Protein Alignment mTor and TOR

DIOPT Version :10

• Sequence 1: NP_001260427.1
• Gene: mTor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: NP_175425.2
• Gene: TOR / 841427
• AraportID: AT1G50030
• Length: 2481
• Species: Arabidopsis thaliana
• Alignment Length: 2571
• Identity: 1024/2571 - (39%)
• Similarity: 1465/2571 - (56%)
• Gaps: 285/2571 - (11%)

  Fly    32 YVKTELREMSQEELAQFFDEFDHHIFTMVNATDINEKKGGALAMKCLINCEGSLTARKGISPYLN 96
            :|:..:|::|.|..::|.::....|..::.:||:.|..|...|:..|........|.| :|.:..
plant    65 HVEEAVRDLSGEASSRFMEQLYDRIANLIESTDVAENMGALRAIDELTEIGFGENATK-VSRFAG 128

  Fly    97 RLRDLL-LINDVSVMEIAARSLVKLANMPTSKGADSFDFDIKKAFEVLRGERQEYRRHSAVFILR 160
            .:|.:. |..|..::.:|:|.|..||....:..:|..:|.:|.||:.||.:|.||||.:||.||:
plant   129 YMRTVFELKRDPEILVLASRVLGHLARAGGAMTSDEVEFQMKTAFDWLRVDRVEYRRFAAVLILK 193

  Fly   161 ELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRIC 225
            |:|....|.|..|:..|.:.|:.|:.||:..:||.|.|||||.|.|..:||:..:   .|||...
plant   194 EMAENASTVFNVHVPEFVDAIWVALRDPQLQVRERAVEALRACLRVIEKRETRWR---VQWYYRM 255

  Fly   226 YDEANGSFNADLGSSKDQKGVTRD---DRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHN 287
            ::..             |.|:.|:   ..|||.|:...||.|
plant   256 FEAT-------------QDGLGRNAPVHSIHGSLLAVGELLR----------------------- 284

  Fly   288 KFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGEGEHHKGVAKFASQHNVLESAYAQEIL 352
                           ||                                            .|.:
plant   285 ---------------NT--------------------------------------------GEFM 290

  Fly   353 QEHYTSICDNVLEQRTSKSPYVQQALLQILPRLAAFNRAVFVEKYLQTCVSHLMQILRGKEKDRT 417
            ...|..:.:.||.....:...|:.::..:|||:|.|.|..||..||..|::|::.:|| ...:|.
plant   291 MSRYREVAEIVLRYLEHRDRLVRLSITSLLPRIAHFLRDRFVTNYLTICMNHILTVLR-IPAERA 354

  Fly   418 VAYITIGYMAVAVQSAIEVHLSSIMTSVKVALPSKDLTSKRKVPVDPAVFACITLLAHAVKSEIA 482
            ..:|.:|.||.|:...:..:|.:||:.::.|     :..::..|:..|| ||:..:|.|:.|.:.
plant   355 SGFIALGEMAGALDGELIHYLPTIMSHLRDA-----IAPRKGRPLLEAV-ACVGNIAKAMGSTVE 413

  Fly   483 DDVKDILEQMFYTGLSPALTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYT-ALPTI 546
            ..|:|:|:.||.:.||..|...|.:::.::|.|...:.:.|:..:|.||...    .|: |.|.:
plant   414 THVRDLLDVMFSSSLSSTLVDALDQITISIPSLLPTVQDRLLDCISLVLSKS----HYSQAKPPV 474

  Fly   547 AI-----DGSLMQNGD---GATTVLALKTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQ 603
            .|     .|...|:.|   .|...|||:||..|||:..::|:|.:.....::..|....|.:|..
plant   475 TIVRGSTVGMAPQSSDPSCSAQVQLALQTLARFNFKGHDLLEFARESVVVYLDDEDAATRKDAAL 539

  Fly   604 TCTRLLKLAVQ------SSESMENSKTLSDTVSHVIERLLMVAITDMDCNVRIRILRSL--DETF 660
            .|.||:..::.      ||.|..........|..::|:||..|:.|.|..||..|..:|  ::.|
plant   540 CCCRLIANSLSGITQFGSSRSTRAGGRRRRLVEEIVEKLLRTAVADADVTVRKSIFVALFGNQCF 604

