DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Tor and TRRAP

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_001362453.1 Gene:TRRAP / 8295 HGNCID:12347 Length:3873 Species:Homo sapiens


Alignment Length:2898 Identity:536/2898 - (18%)
Similarity:963/2898 - (33%) Gaps:898/2898 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 IFTMVNATDINEKKGGALAMKCLINCEGSLTARKGISPYLNRLRDLLLINDVSVMEIAARSL-VK 119
            :|..:|:|:...::.|...|:..:  ||:......|..::..|  |:::.|.       ||| :.
Human  1390 LFKALNSTNSELQEAGEACMRKFL--EGATIEVDQIHTHMRPL--LMMLGDY-------RSLTLN 1443

  Fly   120 LANMPTS-----------KGADSFDFDIKKAFEVL-----RGER--------------------- 147
            :.|..||           |..|.....::|..||:     .|:|                     
Human  1444 VVNRLTSVTRLFPNSFNDKFCDQMMQHLRKWMEVVVITHKGGQRSDGNESISECGRCPLSPFCQF 1508

  Fly   148 -------QEYRRHSAVFILRELAIALPTYFYQHILTFFEVIFNAIFDPKPAIRESAGEALRAALI 205
                   :|.:..||:..|..|..|.|.       |..:.:...:...:.|:...||...|..||
Human  1509 EPAMEGVEEMKICSAIINLFHLIPAAPQ-------TLVKPLLEVVMKTERAMLIEAGSPFREPLI 1566

  Fly   206 VTAQRESTK---------QSSEPQWYRICYDEANGSFNADLGSSKDQKGVTRDDRIHGGLVVFNE 261
            ....|..::         ..::|||.|:        |.:.| ..||.:.:               
Human  1567 KFLTRHPSQTVELFMMEATLNDPQWSRM--------FMSFL-KHKDARPL--------------- 1607

  Fly   262 LFRCANATWERRYTSLKTLFPKTQHNKFLEASSSSSMGSQLNTLVPRLKVPFIDKLGSTQTHLGE 326
              |...|....|:.:|  |.|..........|.|:|. .:|:.....:|:..|            
Human  1608 --RDVLAANPNRFITL--LLPGGAQTAVRPGSPSTST-MRLDLQFQAIKIISI------------ 1655

  Fly   327 GEHHKGVAK-----FASQHNV---LESAYAQEILQEHYTSICDNVLEQRTSKSPYVQQALLQILP 383
                  :.|     .||||::   |...:..|..||.:..  :|:......:...:...||....
Human  1656 ------IVKNDDSWLASQHSLVSQLRRVWVSENFQERHRK--ENMAATNWKEPKLLAYCLLNYCK 1712

  Fly   384 R-----------LAAFN-----RAVFVEKYLQ--------------------------------- 399
            |           |.||.     ...|:::|::                                 
Human  1713 RNYGDIELLFQLLRAFTGRFLCNMTFLKEYMEEEIPKNYSIAQKRALFFRFVDFNDPNFGDELKA 1777

  Fly   400 TCVSHLMQ--ILRGKEKDR------------------TVAYIT-------------------IGY 425
            ..:.|::.  .|...||..                  |..:||                   :.|
Human  1778 KVLQHILNPAFLYSFEKGEGEQLLGPPNPEGDNPESITSVFITKVLDPEKQADMLDSLRIYLLQY 1842

  Fly   426 MAVAVQSA-IEVH---------LSSIMTSVKVALPSKDLTSKRKVPVDPAV-FACITLLAHAV-K 478
            ..:.|:.| ..:|         |..:||.....|.|       |..||||. ::...||||.: |
Human  1843 ATLLVEHAPHHIHDNNKNRNSKLRRLMTFAWPCLLS-------KACVDPACKYSGHLLLAHIIAK 1900

  Fly   479 SEIADDVKDILEQMFYTGLS--------------PALTVCLRELSENVPQL------KSAITEG- 522
            ..|.   |.|:.|:|::.|.              ..||..:....|:..|:      |..:.|| 
Human  1901 FAIH---KKIVLQVFHSLLKAHAMEARAIVRQAMAILTPAVPARMEDGHQMLTHWTRKIIVEEGH 1962

  Fly   523 ----LIGILSQVLMNKAAILPYTALPTIAIDGSLMQNGDGATTVLALKTLG---TFNFEEQNM-L 579
                |:.||..::.:.....|        :...|:|:     .|.|::.||   :...|::.: :
Human  1963 TVPQLVHILHLIVQHFKVYYP--------VRHHLVQH-----MVSAMQRLGFTPSVTIEQRRLAV 2014

