Protein Alignment Tor and zgc:158659

DIOPT Version :9

• Sequence 1: NP_001260427.1
• Gene: Tor / 47396
• FlyBaseID: FBgn0021796
• Length: 2471
• Species: Drosophila melanogaster
• Sequence 2: XP_005170630.1
• Gene: zgc:158659 / 791141
• ZFINID: ZDB-GENE-070112-492
• Length: 1070
• Species: Danio rerio
• Alignment Length: 1047
• Identity: 199/1047 - (19%)
• Similarity: 345/1047 - (32%)
• Gaps: 374/1047 - (35%)

  Fly  1529 QRLIDETRDLLDTEL-------TSMAGESYER--------AYGAMVCVQMLAELEEVIQYK---- 1574
            :...||||.|.|..|       ....|...|:        |.|..:|...|.:..||..::
Zfish    80 EEFYDETRRLCDLRLFHPILKVIEPLGNREEKILNREIGFAIGMPICEFELVKDPEVQDFRRNIL 144

  Fly  1575 -----LIPERR-------------------EPLKTMWWKRLQGGQRLVEDWRRIIQVHSLVVKP- 1614
                 .:.||.                   ..|....:.:|..|:.:|..|        ::|.|
Zfish   145 SVCREAVEEREGGGAHTQALYVYPPNVESSPDLPQHIYSKLDKGRLIVTIW--------VIVSPS 201

  Fly  1615 -----------HEDIHTWLKYASLCRKSGSLHLSHKTL------------VMLLGTDPKLNPNQP 1656
                       |:.:...|...::.:|:.|:|||.:.|            :.:.|.|.......|
Zfish   202 NSKQKYTLKIAHDSLPEQLIAEAIRKKTRSMHLSAQQLRLCVQEYQGQYILKVCGCDEYFLEKYP 266

  Fly  1657 LP-----------CNQPQVTYAYTKYMAANNQLQEAYEQL--THFVS-TYSQ---ELSCLP---- 1700
            |.           |..|.:      .:.:.:.|   |.||  :.|:: :||:   :.|..|
Zfish   267 LSQYKYIRSCITLCRLPHL------MLVSKDSL---YSQLPSSGFMAPSYSRRTPQPSPCPGGGD 322

  Fly  1701 ---PEALKQQDQRLMARCYLRMATWQN-KLQD----SIRPDAIQGALE-CFEKATSYDPNWYKAW 1756
               |.:|...:..|..|  |..||:.| .::|    .:|.....|... |....|...|.....|
Zfish   323 PGSPRSLWAFNTHLRVR--LLCATYVNVNIRDIDKIYVRTGIYHGGEPLCDNVNTQRVPCSNPRW 385

  Fly  1757 HLW-AY--------------MNFKVVQAQKSALDKQQPPGASMGMTMGS--------GLDSDLMI 1798
            :.| :|              ::...|:.:|.|.::..|      :..|:        .|.|..:.
Zfish   386 NEWLSYDIYLTDVPRSARLCLSICSVKGRKGAKEEHCP------LAWGNINLFDYKDTLVSGKVA 444

  Fly  1799 IQRYAVP-AVQGFFRSISLIKGNSLQDT--LRLLTLWF-------------DYGN---------- 1837
            :..:.|| .::.....|.:...|..::|  :.|...||             ::.|
Zfish   445 LGLWPVPHGLEDLLNPIGVSGSNPNKETPCVELEFPWFNQTVVFPDEQQIEEHANWSISRELGYS 509

  Fly  1838 ------------------HAEVYEALLSGMKLIEIN------TWL---------QVIPQLIARID 1869
                              .||....|.|...|.|::      .|.         :.:|:|:..:.
Zfish   510 YCLGLSSRLACDSSISQADAEQLRTLCSRDPLYELSEQEKDFLWRHRHYCVNIPESLPKLLLSVK 574

  Fly  1870 -THRQLVGQLIHQLLMDIGKNHPQALVYPLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAVM 1933
             ..|..|.| |:.||.|          :||.....|..|...|..          .|.:.|.|:.
Zfish   575 WNSRDEVSQ-IYCLLKD----------WPLMQPESSLELLDCNFP----------DPMVREFALR 618

  Fly  1934 C----------SEELIR-VAILWHEQ-------------------------WHEGLEEASRLYFG 1962
            |          |:.|:: |.:|.:|.                         ||...|      ..
Zfish   619 CLIQGLTDDKLSQYLLQLVQVLKYEMYLDNPLARFLIKKALTNQRIGHFFFWHLKSE------MH 677

  Fly  1963 DRNVKGMFEILEPLHAMLERGPQTLKETSFS-QAYGR--ELTEAYEWSQRYKTSAVVMDLDRAWD 2024
            ::.|...|.:|  |.|........||..:.. :|..:  .||:..:..::.:|....|..
Zfish   678 NKTVSRRFGLL--LEAFCRACGMYLKHLNRQVEAMDKLVNLTDTLKQEKKDETQKTQMKF----- 735

  Fly  2025 IYYHVFQKISRQLPQLTSLELPYVSPKLMTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQ 2089
                :.:.:||  |........:|||               .||..:|..:.:  ...::::|.:
Zfish   736 ----LVEHMSR--PDYMEALQGFVSP---------------LNPVHQLGNLRL--EECRIMSSAK 777

  Fly  2090 RPRKLCIRGSNGKDYM---------YLLKGHEDLRQDERVMQLFSLVNTLL----LDDPDTFRRN 2141
            ||  |.:...| .|.|         .:.|..:|||||...:|:..::..:.    ||
Zfish   778 RP--LWLNWEN-PDIMSELLFTNNEIIFKNGDDLRQDMLTLQIIKIMENIWQNQGLD-------- 831

  Fly  2142 LAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIR-DYRDKKKVPLNQEHRTMLNFAPDYDHLTLMQK 2205
            |.:..|..:.:....|||..|.:.   ||::: ..:...|..|.....|:.::..|      ..|
Zfish   832 LRMLPYGCLSIGDCVGLIEVVKNS---HTIMQIQCKGGLKGALQFNSNTLHHWIRD------RNK 887

  Fly  2206 VEVFEHALGQTQGDDLAKLLWLKSPSSELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDR 2270
            .|.::.|:      ||                    :|||.|...:..:|||:||||.||:|: :
Zfish   888 GEAYDRAI------DL--------------------FTRSCAGYCVATFILGIGDRHNSNIMV-K 925

  Fly  2271 MSGKILHIDFGDCFEVAMTREKF---PEKIPFRLTR--MLIKAMEVTGIEGT-----YRRTCESV 2325
            .:|::.|||||...:  ..::||   .|::||.||:  :::.:..|.....|     ::..|...
Zfish   926 ENGQLFHIDFGHFLD--HKKKKFGYKRERVPFVLTQDFLIVISKGVQECTKTKEFERFQEMCYKA 988

  Fly  2326 MLVLRRN 2332
            .|.:|::
Zfish   989 YLAIRQH 995

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	199/1047 (19%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	19/125 (15%)
		PIKKc_TOR	2075..2353	CDD:270713	65/282 (23%)
		FATC	2440..2471	CDD:280430
zgc:158659	XP_005170630.1	PI3K_p85B	32..107	CDD:280372	7/26 (27%)
		PI3K_rbd	173..292	CDD:279173	21/132 (16%)
		C2_PI3K_class_I_alpha	327..486	CDD:176043	31/166 (19%)
		PI3Ka_I	528..697	CDD:238444	38/197 (19%)
		PKc_like	696..1065	CDD:304357	81/377 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900