Protein Alignment mTor and ATR

DIOPT Version :10

• Sequence 1: NP_001260427.1
• Gene: mTor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: NP_001332644.1
• Gene: ATR / 834082
• AraportID: AT5G40820
• Length: 2703
• Species: Arabidopsis thaliana
• Alignment Length: 2725
• Identity: 539/2725 - (19%)
• Similarity: 970/2725 - (35%)
• Gaps: 901/2725 - (33%)

  Fly    91 ISPYLNRLRDLLLI-------------NDVSVMEIAAR-------------SLVK----LANMPT 125
            ||.||..:.:|||:             ||:..::...:             ||||    ...:.|
plant   536 ISIYLEGIHNLLLVAGVDPQYEYTSKGNDLVAIQFLLKLPWTHYMLFKTPSSLVKSKCLSVGIWT 600

  Fly   126 SKG-ADSFDFDIKKAFE-VLRGERQEYRRHSAVFI-LRELAIALPTYFY-----QHILTFFEVIF 182
            ..| .|..||||   |. .|..:.::.:..:|:.: |:.|...|....:     :|:|...|::.
plant   601 KLGLQDGSDFDI---FSWSLSDDFEQVQAVAAISMPLKVLFSGLGALLHMFPKLEHLLEEKELMI 662

  Fly   183 NAIFDPKPAIRESAGEALRAALIVTAQRESTKQSSEPQWYRICYDEANGSFNADLGSSKDQKGVT 247
                  |.||.:|.|      .:......||..|.:...:.:.:::.          .||:   |
plant   663 ------KKAIPQSLG------FLSCLYGSSTTDSEKTACHLLLHEDL----------KKDE---T 702

  Fly   248 RDDRIHGGLVVFNELFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVP 312
            .:..:.|        |||:..                  :||:|.........        ::.|
plant   703 LNSLLQG--------FRCSKC------------------DKFIEREDEKHFRI--------IETP 733

  Fly   313 FIDKLGSTQTHLGEGEHHKGVAKFASQHNVLESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQA 377
            .:.||        :.:||:       .:..|:|.|.             |:|...:|:.  .|.|
plant   734 EMVKL--------KMDHHR-------DYFNLQSLYF-------------NLLYDESSEE--TQLA 768

  Fly   378 LLQILPRLAAFNRA-VFVEKYLQ--TCVSHLMQILRGKEKDRTVAYITIGYMAVAVQSAIEVHLS 439
            .::::.|:...... :.|....|  .|:.:|:..:....::...|.|     .:.||..|
plant   769 CVEVIRRILGHTSPDILVRTRSQWIRCLQYLLVHVNTDVREAFCAQI-----GIFVQHPI----- 823

  Fly   440 SIMTSVKVALPSKDLTSKRKVPVDPAVFAC----ITLLAHAVKSEIADDVKDILEQMFYTGLSPA 500
                 |.....|:|.|.|          :|    ..|:.|::.:     .||:|
plant   824 -----VSCLFLSEDATEK----------SCERNFFNLIEHSLAA-----AKDLL----------- 857

  Fly   501 LTVCLRELSENVPQLKSAITEGLIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLAL 565
                                     ::..:|...|.::       :|:|         .|:.|.|
plant   858 -------------------------VIQTLLETTAEVM-------VAVD---------VTSELFL 881

  Fly   566 KTLGTFNFEEQNMLDFVQRCADYFIVHEQQEIRLEAVQTCTRLLKLAVQSSESMENSKTLSDTVS 630
            ..|    |...:.||           |....:|:.|.:...|...:.|:...:     ||..|.|
plant   882 ICL----FLLIDQLD-----------HPNLIVRINASKLINRSCYIHVKGGFA-----TLLSTAS 926

  Fly   631 HVIERLLMVAITDMDCNVRIRILRSLDETFDGKLAQPESLNSLFITLHDEIFEIRELAMVTIG-- 693
            |:                                 |.|..::|.:.|......:||.|...:|
plant   927 HI---------------------------------QNELFDNLSVRLTSRPNVVREFAEAVLGVE 958