  Fly   580 DFVQRCADYFIVHEQQEIR-------------LEAVQTCTRLLK--LAVQSSESMENSKTLSDTV 629
            |.    ::..|..|.|.|:             .|.|.:.:..:|  |:|.|::.::..:|.:..:
Human  2015 DL----SEVVIKWELQRIKDQQPDSDMDPNSSGEGVNSVSSSIKRGLSVDSAQEVKRFRTATGAI 2075

  Fly   630 SHVIER---------LLMVAI----TDMDCNVRIRILRSLDETFD-----GKLAQPESLNSLFIT 676
            |.|..|         ||...|    ||...|..||:...:::..:     |::.....:|.|...
Human  2076 SAVFGRSQSLPGADSLLAKPIDKQHTDTVVNFLIRVACQVNDNTNTAGSPGEVLSRRCVNLLKTA 2140

  Fly   677 LHDEIFEIRELAMVTIGRLSSINPAYVMPKLRTTMIELITDLKYSGMSRNKEQSAKMLDHLVIST 741
            |..:::...||.:....:|           |.|  :|....:.|..:....|..:.:|  .|:.:
Human  2141 LRPDMWPKSELKLQWFDKL-----------LMT--VEQPNQVNYGNICTGLEVLSFLL--TVLQS 2190

  Fly   742 PRLISSYMNPILKALVPKLHEPESNPGVILNVLRTIGDLAEVNGGSDEMELWADDLLSILLEMLG 806
            |.::||: .|:.:                       |..|.:..|:.::......|||.|:.:..
Human  2191 PAILSSF-KPLQR-----------------------GIAACMTCGNTKVLRAVHSLLSRLMSIFP 2231

  Fly   807 DAGSPDKRGVALWTLGQLISATGRVV----TPYHK----------------------YPVLIDIL 845
            ...|..........|..|.:|.|:|:    |.|.|                      .|..||.|
Human  2232 TEPSTSSVASKYEELECLYAAVGKVIYEGLTNYEKATNANPSQLFGTLMILKSACSNNPSYIDRL 2296

  Fly   846 IN-FLKTEQRRSIRRETIRVLGLLGAMDPYKHKMNKGLIDSQKDNVLIAYSDGKVDESQDISTAE 909
            |: |:::.|:  :.||.:......|:.:.           :...:.|:..|...|.....:.:.|
Human  2297 ISVFMRSLQK--MVREHLNPQAASGSTEA-----------TSGTSELVMLSLELVKTRLAVMSME 2348

  Fly   910 LLVNMGNALDEYYPAVAIAALMRILRDPTLSTRHTSVVQAVTFIFQSLGIKCVPYLAQVLPNLLD 974
            :..|.            |.|::..|.:.:...:   :::||..|.:.......|..|...|.|  
Human  2349 MRKNF------------IQAILTSLIEKSPDAK---ILRAVVKIVEEWVKNNSPMAANQTPTL-- 2396

  Fly   975 NVRTADNNLREFLFQQLAILVAFVKLHIISYMGDIFKLIKEFWTINTPLQNTLINLIEQIAVALG 1039
                          ::.:||       ::..|..|.|...|...:|....: |:|.:.:.....|
Human  2397 --------------REKSIL-------LVKMMTYIEKRFPEDLELNAQFLD-LVNYVYRDETLSG 2439

  Fly  1040 CEFRDYLAELIPQILRVLQ-------------HDNSKDRMVTRRLL-----QALQKFGS--TLGY 1084
            .|.   .|:|.|..|..|:             .|||..|.|..|||     |..:..|:  .:..
Human  2440 SEL---TAKLEPAFLSGLRCAQPLIRAKFFEVFDNSMKRRVYERLLYVTCSQNWEAMGNHFWIKQ 2501

  Fly  1085 YLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPELRDQAM 1149
            .:.|:|....|   |..:........|.:|.|:   ::..|...|....:|..:..||..|:.  
Human  2502 CIELLLAVCEK---STPIGTSCQGAMLPSITNV---INLADSHDRAAFAMVTHVKQEPREREN-- 2558

  Fly  1150 TTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELRPSRFK 1214
                                     ::.:..|.|.:..|:.....||      ....||......
Human  2559 -------------------------SESKEEDVEIDIELAPGDQTST------PKTKELSEKDIG 2592

  Fly  1215 NNEPFVTDRNSNNKNL----QVTTNELRTAW----QVTRRVSKDDWVEWLKRLSIGLLKESPSHA 1271
            |....:|:|  ::|.|    :|.|..|.:|:    .::..:::..||:...|| ..:|.:...||
Human  2593 NQLHMLTNR--HDKFLDTLREVKTGALLSAFVQLCHISTTLAEKTWVQLFPRL-WKILSDRQQHA 2654

  Fly  1272 LRACRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSLIQALQVTDMPEITQTILN-LAEF 1335
            |..                         |:||.|.:...|  :|.       :...:.|| ..|.
Human  2655 LAG-------------------------EISPFLCSGSHQ--VQR-------DCQPSALNCFVEA 2685