  Fly   661 DGKLAQPESLNSLFITLHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSR 725
            |..|||.:||.::|.:|:||..::||.|:...||||..|||||:|.||..:|:|:|.|:.|..::
plant   605 DDYLAQADSLTAIFASLNDEDLDVREYAISVAGRLSEKNPAYVLPALRRHLIQLLTYLELSADNK 669

  Fly   726 NKEQSAKMLDHLVISTPRLISSYMNPILKALVPKLHE---PESNPGVILNVLRTIGDLAEVNGGS 787
            .:|:|||:|..||.:..|||..|:.|:.||||.:|.|   ..:|..::..||.|:||||.|.|.:
plant   670 CREESAKLLGCLVRNCERLILPYVAPVQKALVARLSEGTGVNANNNIVTGVLVTVGDLARVGGLA 734

  Fly   788 DEMELWADDLLSILLEMLGDAGSPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTE 852
              |..:..:|:.:::|.|.|..:..||.||:.||||::.:||.|||||.:||:|:.:|:..||.:
plant   735 --MRQYIPELMPLIVEALMDGAAVAKREVAVSTLGQVVQSTGYVVTPYKEYPLLLGLLLKLLKGD 797

  Fly   853 QRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDI-STAELLVNMGN 916
            ...|.|||.::|||::||:||:.||.|:..:......|    ..|..|..|.| |..||.|.:..
plant   798 LVWSTRREVLKVLGIMGALDPHVHKRNQQSLSGSHGEV----PRGTGDSGQPIPSIDELPVELRP 858

  Fly   917 AL---DEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRT 978
            :.   ::||..|||.:|||||||.:|.:.|..||:::..||:|:|:.|||||.:|||.|...|||
plant   859 SFATSEDYYSTVAINSLMRILRDASLLSYHKRVVRSLMIIFKSMGLGCVPYLPKVLPELFHTVRT 923

  Fly   979 ADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFW---TINTPLQNT----LINLIEQIAV 1036
            :|.||::|:...|..||:.|:.||..|:.::..|:.|.|   |:..|::.:    :::|:|.:.:
plant   924 SDENLKDFITWGLGTLVSIVRQHIRKYLPELLSLVSELWSSFTLPGPIRPSRGLPVLHLLEHLCL 988

  Fly  1037 ALGCEFRDYLAELIPQILRVL-QHDNSKDRMVTRRLLQALQKFGSTLGYYLPLILPPIVKLF--D 1098
            ||..|||.||..::|..::|| ..:...|......:|..|:.||.||..::.|:||.:::||  |
plant   989 ALNDEFRTYLPVILPCFIQVLGDAERFNDYTYVPDILHTLEVFGGTLDEHMHLLLPALIRLFKVD 1053

  Fly  1099 SPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAE-PELRDQAMTTLRSLAKQLGKK 1162
            :|..   :...|::|:..:...:..|...|.::|.|..|||.: .|||..|:..|..||..||:.
plant  1054 APVA---IRRDAIKTLTRVIPCVQVTGHISALVHHLKLVLDGKNDELRKDAVDALCCLAHALGED 1115

  Fly  1163 YLVFVPMVQRTLNKHRIVDPEYEELLSK--------IKSCSTLADSYGAGESELRPSRFKNN-EP 1218
            :.:|:..:.:.|.|||:...|:||:.::        :.:.:|...|.......:|....:|. :|
plant  1116 FTIFIESIHKLLLKHRLRHKEFEEIHARWRRREPLIVATTATQQLSRRLPVEVIRDPVIENEIDP 1180

  Fly  1219 FV--TDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRACRSLAQE 1281
            |.  ||||.     ||....||||.:.::|.:|:||.||::..||.|||||||.|||.|..|||.
plant  1181 FEEGTDRNH-----QVNDGRLRTAGEASQRSTKEDWEEWMRHFSIELLKESPSPALRTCAKLAQL 1240