  Fly   694 ---RLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVISTPRLISSYMNPILKA 755
               .:..:.|| |:|||          |.|   .:...|:|..|:.|.    :||.:.:.|::..
plant   959 TEELVRKMVPA-VLPKL----------LVY---WQENAQAANTLNELA----KLIDTDVVPLIVN 1005

  Fly   756 LVPKL------HEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEM-----LGDAG 809
            .:|::      .|.:.|   :|:||:    |.....|||..|::|..|.::|.|:     :.|..
plant  1006 WLPRVLAFALNQEEDKN---LLSVLQ----LYHSQIGSDNQEIFAAALPALLDELVCFVDIADTP 1063

  Fly   810 SPDKRGVALWTLGQLISATGRVVTPYHKYPVLIDILINFLKTEQRRSIRRETIRVLGLLGAMDPY 874
            ..|:|   |..|...|....:|:|.....|       .||:.           ..:|||.::|
plant  1064 ETDRR---LQRLPDAIKKISKVLTNAEDLP-------GFLQN-----------HFVGLLNSID-- 1105

  Fly   875 KHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAELLVN-MGNALDEYYPAVAIAALMRILRDPT 938
             .||      ...|::.:        :.|.:...:||:. ||:.|..|.|.:.:..:..|.:|
plant  1106 -RKM------LHADDIFL--------QKQALKRIKLLIEMMGHYLSTYVPKLMVLLMHAIEKD-- 1153

  Fly   939 LSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLDNVRTADNNLREFLFQQLAILVAFVKL--- 1000
                          ..||.|:..:.:..:.|.::      :.::::..:.|..|.|:.|::.
plant  1154 --------------ALQSEGLLVLHFFTRKLADV------SPSSIKYVISQIFAALIPFLEKEKE 1198

  Fly  1001 --HIISYMGDIFKLIKEFWTIN----------------TPLQNTLINLIEQI--AVALGCEFRDY 1045
              |:  |:.::.|:::|....|                .|....|.|.|::.  .::|..:.||
plant  1199 GPHV--YLDEVVKILEELVLKNRDIVKEHICEFPLLPSIPSLGELNNAIQEARGLMSLKDQLRD- 1260

  Fly  1046 LAELIPQILRVLQHDNSKDR-----------------------------------MVTRRLLQAL 1075
                   |:..::|:|...|                                   ::|..|....
plant  1261 -------IVNGMKHENLNVRYMVACELSKLLYNRNEDVAALIAGELVSDMEILSSLITYLLQGCA 1318

  Fly  1076 QKFGSTLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHP-LVRVLD 1139
            ::..:|:|..|.|:....:....: ..|.:|.:.:.... .:.|..|  |....:||. |.|...
plant  1319 EESRTTVGQRLKLVCADCLGAIGA-IDPAKVRVASCSRF-KIQCSDD--DLIFELIHKHLARAFR 1379

  Fly  1140 AEPE--LRDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYG 1202
            |..:  ::|.|...::.|.|..|.:..:...:|..|..:|..|:      :|..:.|
plant  1380 AAQDTIIQDSAALAIQELLKIAGCEPSLAGNVVVLTPQEHVQVN------VSGSRRC-------- 1430

  Fly  1203 AGESELRP------SRFKNN-----EPFVTDRNSNNKNLQV-TTNELRTAWQVTR-RVSKDDWVE 1254
            .|.:|::.      .||.|.     .|.:|.|      .|: ..::..:|..:.| .:|...|:.
plant  1431 GGNNEVKDRGQKLWDRFSNYVKELIAPCLTSR------FQLPNVSDPGSAGPIYRPSMSFRRWLS 1489

  Fly  1255 -WLKRLSI--------------GLLKESPS---------------HALRACR-SLAQEYDTLL-- 1286
             |:::|:.              |:::....               |...|.| |:::|..::|
plant  1490 YWIRKLTAFATGSRVSIFAACRGIVRHDMQTATYLLPYLVLDVVCHGTEAARLSISEEILSVLDA 1554

