

  Fly  1919 ---SMRKHSPTLVEQAVMCSEELIR-----VAILWHEQWHEG------LEEASRLYFGDRNVKGM 1969
               .:|:::...:.|  |..|||.:     |.:|.:|.:.:.      ||.|    ..:|.: |.
  Rat   615 PDQYVREYAVGCLRQ--MSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERA----LDNRRI-GQ 672

  Fly  1970 F-------EILEP-----LHAMLE---RGPQTLKETSFSQAYGRELTEAYEWSQRYKT--SAV-- 2015
            |       |:..|     ...:||   ||         |..:.:.|::..|...:.||  |.:  
  Rat   673 FLFWHLRSEVHTPAVSIQFGVILEAYCRG---------SVGHMKVLSKQVEALNKLKTLNSLIKL 728

  Fly  2016 -VMDLDRA-WDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISII 2078
             .|.|:|| .....|...|.|.....|:.|:.|                   .||...|..:.:.
  Rat   729 NAMKLNRAKGKEAMHTCLKQSAYREALSDLQSP-------------------LNPCVILSELYVE 774

  Fly  2079 KTNLQVITSKQRPRKLCIRGSN---GKDYM-YLLKGHEDLRQDERVMQLFSLVNTLL----LDDP 2135
            |  .:.:.||.:|  |.:..||   |:|.: .:.|..:|||||...:|:..|::.|.    ||  
  Rat   775 K--CRYMDSKMKP--LWLVYSNRAFGEDAVGVIFKNGDDLRQDMLTLQMLRLMDLLWKEAGLD-- 833

  Fly  2136 DTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEH---------RTML 2191
                  |.:..|..:.....||||..|...:|:          ..:.||..:         ..:|
  Rat   834 ------LRMLPYGCLATGDRSGLIEVVSTSETI----------ADIQLNSSNVAATAAFNKDALL 882

  Fly  2192 NFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYIL 2256
            |:..:|:                  .||||.:.:              ..:|.|.|...:..|:|
  Rat   883 NWLKEYN------------------SGDDLDRAI--------------EEFTLSCAGYCVASYVL 915

  Fly  2257 GLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTRMLIKAME--VTGIE- 2315
            |:||||..|:|: :.:|::.|||||..  :...:.||   .|::||.||...|..::  .||.. 
  Rat   916 GIGDRHSDNIMV-KKTGQLFHIDFGHI--LGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTE 977

  Fly  2316 --GTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGM 2378
              |.:|:.||...|:|||: .:|...|.|.:..                    ||.|.......:
  Rat   978 KFGRFRQCCEDAYLILRRH-GNLFITLFALMLT--------------------AGLPELTSVKDI 1021

  Fly  2379 Q---DSLS--NSVEDSLPMAKSKPYDPTLQQ 2404
            |   |||:  .|.|::|...|.| :|..|::
  Rat  1022 QYLKDSLALGKSEEEALKQFKQK-FDEALRE 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 225/1071 (21%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 29/128 (23%)
PIKKc_TOR 2075..2353 CDD:270713 76/302 (25%)
FATC 2440..2471 CDD:280430
Pik3cbNP_445933.1 PI3K_p85B 41..118 CDD:197539
PI3K_rbd 180..288 CDD:197540 23/109 (21%)
C2_PI3K_class_I_beta_delta 324..501 CDD:176075 29/198 (15%)
Nuclear localization signal (NLS). /evidence=ECO:0000250 410..418 1/7 (14%)
PI3Ka_I 532..702 CDD:238444 43/188 (23%)
PI3Kc_IA_beta 706..1067 CDD:270717 108/444 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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