  Fly  1336 MEHCDRDPIPIE---TKLLG---------TRAMACRAYAKAL----------RYKEEEFLLREDS 1378
            |..| ..||||.   .|.||         |..:..:|:.|.|          .:.|:|.:.....
Human  2686 MSQC-VPPIPIRPCVLKYLGKTHNLWFRSTLMLEHQAFEKGLSLQIKPKQTTEFYEQESITPPQQ 2749

  Fly  1379 QVFESLILINNKLQQREAAEGL---LTRYRNAANELNVQGRWYEKLHNWDEALEHYERNLKTDSS 1440
            ::.:||..:.:.||:.:...||   ..:|...|..:.     ||:...:::|.|.||:.:  |.:
Human  2750 EILDSLAELYSLLQEEDMWAGLWQKRCKYSETATAIA-----YEQHGFFEQAQESYEKAM--DKA 2807

  Fly  1441 DLEARLGH----------------MRCLEALGDWSELSNVTKHEWENFGTEAKSRAGP-LAAVAA 1488
            ..|....:                :||.:.|..|..|:        .:| ::|....| |....|
Human  2808 KKEHERSNASPAIFPEYQLWEDHWIRCSKELNQWEALT--------EYG-QSKGHINPYLVLECA 2863

  Fly  1489 WGLQDWEAMRE-----YVRCIPEDTQDGSYYRAVLAVHHDD---FETAQRLIDETRDLLDTELTS 1545
            |.:.:|.||:|     .|.|..|.....:.||..||:.|.:   ....:||::....|...|...
Human  2864 WRVSNWTAMKEALVQVEVSCPKEMAWKVNMYRGYLAICHPEEQQLSFIERLVEMASSLAIREWRR 2928

  Fly  1546 MAGESYERAYGAMVCVQMLAELEEVIQYKL------------IPERREPLKTMWWKRLQGGQRLV 1598
            :...........:...|.:.||:|..|...            :.:.:..:|| |..||.    :|
Human  2929 LPHVVSHVHTPLLQAAQQIIELQEAAQINAGLQPTNLGRNNSLHDMKTVVKT-WRNRLP----IV 2988

  Fly  1599 ED----------WRR-----IIQVH-----------SLVVKPHEDIHTWLKYASLCRKSGSLHLS 1637
            .|          ||:     |:..:           :.::..|......::|..:.||.|.::::
Human  2989 SDDLSHWSSIFMWRQHHYQAIVTAYENSSQHDPSSNNAMLGVHASASAIIQYGKIARKQGLVNVA 3053

  Fly  1638 HKTL--VMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYE-----QLTHFVSTYSQE 1695
            ...|  :..:.|.|.::..|.:  .|....|.....:...|:..:..|     .|.:|....:.|
Human  3054 LDILSRIHTIPTVPIVDCFQKI--RQQVKCYLQLAGVMGKNECMQGLEVIESTNLKYFTKEMTAE 3116

  Fly  1696 LSCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRPDAIQGALECFEKATSYDPNWYKAWHLWA 1760
            ...|....|.|                .||.::         |.:.|..|........|||.:|.
Human  3117 FYALKGMFLAQ----------------INKSEE---------ANKAFSAAVQMHDVLVKAWAMWG 3156

  Fly  1761 -YMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSISLIKGNS-LQ 1823
             |:....|:      ::|...|.|                   |:.......|..:..|... |.
Human  3157 DYLENIFVK------ERQLHLGVS-------------------AITCYLHACRHQNESKSRKYLA 3196

  Fly  1824 DTLRLLTLWFDYGNHAEVYEALLSGMKLIEINTWLQVIPQLIARIDTHRQLVGQLIHQLLMDIGK 1888
            ..|.||:...|....|:..:....|:..|:   ||..||||:..:....   |:|:..|:..:|:
Human  3197 KVLWLLSFDDDKNTLADAVDKYCIGVPPIQ---WLAWIPQLLTCLVGSE---GKLLLNLISQVGR 3255

  Fly  1889 NHPQALVYPL-------------------------TVASKSASLA-----RRNAAF----KILDS 1919
            .:|||:.:|:                         :|.::|.|.:     |..|..    :|:..
Human  3256 VYPQAVYFPIRTLYLTLKIEQRERYKSDSGQQQPSSVGNQSHSASDPGPIRATAPMWRCSRIMHM 3320

  Fly  1920 MRKHSPTLVEQAVMCSEELIRVAILWHEQWHE--------------------------------- 1951
            .|:..|||:...    |.::...:.:.|.|||                                 
Human  3321 QRELHPTLLSSL----EGIVDQMVWFRENWHEEVLRQLQQGLAKCYSVAFEKSGAVSDAKITPHT 3381