  Fly  1287 ------------------RDLFNAAF-----ISCWT-------------------ELSPDLKNEL 1309
                              .....|.|     :..|.                   :::|..|:::
plant  1555 AASENSGVTINSFGVGQSEVCVQAVFTLLDNLGQWVDDVKQGVALSSSLQSSGGRQVAPKSKDQV 1619

  Fly  1310 TQS-------LIQALQVTDM----PEITQTILNLAEFMEHCDRDPIPIETKLLGTRAMACRAYAK 1363
            :.|       |:|...|.::    |::|                        |...:..|:|||:
plant  1620 SNSTTEQDHLLVQCKYVLELLLAIPKVT------------------------LARASFRCQAYAR 1660

  Fly  1364 ALRYKEEEFL--------LREDSQVFE-----SLILINNKLQQREAAEGLLTRYRNAANELNVQG 1415
            :|.|.|....        ..|.:.:||     ||:.|.:.|.:.:...|    :.:.:..||:|.
plant  1661 SLMYLESHVRGKSGSLNPAAEKTGIFENADVSSLMGIYSCLDEPDGLSG----FASLSKSLNLQD 1721

  Fly  1416 RWY--EKLHNWDEALEHYERNLKTDSSDLEARLGHMRCLEALGDWSELSNVT------------K 1466
            :..  :|..||.:.....|:.|:.:.:.::.....:.||  |......:.||            |
plant  1722 QLLINKKSGNWADVFTACEQALQMEPTSVQRHSDVLNCL--LNMCHHQTMVTHVDGLISRVPEYK 1784

  Fly  1467 HEWENFGTEAKSRAGPLAAVAAWGLQDWEAMREYV-------RCIPEDTQDGSYYRAVLAVHH-- 1522
            ..|...|.:           |||.|..|:.|.||:       ........:.|:.|.|..:.|
plant  1785 KTWCTQGVQ-----------AAWRLGKWDLMDEYLDGADAEGLLFSSSDSNASFDRDVAKILHAM 1838

  Fly  1523 ---DDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQYKLIPERREPLK 1584
               |.:..|:. |..::..|...|.:...:||.|||..:|.:.:|.|||:   ::.:......|:
plant  1839 MKKDQYSVAEG-IAISKQALIAPLAAAGMDSYTRAYPFVVKLHLLRELED---FQAVLNGDSYLE 1899

  Fly  1585 TMWWKRLQGGQRLVEDWRRIIQVHSLVVKPHEDI------------------HTWLKYASLCRKS 1631
            ..:....|...:.|::|...::.....:...|.:                  :.||:||.|||.:
plant  1900 KSFSTSDQVFSKAVDNWENRLRFTQSSLWTREPLLAFRRLVFGASGLGAQVGNCWLQYAKLCRLA 1964

  Fly  1632 GSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFV--STYSQ 1694
            |....:|:.   :|.......||  :...:.::.:...:..:|..:||::...:...|  ||...
plant  1965 GHYETAHRA---ILEAQASGAPN--VHMEKAKLLWITKRSDSAIIELQQSLLNMPEGVVDSTVIS 2024

  Fly  1695 ELSCL---PP---------EALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATS 1747
            .::.|   ||         ::.|::..  :|:..|..:.|.:......:.|    .|..:.:...
plant  2025 SINSLLMAPPNPEPTVRNTQSFKEKKD--VAKTLLLYSKWIHHSGQKQKKD----VLNLYTQVKE 2083

  Fly  1748 YDPNWYKAW-HLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQR---YAVPAVQ 1808
            ..| |.|.: ||..|.:...|.|:|  ..::....:|.|...|| :.|:|...:.   |....:.
plant  2084 LLP-WEKGYFHLAKYYDELYVDARK--CQQESSVFSSAGSKKGS-VSSNLSTEKAGWDYLFKGMY 2144

  Fly  1809 GFFRSISLIKGNSLQDTLRLLTLWFDYG----------------NHAEVYEALLSGMKLIEINTW 1857
            .:.:::.....|..|...||||||||:|                .|.::...:...:|.:....|
plant  2145 FYAKALHSGHKNLFQALPRLLTLWFDFGTIYKTSGSAGNKELKSTHMKIMSLMRGCLKDLPTYQW 2209

