DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tor and pik3cb

DIOPT Version :9

Sequence 1:NP_001260427.1 Gene:Tor / 47396 FlyBaseID:FBgn0021796 Length:2471 Species:Drosophila melanogaster
Sequence 2:NP_001072928.1 Gene:pik3cb / 780390 XenbaseID:XB-GENE-482674 Length:1065 Species:Xenopus tropicalis


Alignment Length:1478 Identity:265/1478 - (17%)
Similarity:473/1478 - (32%) Gaps:528/1478 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly  1015 EFWTINTPLQNTLINLIEQIAVALGCEFRDYLAELIPQILRVLQHDNSKDRMVTRRLLQALQKFG 1079
            :.||.:|||.       ..|.|.:          |:|..:.| |.|..:|..:: .:.|.|.|..
 Frog     9 DIWTADTPLP-------PDICVDV----------LLPTGIYV-QMDVPRDASIS-HIKQLLWKHA 54

  Fly  1080 STLGYYLPLILPPIVKLFDSPYVPQQVSMVALETINNLACQLDFTDFSSRIIHPLVRVLDAEPEL 1144
            .:...:..|:               ::.....:.:|:.|...:..|.:.|:       .|..|  
 Frog    55 QSYPLFHLLL---------------EIDSYMFQCVNHNAVHEELEDETQRL-------CDVRP-- 95

  Fly  1145 RDQAMTTLRSLAKQLGKKYLVFVPMVQRTLNKHRIVDPEYEELLSKIKSCSTLADSYGAGESELR 1209
                              :|..:.:|.|:.|....:|.:...|:             |.|..|. 
 Frog    96 ------------------FLPVLKLVSRSCNPAEKLDSKIGVLI-------------GKGLQEF- 128

  Fly  1210 PSRFKNNEPFVTDRNSNNKNLQVTTNELRTAWQVTRRVSKDDWVEWLKRLSIGLLKESPSHALRA 1274
             ...|:||..    ...:|...::..::::...:|       |||||||                
 Frog   129 -DALKDNEVM----EFRSKMRSISEAKIQSLLGLT-------WVEWLKR---------------- 165

  Fly  1275 CRSLAQEYDTLLRDLFNAAFISCWTELSPDLKNELTQSL-----IQALQVTDMPEITQTILNLAE 1334
                                 :...||.|.:::.:...|     :.|:...:..::         
 Frog   166 ---------------------TFPPELEPSIQDNIQGKLYGGNIVVAIHFENCQDV--------- 200

  Fly  1335 FMEHCDRDPIPIETKLLGTRAMACRAYAKALRYKEEEFLLREDSQVFESLILINNKLQQREAAEG 1399
            |......:.:|::...|..|........:|.....|:|:|:           :|.:|:.......
 Frog   201 FSFQVSPNMVPVKVNELAIRKRLTIHGREAEEVDPEDFVLQ-----------VNGRLEFVFGDHP 254

  Fly  1400 LLTRYRNAANELNVQGRWYEKLHN--WDEALEHYERNLKTDSSDLEARLGHMRC--LEALGDWSE 1460
            |:.               ::.:.|  .::||.|               |..:.|  ::.|.| .|
 Frog   255 LIQ---------------FQYIRNCVMNKALPH---------------LTLVECCNIKKLFD-QE 288

  Fly  1461 LSNVTKHEWENFGTEAKSRAGPL-----------AAVAAWGLQD--WEAMREYVRCIPE----DT 1508
            :|.: :|     ....||...|.           |::....::|  |..::.|...:.:    :|
 Frog   289 MSEI-EH-----AVRRKSSMHPALPMPLPPKKRGASMKTLNMRDIVWNIVQPYKIILSKGSRLNT 347

  Fly  1509 QDGSYYRAVLAVHHDDFETAQRLIDETRDLLDTELTSMAGESYERAYGAMVCVQMLAELEEVIQY 1573
            :|....||.|      |...:.|...|                                      
 Frog   348 EDSVLVRAGL------FHGTELLCKPT-------------------------------------- 368

  Fly  1574 KLIPERREPLKTMWWKRLQGGQRLVEDWRRIIQ----VHSLVVKPHEDIHTWLKYASLCRKSGSL 1634
             :.||.:.....:|.:.|: .:..|.|..|:.:    :::::.||.....|  ||.:: :|||.:
 Frog   369 -MTPEVQGKNDHVWNETLE-FEINVCDLPRMARLCFAIYAVLDKPRNKNKT--KYQTI-KKSGKM 428

  Fly  1635 HLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTHFVSTYSQELSCL 1699
            |.                          .|.:..|.......||:.. :.:.|..|::..||   
 Frog   429 HF--------------------------PVAWVNTMVFDYKGQLRSG-DHVLHCWSSFPDEL--- 463

  Fly  1700 PPEALKQQDQRLMARCYLRMATWQN-KLQD-SIRPDAIQGALECFEKATSYDPNWYKAWHLWAYM 1762
              |.:......:....|....|..: |..| |..|.:.....:..|||..               
 Frog   464 --EEMLNPMGTVRTNPYTENTTTLHIKFHDYSKEPISYPPFDKILEKAAE--------------- 511

