DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tor and Pik3cb

DIOPT Version :9

Sequence 1:	NP_001260427.1	Gene:	Tor / 47396	FlyBaseID:	FBgn0021796	Length:	2471	Species:	Drosophila melanogaster
Sequence 2:	NP_083370.2	Gene:	Pik3cb / 74769	MGIID:	1922019	Length:	1064	Species:	Mus musculus

Alignment Length:	835	Identity:	170/835 - (20%)
Similarity:	290/835 - (34%)	Gaps:	260/835 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly  1623 KYASLCRKSGSLHLSHKTLVMLLGTDPKLNPNQPLPCNQPQVTYAYTKYMAANNQLQEAYEQLTH 1687
            ||.:: ||:|.:|.                          .|.:..|.......||:.. :.:.|
Mouse   418 KYQTI-RKAGKVHY--------------------------PVAWVNTMVFDFKGQLRSG-DVILH 454

  Fly  1688 FVSTYSQEL-SCLPPEALKQQDQRLMARCYLRMATWQNKLQDSIRP--DAIQGALECFEKATSYD 1749
            ..|::..|| ..|.|....|.:........|.:...:||.|....|  |.|      .|||....
Mouse   455 SWSSFPDELEEMLNPMGTVQTNPYAENATALHITFPENKKQPCYYPPFDKI------IEKAAELA 513

  Fly  1750 PNWYKAWHLWAYMNFKVVQAQKSALDKQQPPGASMGMTMGSGLDSDLMIIQRYAVPAVQGFFRSI 1814
            ..  .:.::.:....|.:...|..||:.         .:....::::.:|........:.|.:|:
Mouse   514 SG--DSANVSSRGGKKFLAVLKEILDRD---------PLSQLCENEMDLIWTLRQDCRENFPQSL 567

  Fly  1815 S----LIKGNSLQDTLRLLTLWFDYGNHAEVYEAL--LSGMKLIEINTWLQVIPQLIAR---IDT 1870
            .    .||.|.|:|..:|..|       .:::..|  ...::|::.|     .|....|   :..
Mouse   568 PKLLLSIKWNKLEDVAQLQAL-------LQIWPKLPPREALELLDFN-----YPDQYVREYAVGC 620

  Fly  1871 HRQLVGQLIHQLLMDIGKNHPQALVY-PLTVASKSASLARRNAAFKILDSMR------------K 1922
            .||:..:.:.|.|:.:    .|.|.| |....:.|..|..|     .||:.|            .
Mouse   621 LRQMSDEELSQYLLQL----VQVLKYEPFLDCALSRFLLER-----ALDNRRIGQFLFWHLRSEV 676

  Fly  1923 HSPTLVEQAVMCSEELIRVAILWHEQWHEGLEEASRLYFGDRNVKGMFEILEPLHAMLERGPQTL 1987
            |:|.:..|..:..|...|.::...:...:.:|..::              |:.|:::::     |
Mouse   677 HTPAVSVQFGVILEAYCRGSVGHMKVLSKQVEALNK--------------LKTLNSLIK-----L 722

  Fly  1988 KETSFSQAYGRELTEAYEWSQRYKTSAVVMDLDRAWDIYYHVFQKISRQLPQLTSLELPYVSPKL 2052
            .....|:|.|:|.                          .|...|.|.....|:.|:.|
Mouse   723 NAVKLSRAKGKEA--------------------------MHTCLKQSAYREALSDLQSP------ 755

  Fly  2053 MTCKDLELAVPGSYNPGQELIRISIIKTNLQVITSKQRPRKLCIRG-SNGKDYM-YLLKGHEDLR 2115
                         .||...|..:.:.|  .:.:.||.:|..|.... :.|:|.: .:.|..:|||
Mouse   756 -------------LNPCVILSELYVEK--CKYMDSKMKPLWLVYSSRAFGEDSVGVIFKNGDDLR 805

  Fly  2116 QDERVMQLFSLVNTLL----LDDPDTFRRNLAIQRYAVIPLSTNSGLIGWVPHCDTLHTLIRDYR 2176
            ||...:|:..|::.|.    ||        |.:..|..:.....||||..|...:|:
Mouse   806 QDMLTLQMLRLMDLLWKEAGLD--------LRMLPYGCLATGDRSGLIEVVSTSETI-------- 854

  Fly  2177 DKKKVPLNQEH---------RTMLNFAPDYDHLTLMQKVEVFEHALGQTQGDDLAKLLWLKSPSS 2232
              ..:.||..:         ..:||:..:|:                  .||||.:.:
Mouse   855 --ADIQLNSSNVAATAAFNKDALLNWLKEYN------------------SGDDLDRAI------- 892

  Fly  2233 ELWFERRNNYTRSLAVMSMVGYILGLGDRHPSNLMLDRMSGKILHIDFGDCFEVAMTREKF---P 2294
                   ..:|.|.|...:..|:||:||||..|:|: :.:|::.|||||..  :...:.||   .
Mouse   893 -------EEFTLSCAGYCVASYVLGIGDRHSDNIMV-KKTGQLFHIDFGHI--LGNFKSKFGIKR 947

  Fly  2295 EKIPFRLTRMLIKAME--VTGIE---GTYRRTCESVMLVLRRNKDSLMAVLEAFVYDPLLNWRLL 2354
            |::||.||...|..::  .||..   |.:|:.||...|:|||: .:|...|.|.:..
Mouse   948 ERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRH-GNLFITLFALMLT-------- 1003

  Fly  2355 DVDKKGNDAVAGAGAPGGRGGSGMQ---DSLS--NSVEDSLPMAKSKPYDPTLQQ 2404
                        ||.|.......:|   |||:  .|.|::|...|.| :|..|::
Mouse  1004 ------------AGLPELTSVKDIQYLKDSLALGKSEEEALKQFKQK-FDEALRE 1045

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tor	NP_001260427.1	TEL1	308..2471	CDD:227365	170/835 (20%)
		HEAT repeat	632..658	CDD:293787
		HEAT repeat	668..698	CDD:293787
		HEAT repeat	706..736	CDD:293787
		HEAT repeat	749..780	CDD:293787
		HEAT repeat	798..823	CDD:293787
		DUF3385	831..999	CDD:288698
		HEAT repeat	841..870	CDD:293787
		HEAT repeat	880..917	CDD:293787
		HEAT repeat	925..954	CDD:293787
		Rapamycin_bind	1937..2034	CDD:285924	11/96 (11%)
		PIKKc_TOR	2075..2353	CDD:270713	74/300 (25%)
		FATC	2440..2471	CDD:280430
Pik3cb	NP_083370.2	PI3K_p85B	35..112	CDD:197539
		PI3K_rbd	174..282	CDD:366310
		C2_PI3K_class_I_beta_delta	318..495	CDD:176075	20/104 (19%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	404..412
		PI3Ka_I	526..696	CDD:238444	38/199 (19%)
		PI3Kc_IA_beta	700..1061	CDD:270717	105/487 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900