  Fly  1952 -------------GLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTLKETSFSQAYGRELTEA 2003
                         |||..|       ||..||..... .::..|...|.::..|.:..| :.|..
Human  3382 LNFVKKLVSTFGVGLENVS-------NVSTMFSSAAS-ESLARRAQATAQDPVFQKLKG-QFTTD 3437

  Fly  2004 YEWS--QRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSY 2066
            :::|  ...|...::..|.:    :..:.:..::|||:...:|.........:.:..|:.:||.:
Human  3438 FDFSVPGSMKLHNLISKLKK----WIKILEAKTKQLPKFFLIEEKCRFLSNFSAQTAEVEIPGEF 3498

  Fly  2067 ---NPGQELIRISIIKTNLQVITS-KQRPRKLCIRGSNGKDYMYLLKGHEDL---RQDERVMQLF 2124
               .|....|:|:.....::::.. ....|:|.|||.|||.|.||:.....|   |::|||:||.
Human  3499 LMPKPTHYYIKIARFMPRVEIVQKHNTAARRLYIRGHNGKIYPYLVMNDACLTESRREERVLQLL 3563

  Fly  2125 SLVNTLLLDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYRDKKKVPLNQEHRT 2189
            .|:|..|....:|.:|:|......|:.:|....|:...|...:|..:.:....||.:    ||..
Human  3564 RLLNPCLEKRKETTKRHLFFTVPRVVAVSPQMRLVEDNPSSLSLVEIYKQRCAKKGI----EHDN 3624

  Fly  2190 MLNFAPDYDHLTLMQ------KVEVFEHALGQTQGDDLAKLLWLKS------PSSELWFERRNNY 2242
            .:  :..||.|..:|      ..:|....|.:.|.:.:.:.: ||.      |::..::..|..:
Human  3625 PI--SRYYDRLATVQARGTQASHQVLRDILKEVQSNMVPRSM-LKEWALHTFPNATDYWTFRKMF 3686

  Fly  2243 TRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKI----LHIDFGDCF-EVAMTREKFPEKIPFRLT 2302
            |..||::....::|.|...:|..|.:.:.:||:    ...|..|.. ::...|     .:|||||
Human  3687 TIQLALIGFAEFVLHLNRLNPEMLQIAQDTGKLNVAYFRFDINDATGDLDANR-----PVPFRLT 3746

  Fly  2303 RMLIKAMEVTGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGNDAVAGA 2367
            ..:.:.:...|:.|....:..:|.....:....:..:|:..:.|.::.|.     ||..:..:..
Human  3747 PNISEFLTTIGVSGPLTASMIAVARCFAQPNFKVDGILKTVLRDEIIAWH-----KKTQEDTSSP 3806

  Fly  2368 GAPGGRGGSGMQDSLSNSVEDSLPMAKSKPYDPTLQQGGLHNNVADETNSKASQVIKRVKCKLTG 2432
            .:..|:..:.....|.:.|:.::....::.::....:||                          
Human  3807 LSAAGQPENMDSQQLVSLVQKAVTAIMTRLHNLAQFEGG-------------------------- 3845

  Fly  2433 TDFQTEKSVNEQSQVELLIQQATNNENLCQCYIGWCPF 2470
                       :|:|..|:..|.:.:|||:....|.|:
Human  3846 -----------ESKVNTLVAAANSLDNLCRMDPAWHPW 3872

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 479/2592 (18%)
HEAT repeat 632..658 CDD:293787 10/38 (26%)
HEAT repeat 668..698 CDD:293787 6/29 (21%)
HEAT repeat 706..736 CDD:293787 6/29 (21%)
HEAT repeat 749..780 CDD:293787 2/30 (7%)
HEAT repeat 798..823 CDD:293787 5/24 (21%)
DUF3385 831..999 CDD:288698 31/194 (16%)
HEAT repeat 841..870 CDD:293787 8/29 (28%)
HEAT repeat 880..917 CDD:293787 5/36 (14%)
HEAT repeat 925..954 CDD:293787 5/28 (18%)
Rapamycin_bind 1937..2034 CDD:285924 20/144 (14%)
PIKKc_TOR 2075..2353 CDD:270713 68/298 (23%)
FATC 2440..2471 CDD:280430 9/31 (29%)
TRRAPNP_001362453.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 491..541
Interaction with TP53. /evidence=ECO:0000269|PubMed:12138177 2017..2395 79/444 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2030..2051 2/20 (10%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 2054..2069 4/14 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2550..2585 8/67 (12%)
TEL1 <2552..3873 CDD:227365 291/1542 (19%)
FAT 2868..3200 CDD:367004 68/388 (18%)
PIKK_TRRAP 3510..3797 CDD:270707 68/303 (22%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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