  Fly  1858 LQVIPQLIARI-----DT---HRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAF 1914
            |.|:|||::||     ||   .:.::..::||.        ||..::.:...|||...|||.||.
plant  2210 LTVLPQLVSRICHQNADTVLMVKNIITSVLHQF--------PQQGLWIMAAVSKSTVPARREAAA 2266

  Fly  1915 KILDSMRK------HSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEIL 1973
            :|:...||      ....|..|....::..|::.      :|.|...:..:     |:...|..|
plant  2267 EIIQGARKGFNQSDRGHNLFIQFASLTDHFIKLC------FHGGQPRSKVI-----NIATEFSAL 2320

  Fly  1974 EPLHAMLERGPQTLKETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLP 2038
            :.:..:                                            ||...:.|.::..||
plant  2321 KRMMPL--------------------------------------------DIIMPIQQSLTISLP 2341

  Fly  2039 QLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRGSNGKD 2103
            ...           |...:...|   |...|.:|..||.|....::::|.|||:|:.:.|::|.:
plant  2342 AFH-----------MNNNERHSA---SVFSGSDLPTISGIADEAEILSSLQRPKKIILLGNDGIE 2392

  Fly  2104 YMYLLKGHEDLRQDERVMQLFSLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTL 2168
            |.:|.|..:|||:|.|:|:..:::|.||...|::.||.|.|:.:||.||:.:.||:.||||...|
plant  2393 YPFLCKPKDDLRKDARMMEFTAMINRLLSKYPESRRRKLYIRTFAVAPLTEDCGLVEWVPHTRGL 2457

  Fly  2169 HTLIRDYR------DKKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLL-- 2225
            ..:::|..      |::|.  |.:.:.:      ||...:.::.|:.:           .|:|
plant  2458 RHILQDIYISCGKFDRQKT--NPQIKRI------YDQCAVKKEYEMLK-----------TKILPM 2503

  Fly  2226 -------WLKSPSSE--LWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFG 2281
                   |..:..||  .||..|..|..:.||.||||:|:||||||..|::.|..||..:|:||.
plant  2504 FPPVFHKWFLTTFSEPAAWFRSRVAYAHTTAVWSMVGHIVGLGDRHGENILFDSTSGDCVHVDFS 2568

  Fly  2282 DCFEVAMTREKFPEKIPFRLTRMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYD 2346
            ..|:..:..|| ||.:|||||:.:|..:.:||.||.:.|.||..:.|||.::::||::||.|::|
plant  2569 CLFDKGLQLEK-PELVPFRLTQNMIDGLGITGYEGIFMRVCEITLTVLRTHRETLMSILETFIHD 2632

  Fly  2347 PLLNWRLLDVDKKGNDAVAGAGAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNV 2411
            ||:.|                          .:...|:.||
plant  2633 PLVEW--------------------------TKSHKSSGVE------------------------ 2647

  Fly  2412 ADETNSKASQVIKRVKCKLTGTDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPFW 2471
              ..|..|.:.|..::.:|.|........|  :.|...||..|.:.|||.:.||.|.|::
plant  2648 --VQNPHAQRAISSIEARLQGVVVGVPLPV--EGQARRLIADAVSLENLGKMYIWWMPWF 2703

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
mTor	NP_001260427.1	TEL1	308..2471	CDD:227365	492/2468 (20%)
		HEAT repeat	632..658	CDD:293787	0/25 (0%)
		HEAT repeat	668..698	CDD:293787	7/34 (21%)
		HEAT repeat	706..736	CDD:293787	7/29 (24%)
		HEAT repeat	749..780	CDD:293787	7/36 (19%)
		HEAT repeat	798..823	CDD:293787	7/29 (24%)
		HEAT repeat	841..870	CDD:293787	5/28 (18%)
		HEAT repeat	880..917	CDD:293787	6/37 (16%)
		HEAT repeat	925..954	CDD:293787	2/28 (7%)
ATR	NP_001332644.1	UME	1089..1195	CDD:214825	28/162 (17%)
		TEL1	<1693..2703	CDD:227365	276/1196 (23%)
		PIKKc_ATR	2364..2639	CDD:270625	104/320 (33%)