  Fly  1282 YDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDM-PEITQTILNLAEFMEHCDRDPIP 1345
            ...:.|:||.|.|:|||.:|:...:.:|.:||..|....:: |||..|:||||||||| |..|:|
plant  1241 QPFVGRELFAAGFVSCWAQLNESSQKQLVRSLEMAFSSPNIPPEILATLLNLAEFMEH-DEKPLP 1304

  Fly  1346 IETKLLGTRAMACRAYAKALRYKEEEF----LLREDSQ---VFESLILINNKLQQREAAEGLLTR 1403
            |:.:|||..|..||.:||||.|||.||    ..|.|:.   |.|:||.|||:|.|.|||.|:||
plant  1305 IDIRLLGALAEKCRVFAKALHYKEMEFEGPRSKRMDANPVAVVEALIHINNQLHQHEAAVGILT- 1368

  Fly  1404 YRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSSD-----LEARLGHMRCLEALGDWSELSN 1463
            |.....::.::..|||||..||:||:.|  .||...:.     |||.||.||||.||..|.||:|
plant  1369 YAQQHLDVQLKESWYEKLQRWDDALKAY--TLKASQTTNPHLVLEATLGQMRCLAALARWEELNN 1431

  Fly  1464 VTKHEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYVRCI-------------PEDTQDGS--- 1512
            :.|..|......|:....|:||.|||.:.:|:.|.|||..:             |..:.|||
plant  1432 LCKEYWSPAEPSARLEMAPMAAQAAWNMGEWDQMAEYVSRLDDGDETKLRGLASPVSSGDGSSNG 1496

  Fly  1513 -YYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLI 1576
             ::||||.|....::.|:..::..|..|.|||.::..|||||||..||.||.|:||||||:|..:
plant  1497 TFFRAVLLVRRAKYDEAREYVERARKCLATELAALVLESYERAYSNMVRVQQLSELEEVIEYYTL 1561

  Fly  1577 P-------ERREPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDIHTWLKYASLCRKSGSL 1634
            |       |||..::.||.:|:||.:|.||.|:.::.|.:||:.|.||:.||||:||||||||.:
plant  1562 PVGNTIAEERRALIRNMWTQRIQGSKRNVEVWQALLAVRALVLPPTEDVETWLKFASLCRKSGRI 1626

  Fly  1635 HLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKY---MAANNQLQEAYEQLTHFVSTYSQEL 1696
            ..:..||:.||..||:::|........|||...|.||   :....:.:||:.:|    ...::||
plant  1627 SQAKSTLLKLLPFDPEVSPENMQYHGPPQVMLGYLKYQWSLGEERKRKEAFTKL----QILTREL 1687

  Fly  1697 SCLPPE---------ALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNW 1752
            |.:|..         :.|..:..|:||..|::.|||..|...:...:||...:.|:|:|.|.|.|
plant  1688 SSVPHSQSDILASMVSSKGANVPLLARVNLKLGTWQWALSSGLNDGSIQEIRDAFDKSTCYAPKW 1752

  Fly  1753 YKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISL- 1816
            .||||.||..|..|                 |...:..|     .|..:|.|.||.|:|.||:.
plant  1753 AKAWHTWALFNTAV-----------------MSHYISRG-----QIASQYVVSAVTGYFYSIACA 1795

  Fly  1817 --IKG--NSLQDTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQ 1877
              .||  :||||.||||||||::|..|:|..||.:|...:.|||||.|:||:||||.::.:.|.:
plant  1796 ANAKGVDDSLQDILRLLTLWFNHGATADVQTALKTGFSHVNINTWLVVLPQIIARIHSNNRAVRE 1860

  Fly  1878 LIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVMCSEELIRVA 1942
            ||..||:.||:||||||:|||.||.||.|..||.||.:::|.:|:||..||:||.:.|.||||||
plant  1861 LIQSLLIRIGENHPQALMYPLLVACKSISNLRRAAAQEVVDKVRQHSGALVDQAQLVSHELIRVA 1925