  Fly  1763 NFKVVQAQKSALDKQQPPGASMGMTMG-----------SGLDSDLMIIQRY--------AVPAVQ 1808
                :.....:|......|..:.:.:.           |..:.||:...||        ::|   
 Frog   512 ----IARNSDSLSTSGRGGKKLNIELKEIMERDPLCQLSENEKDLIWTLRYDCRENFPGSLP--- 569

  Fly  1809 GFFRSISLIKGNSLQDTLRLLTLWFDYGNHAEVYEAL--LSGMKLIEINTWLQVIPQLIAR---I 1868
               :.:..:|.|.|:|..:|..|       .:::..|  ...::|::.|     .|....|   :
 Frog   570 ---KLLLSVKWNKLEDVAQLQAL-------LQIWSKLPPRDALELLDFN-----YPDQYVREYAV 619

  Fly  1869 DTHRQLVGQLIHQLLMDIGKNHPQALVY-PLTVASKSASLARRNAAFKILDSMRKHSPTLVEQAV 1932
            :..:.:..:.:.|.|:.:    .|.|.| |....:.|..|.:|     .||:.|           
 Frog   620 NCLKPMSDEELSQYLLQL----VQVLKYEPFLDCALSRFLLQR-----ALDNRR----------- 664

  Fly  1933 MCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLE---RGPQTLKETSFSQ 1994
                  |...:.||.: .|....|..:.||               .:||   ||         |.
 Frog   665 ------IGQFLFWHLR-SEVHNPAVSVQFG---------------LLLEAYCRG---------SV 698

  Fly  1995 AYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPK--LMTC-- 2055
            |:.:.|:...|...:.:|                     ...|.:|.:::|..|..|  :.||  
 Frog   699 AHMKVLSRQVEALNKLRT---------------------LNGLIKLNAVKLSKVKNKDNMHTCLR 742

  Fly  2056 ----KDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCI--RGSNGKDYMYLLKGHEDL 2114
                |:..:.:....||...|..:.:.|  .:.:.||.:|..:..  ||........:.|..:||
 Frog   743 ENAYKEALMHIQSPLNPSITLSELVVEK--CKYMDSKMKPLWIVYNNRGFGSDSLGIIFKNGDDL 805

  Fly  2115 RQDERVMQLFSLVNTLL----LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDY 2175
            |||...:||..|::.|.    ||        |.|..|..:......|.|..|...:|:..:..|.
 Frog   806 RQDMLALQLLRLMDMLWKEAGLD--------LRIVPYGCLATGDRCGFIEVVSAAETIADIQLDS 862

  Fly  2176 RD-KKKVPLNQEHRTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSSELWFERR 2239
            .: ......|::  .:||:..:.             |:     ||||.:.:              
 Frog   863 SNLAAAAAFNKD--ALLNWIKEC-------------HS-----GDDLERAI-------------- 893

  Fly  2240 NNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKFP---EKIPFRL 2301
            ..:|.|.|...:..|:||:||||..|:|: |.:|::.|||||..  :...:.||.   |:.||.|
 Frog   894 EEFTLSCAGYCVATYVLGIGDRHNDNIMV-RKTGQLFHIDFGHI--LGNFKSKFKIKRERGPFIL 955

  Fly  2302 TRMLIKAMEV-----TGIEGTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLLDVDKKGN 2361
            |...|..::.     |...|.:|:.||...|:|||| .:|:..|.|.:..               
 Frog   956 TYDFIHVIQQGKPGNTEKFGRFRQCCEDAYLILRRN-GNLIITLFALMLT--------------- 1004

  Fly  2362 DAVAGAGAPGGRGGSGMQ---DSLS--NSVEDSLPMAKSKPYDPTLQQ 2404
                 ||.|.......:|   |||:  ...||:|...:.| :|..|::
 Frog  1005 -----AGLPELSSVKDIQYVKDSLALGKKEEDALKQFRQK-FDEALKE 1046

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
TorNP_001260427.1 TEL1 308..2471 CDD:227365 265/1478 (18%)
HEAT repeat 632..658 CDD:293787
HEAT repeat 668..698 CDD:293787
HEAT repeat 706..736 CDD:293787
HEAT repeat 749..780 CDD:293787
HEAT repeat 798..823 CDD:293787
DUF3385 831..999 CDD:288698
HEAT repeat 841..870 CDD:293787
HEAT repeat 880..917 CDD:293787
HEAT repeat 925..954 CDD:293787
Rapamycin_bind 1937..2034 CDD:285924 16/99 (16%)
PIKKc_TOR 2075..2353 CDD:270713 74/292 (25%)
FATC 2440..2471 CDD:280430
pik3cbNP_001072928.1 PI3K_p85B 33..108 CDD:308030 17/118 (14%)
PI3K_rbd 171..279 CDD:307097 20/157 (13%)
C2_PI3K_class_I_beta_delta 328..495 CDD:176075 40/247 (16%)
PI3Ka_I 533..697 CDD:238444 40/232 (17%)
PI3Kc_IA_beta 701..1062 CDD:270717 101/436 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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