  Fly  1943 ILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQ----TLKETSFSQAYGRELTEA 2003
            |||||.|||.||||||||||:.|::||.::|||||.||:.|.:    |::|.:|.:||..||.||
plant  1926 ILWHEMWHEALEEASRLYFGEHNIEGMLKVLEPLHDMLDEGVKKDSTTIQERAFIEAYRHELKEA 1990

  Fly  2004 YEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNP 2068
            :|....||.:....:|.:|||:|||||::|.:||..||:|:|..|||:|:.|:||||||||:|..
plant  1991 HECCCNYKITGKDAELTQAWDLYYHVFKRIDKQLASLTTLDLESVSPELLLCRDLELAVPGTYRA 2055

  Fly  2069 GQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKDYMYLLKGHEDLRQDERVMQLFSLVNTLLLD 2133
            ...::.||.....|.|||||||||||.|.|::|:||.:||||||||||||||||||.||||||.:
plant  2056 DAPVVTISSFSRQLVVITSKQRPRKLTIHGNDGEDYAFLLKGHEDLRQDERVMQLFGLVNTLLEN 2120

  Fly  2134 DPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRTMLNFAPDYD 2198
            ...|..::|:||||:|||||.|||||||||:|||||.|||::||.:|:.||||::.||:||||||
plant  2121 SRKTAEKDLSIQRYSVIPLSPNSGLIGWVPNCDTLHHLIREHRDARKIILNQENKHMLSFAPDYD 2185

  Fly  2199 HLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHP 2263
            :|.|:.||||||:||..|:|:||:::|||||.|||:|.|||.|||||||||||||||||||||||
plant  2186 NLPLIAKVEVFEYALENTEGNDLSRVLWLKSRSSEVWLERRTNYTRSLAVMSMVGYILGLGDRHP 2250

  Fly  2264 SNLMLDRMSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLV 2328
            |||||.|.||||||||||||||.:|.|||||||:||||||||:|||||:||||.:|.|||:||.|
plant  2251 SNLMLHRYSGKILHIDFGDCFEASMNREKFPEKVPFRLTRMLVKAMEVSGIEGNFRSTCENVMQV 2315

  Fly  2329 LRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPM- 2392
            ||.||||:||::||||:|||:||||.:.::....|:.|...|.........:...:..:..||.
plant  2316 LRTNKDSVMAMMEAFVHDPLINWRLFNFNEVPQLALLGNNNPNAPADVEPDEEDEDPADIDLPQP 2380

  Fly  2393 AKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTGTDF---------------------- 2435
            .:|......||...:..:..:..|.:|..|:.|:..||||.||
plant  2381 QRSTREKEILQAVNMLGDANEVLNERAVVVMARMSHKLTGRDFSSSAIPSNPIADHNNLLGGDSH 2445

  Fly  2436 QTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
            :.|..::.:.||:.||.|||::|||||.|:||||||
plant  2446 EVEHGLSVKVQVQKLINQATSHENLCQNYVGWCPFW 2481

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mTor	NP_001260427.1	TEL1	308..2471	CDD:227365	946/2289 (41%)
		HEAT repeat	632..658	CDD:293787	10/27 (37%)
		HEAT repeat	668..698	CDD:293787	13/29 (45%)
		HEAT repeat	706..736	CDD:293787	12/29 (41%)
		HEAT repeat	749..780	CDD:293787	12/33 (36%)
		HEAT repeat	798..823	CDD:293787	9/24 (38%)
		HEAT repeat	841..870	CDD:293787	11/28 (39%)
		HEAT repeat	880..917	CDD:293787	9/37 (24%)
		HEAT repeat	925..954	CDD:293787	14/28 (50%)
TOR	NP_175425.2	HEAT_EZ	185..233	CDD:463906	19/47 (40%)
		TEL1	271..2481	CDD:227365	955/2346 (41%)
		HEAT repeat	575..603	CDD:293787	10/27 (37%)
		HEAT repeat	612..642	CDD:293787	13/29 (45%)
		HEAT repeat	650..680	CDD:293787	12/29 (41%)
		HEAT repeat	693..727	CDD:293787	12/33 (36%)
		HEAT repeat	739..769	CDD:293787	11/29 (38%)